Asunto(s)
Lepra Dimorfa , Síndrome de Melkersson-Rosenthal/patología , Adulto , Diagnóstico Diferencial , Femenino , Humanos , Lepra/diagnóstico , Lepra/patología , Lepra Dimorfa/diagnóstico , Lepra Dimorfa/patología , Lepra Paucibacilar/diagnóstico , Lepra Paucibacilar/patología , Labio/patología , Mycobacterium leprae/aislamiento & purificaciónRESUMEN
BACKGROUND: Macrocheilia is an inflammatory disfiguring condition responsible for the swelling of the lips. This multi-etiological entity represents a diagnostic and therapeutic challenge. Published data on macrocheilia is scarce, often limited to granulomatous cheilitis. METHODS: We conducted a retrospective study, including all patients presenting with chronic macrocheilia (CM) for nineteen years. CM was defined as a persistent enlargement of one or both lips for at least eight weeks. Both descriptive and analytical analyses were performed. RESULTS: Of the 47 patients identified, 20 (43%) had cutaneous leishmaniasis, 10 (21%) had Miescher's cheilitis, five (11%) had Melkersson-Rosenthal syndrome, five (11%) had sarcoidosis, one (2%) had lepromatous leprosy, one (2%) had systemic amyloidosis, and one (2%) had Crohn's disease. In four cases, the CM was unlabeled. Ulcerations were significantly associated with leishmaniasis (P < 0.05). Histological study showed a granulomatous infiltrate in 72% of cases. Medical treatment was adapted to the etiology of CM. Surgery was performed in two cases. Improvement of CM secondary to leishmaniasis was seen in all cases. In patients with idiopathic orofacial granulomatosis, partial improvement was noted in four cases and a total improvement in one case. Recurrences were noted in three cases after complete regression. CONCLUSIONS: Macrocheilia is a rare and disfiguring condition that requires an etiological investigation, considering that it can reveal a serious underlying systemic disease. We identified several factors that could help recognize the cause of CM, including age, history of intermittent swelling, the extent of lip enlargement, the existence of ulceration, and systemic symptoms.
Asunto(s)
Enfermedad de Crohn , Síndrome de Melkersson-Rosenthal , Enfermedad de Crohn/complicaciones , Humanos , Labio , Síndrome de Melkersson-Rosenthal/diagnóstico , Síndrome de Melkersson-Rosenthal/epidemiología , Recurrencia Local de Neoplasia , Estudios RetrospectivosAsunto(s)
Eritema/diagnóstico , Hemangioendotelioma Epitelioide/diagnóstico , Labio/patología , Neoplasias Cutáneas/diagnóstico , Diagnóstico Diferencial , Eritema/complicaciones , Femenino , Hemangioendotelioma Epitelioide/complicaciones , Humanos , Persona de Mediana Edad , Neoplasias Cutáneas/complicacionesAsunto(s)
Leishmaniasis Cutánea/diagnóstico , Leishmaniasis Visceral/diagnóstico , Labio/patología , Diagnóstico Diferencial , Humanos , Leishmaniasis Cutánea/complicaciones , Leishmaniasis Cutánea/tratamiento farmacológico , Leishmaniasis Visceral/complicaciones , Leishmaniasis Visceral/tratamiento farmacológico , Masculino , Persona de Mediana Edad , Fosforilcolina/análogos & derivados , Fosforilcolina/uso terapéuticoRESUMEN
CASE REPORT: A 5-year-old Domestic Shorthair-cross was presented with a raised, alopecic skin nodule affecting the external surface of the right upper lip with an adjacent second smaller satellite lesion. Fine needle aspiration cytology revealed numerous intracellular and extracellular negatively stained bacilli. Histopathology confirmed granulomatous inflammation with multinucleate giant cell formation and abundant intracellular acid-fast bacilli, consistent with a mycobacterial aetiology. PCR testing of the fresh tissue from the satellite lesion and subsequent sequence analysis identified Mycobacterium sp. strain Tarwin. The skin lesion was surgically excised and clarithromycin 62.5 mg twice daily was administered to the cat for 25 days. CONCLUSION: There was no recurrence of the lesion at the time of writing, 16 months after the surgery. This is the second autochthonous case of feline leprosy caused by M. sp. strain Tarwin originating in New South Wales, Australia.
Asunto(s)
Enfermedades de los Gatos/microbiología , Lepra/veterinaria , Animales , Enfermedades de los Gatos/diagnóstico , Enfermedades de los Gatos/patología , Gatos , Lepra/diagnóstico , Lepra/microbiología , Lepra/patología , Labio/patología , Mycobacterium/aislamiento & purificación , Nueva Gales del SurAsunto(s)
Anomalías Craneofaciales/diagnóstico , Párpados/anomalías , Labio/anomalías , Niño , Humanos , MasculinoAsunto(s)
Carcinoma Verrugoso/diagnóstico , Dermatosis Facial/diagnóstico , Leishmaniasis Cutánea/diagnóstico , Neoplasias Cutáneas/diagnóstico , Administración Cutánea , Anciano de 80 o más Años , Antiinfecciosos Locales/administración & dosificación , Antifúngicos/administración & dosificación , Diagnóstico Diferencial , Dermatosis Facial/tratamiento farmacológico , Femenino , Humanos , Cetoconazol/administración & dosificación , Leishmaniasis Cutánea/tratamiento farmacológico , Labio , Nariz , Povidona Yodada/administración & dosificaciónAsunto(s)
Aminoquinolinas/uso terapéutico , Antineoplásicos/uso terapéutico , Carcinoma de Células Escamosas/tratamiento farmacológico , Lupus Eritematoso Discoide/tratamiento farmacológico , Administración Cutánea , Oído , Femenino , Humanos , Imiquimod , Labio , Persona de Mediana Edad , Resultado del TratamientoRESUMEN
There is a scarcity of the histopathologically proven lesions of leprosy in the oral cavity, in the world literature. A 55-year-old man had come with a complaint of asymptomatic nodular lesions in the oral cavity. Cutaneous lesions and peripheral nerve examination were suggestive of lepromatous leprosy. Histopathologic examination of a nodule on the palate demonstrated diffuse macrophagic granulomas and acid-fast bacilli.
Asunto(s)
Lepra Lepromatosa/diagnóstico , Lepra Lepromatosa/patología , Boca/patología , Humanos , Lepra Lepromatosa/microbiología , Labio/microbiología , Labio/patología , Masculino , Persona de Mediana Edad , Boca/microbiología , Mycobacterium leprae/aislamiento & purificación , Paladar Blando/microbiología , Paladar Blando/patologíaAsunto(s)
Enfermedades de los Labios/patología , Labio/anomalías , Enfermedades Raras/patología , Adulto , Femenino , HumanosRESUMEN
In lepromatous leprosy, it may be postulated that apparently normal areas of skin are the probable sites of future extension of the pathological process and the events taking place in these site might represent the earlier stages of such an extension. Thus the present study has been done to evaluate any such changes in the apparently normal oral mucous membrane of the lepromatous leprosy patients, since oral involvement is common in these patients. Twenty two cases of lepromatous leprosy were studied histologically to see changes in apparently normal oral mucosa. Out of the 22 patients, apparently normal skin biopsies were taken from 13 patients and 5 lesional biopsies were taken from the same patients. Apparently normal oral mucosal biopsies were done for all patients. Biopsies of 22 cases of apparently normal oral mucosa did not show granulation formation of acid-fast bacilli histologically. The only change present was mild inflammation.
Asunto(s)
Lepra Lepromatosa/patología , Mucosa Bucal/patología , Mejilla/patología , Femenino , Encía/patología , Humanos , Labio/patología , Masculino , Hueso Paladar/patología , Piel/patologíaRESUMEN
Laugier-Hunziker pigmentation (LHP) is an acquired disorder of hypermelanosis characterized by mucocutaneous hyperpigmentation. LHP may resemble various disorders characterized by mucocutaneous pigmentation. A 58-year-old lady presented with progressively increasing number of variable sized, hyperpigmented macules over the lips, fingers, toes and nails. There was no family history of similar illness. Systemic examination and all relevant investigations were within normal limits. Histopathology of a skin lesion had features consistent with LHP. The diagnosis of LHP must be made only after relevant investigations to rule out any associated systemic involvement. This case further highlights that LHP is not restricted to European countries.
Asunto(s)
Hiperpigmentación/diagnóstico , Femenino , Dermatosis del Pie/etiología , Dermatosis de la Mano/patología , Humanos , Labio/patología , Persona de Mediana Edad , Enfermedades de la Uña/etiología , Enfermedades de la Lengua/etiologíaRESUMEN
Lupus vulgaris is a variant of cutaneous tuberculosis. Its more destructive and mutilating clinical forms have become rarer in consonance of a general decline of cutaneous tuberculosis. It is rarely seen now in developed countries due to stringent control measures, improved quality of living and effective therapeutic regimens. Misdiagnosis, neglect, or late diagnosis may result in severe, ulcerative and mutilating "wolf eaten" skin lesions. This paper describes four such cases of "were-wolf" cutaneous tuberculosis. Early diagnosis and treatment is important to prevent much of the disfigurement.