RESUMEN
Antileprosy activity of dialkyldithiocarbamate derivatives was studied in experiments on mice infected with M. leprae into paw pads. We found that 2-diethyldithiocarbamoyl-3-cyano-5-nitropyridine is the most promising antileprosy agent; it effectively suppresses multiplication of M. leprae and is well tolerated under conditions of chronic animal experiment.
Asunto(s)
Leprostáticos/uso terapéutico , Lepra/tratamiento farmacológico , Tiocarbamatos/uso terapéutico , Animales , Relación Dosis-Respuesta a Droga , Evaluación Preclínica de Medicamentos , Leprostáticos/sangre , Lepra/sangre , Lepra/mortalidad , Lepra/veterinaria , Masculino , Ratones , Ratones Endogámicos CBA , Viabilidad Microbiana/efectos de los fármacos , Mycobacterium leprae/efectos de los fármacos , Mycobacterium leprae/fisiología , Tiocarbamatos/sangre , Tiocarbamatos/química , Resultado del TratamientoRESUMEN
Effects of some dialkyldithiocarbamate derivatives on multiplication of M. leprae were studied in infected mice. Compounds significantly suppressing M. leprae proliferation were selected. By antibacterial activity one of these compounds was superior to dapsone, the main antileprosy drug.
Asunto(s)
Leprostáticos/farmacología , Lepra/tratamiento farmacológico , Tiocarbamatos/farmacología , Animales , Recuento de Colonia Microbiana , Dapsona/farmacología , Evaluación Preclínica de Medicamentos , Lepra/microbiología , Ratones , Ratones Endogámicos CBA , Mycobacterium leprae/efectos de los fármacosRESUMEN
We proposed a simple and economic method for determination of general toxic effects of drugs consisting in evaluation of serum morphology by polarization light microscopy.