Asunto(s)
Infecciones Bacterianas/complicaciones , Úlcera de la Córnea/etiología , Salud Global , Enfermedades Desatendidas/epidemiología , Antibacterianos/uso terapéutico , Úlcera de la Córnea/tratamiento farmacológico , Úlcera de la Córnea/prevención & control , Países en Desarrollo , Promoción de la Salud/organización & administración , Humanos , Lepra/complicaciones , Oncocercosis Ocular/complicaciones , Tracoma/complicacionesRESUMEN
AIM: To describe leprosy characteristics, ocular features, and type of organisms that produce infective corneal ulcers in leprosy patients. METHOD: The records of all leprosy patients admitted for treatment of corneal ulcers between 1992 and 1997 were reviewed. RESULTS: 63 leprosy patients, 53 males and 10 females, are described. 16 were tuberculoid and 47 lepromatous. 25 patients had completed multidrug therapy. 10 patients had face patches, eight had type I reaction, and 10 had type II reaction. 43 (68%) patients had hand deformities. In 54% of patients pain was absent as a presenting symptom. 19 patients gave a history of trauma. In 15 patients ulcers had also occurred on the other eye, five of them having occurred during the study period and the rest before 1992. Of the 68 eyes with corneal ulcers, 28 had madarosis, 34 had lagophthalmos, nine had ectropion, three had trichiasis, six had blocked nasolacrimal ducts, and 39 decreased corneal sensation. In 14 eyes, a previous lagophthalmos surgery had been done. 16 patients were blind at presentation. 32% of ulcers were located centrally. After treatment only 18% of the eyes showed visual improvement. Five types of fungus were cultured, two of them rare ocular pathogens. CONCLUSIONS: Corneal ulcers occur more in males and in the lepromatous group of patients. Decreased corneal sensation, lagophthalmos and hand deformity are closely associated. Indigenous treatment and late presentations were notable in many patients. Visual outcome is not good. There is increased risk of developing an ulcer in the other eye. Fungal corneal ulcers are not uncommon.
Asunto(s)
Úlcera de la Córnea/microbiología , Lepra Lepromatosa/complicaciones , Lepra Tuberculoide/complicaciones , Adulto , Anciano , Antiinfecciosos/uso terapéutico , Ciprofloxacina/uso terapéutico , Úlcera de la Córnea/tratamiento farmacológico , Femenino , Humanos , Cetoconazol/uso terapéutico , Masculino , Persona de Mediana Edad , Factores de Riesgo , Agudeza Visual/fisiologíaAsunto(s)
Agudeza Visual/fisiología , Antiinfecciosos/uso terapéutico , Cetoconazol/uso terapéutico , Ciprofloxacina/uso terapéutico , Factores de Riesgo , Lepra Tuberculoide/complicaciones , Lepra Lepromatosa/complicaciones , Úlcera de la Córnea/microbiología , Úlcera de la Córnea/tratamiento farmacológicoRESUMEN
Following an injury to the right eye, a corneal ulcer with hypopyon developed in a leprosy patient. Direct examination of the corneal scrapings on three occasions showed septate, branched, dematiaceous hyphal elements. When scrapings were cultured on Sabouraud's glucose and brain heart infusion agars. Bipolaris hawaiiensis was isolated repeatedly. The patient responded successfully to treatment with nystatin ointment, although the central opacity of the cornea remained and visual acuity did not improve.