RESUMEN
Dapsone is an extensively Used drug for the treatment of leprosy as well as'some other clinical problems worldwide: Its use has been predicted to increase further, especially in non leprosy conditions. Treatment with Dapsone is sometimes known'to be associated with side-effects, which include gastrointestinal intolerance, haemolysis, methaemoglobinaemia, agranulocytosis, psychosis, peripheral neuritis and varied dermatological conditions, varying from simple rash to severe life threatening epidermolytic reactions and Dapsone hypersensitivity syndrome (DHS). DHS is a rare delayed hypersensitivity reaction involving multiple organs. the condition is associated with high morbidity and is potentially fatal. In this article, the focus is on etiopathogenesis, diagnosis and management of DHS. Awareness of the varied presentation/s of the condition, early recognition, withdrawal of the drug and proper management helps in rapid reduction in morbidity and preventing fatalities associated with it.
Asunto(s)
Dapsona/uso terapéutico , Leprostáticos/uso terapéutico , Lepra/tratamiento farmacológico , Agranulocitosis/etiología , Dapsona/efectos adversos , Síndrome de Hipersensibilidad a Medicamentos/etiología , Humanos , Leprostáticos/efectos adversos , Metahemoglobinemia/etiología , Enfermedades de la Piel/etiologíaRESUMEN
Dapsone is used in the treatment of autoimmune bullous diseases (AIBD), a group of disorders resulting from autoimmunity directed against basement membrane and/or intercellular adhesion molecules on cutaneous and mucosal surfaces. This review summarizes the limited published data evaluating dapsone as a therapy for AIBD.
Asunto(s)
Enfermedades Autoinmunes/tratamiento farmacológico , Dapsona/uso terapéutico , Leprostáticos/uso terapéutico , Enfermedades Cutáneas Vesiculoampollosas/tratamiento farmacológico , Agranulocitosis/etiología , Animales , Enfermedades Autoinmunes/inmunología , Dapsona/efectos adversos , Dapsona/química , Manejo de la Enfermedad , Hipersensibilidad a las Drogas/etiología , Humanos , Metahemoglobinemia/etiología , Activación Neutrófila/efectos de los fármacos , Neutrófilos/efectos de los fármacos , Neutrófilos/inmunología , Enfermedades Cutáneas Vesiculoampollosas/inmunologíaRESUMEN
Acute methemoglobinemia is an uncommon but potentially treatable disorder in witch patient can present with dramatic signs and symptoms. The early diagnostic and treatment are essentials to prevent this fatal medicine reaction.