ABSTRACT
A case of chronic mucocutaneous candidiasis in a Malaysian child who subsequently developed disseminated tuberculosis and toxoplasmosis is described. The phenotype of her peripheral blood mononuclear cells showed discordance for her T cell markers. The presence of a subpopulation of CD2-/CD3+ mononuclear cells leading to an immunodeficiency state is consistent with failure of activation of CD2-mediated alternative pathway resulting in immunodeficiency. Such abnormal CD2-/CD3+ subpopulations have been described in lepromatous leprosy and foetal abortuses.
Subject(s)
Antigens, Differentiation, T-Lymphocyte , CD3 Complex/analysis , Candidiasis, Chronic Mucocutaneous/complications , Candidiasis, Oral/complications , Immunologic Deficiency Syndromes/complications , Opportunistic Infections/complications , Receptors, Immunologic , T-Lymphocyte Subsets/immunology , Antigens, Differentiation, T-Lymphocyte/genetics , CD2 Antigens , Candidiasis, Chronic Mucocutaneous/immunology , Candidiasis, Oral/immunology , Disease Susceptibility/immunology , Female , Genetic Predisposition to Disease , Humans , Immunocompromised Host , Immunologic Deficiency Syndromes/genetics , Immunologic Deficiency Syndromes/immunology , Infant , Lymphocyte Activation , Opportunistic Infections/immunology , Receptors, Immunologic/genetics , Toxoplasmosis/complications , Toxoplasmosis/immunology , Tuberculosis/complications , Tuberculosis/immunologyABSTRACT
Sera from 140 lepromatous leprosy patients (test group) and 120 normal persons, who showed no clinical signs of acute or chronic toxoplasmosis (control group), were studied for the presence of Toxoplasma gondii antibody by indirect hemagglutination and indirect-immunofluorescent antibody tests. Both tests showed a high incidence of Toxoplasma antibody in the test group in comparison with the control group. IgM and IgG classes of antibody responses were observed in both the groups, which signified recent as well as past infections in them.