Asunto(s)
Endometriosis/patología , Enfermedades de la Piel/patología , Ombligo/patología , Adulto , Femenino , HumanosRESUMEN
Nevoid acanthosis nigricans is a rare, benign form of acanthosis nigricans. Of the 24 cases documented in the literature, only two are exclusively localized to the umbilicus. We present four cases of nevoid acanthosis nigricans localized to the umbilicus; in patients less than 25 years of age, with no known co-morbidities, three of whom were females. Two of the cases received, with good response, treatment based on topical calcipotriol, a medication not previously reported to be used for this indication. Contrary to other types of acanthosis nigricans, the nevoid acanthosis nigricans is not associated with any syndrome, endocrinopathy, obesity, medication, or neoplasia and it can be confused with other pathologies such as epidermal nevus or dermatosis neglecta.
Asunto(s)
Acantosis Nigricans/tratamiento farmacológico , Acantosis Nigricans/patología , Ombligo/patología , Administración Tópica , Adolescente , Calcitriol/análogos & derivados , Calcitriol/uso terapéutico , Fármacos Dermatológicos/uso terapéutico , Femenino , Humanos , Masculino , Adulto JovenAsunto(s)
Queratosis/diagnóstico , Seudoxantoma Elástico/diagnóstico , Ombligo/patología , Antiinflamatorios/administración & dosificación , Clobetasol/administración & dosificación , Femenino , Antagonistas de los Receptores Histamínicos/administración & dosificación , Humanos , Queratosis/complicaciones , Queratosis/tratamiento farmacológico , Persona de Mediana Edad , Seudoxantoma Elástico/complicaciones , Seudoxantoma Elástico/tratamiento farmacológicoRESUMEN
The metastasis of a visceral malignancy to the umbilicus is known as "Sister Mary Joseph's nodule". It is a rare clinical sign indicating advanced, metastasizing intraabdominal cancer. We report a 50-year-old man who developed metastatic skin cancer in the form of semicircular indurated plaque on top of which was a firm mobile rounded nodule at the umbilical area. Histopathological examination demonstrated diastase-resistant periodic acid-Schiff and mucicarmine positive signet ring cells, suggesting gastric carcinoma. Immunohistochemical staining showed that these cells were positive for cytokeratins and epithelial membrane antigen, suggesting epithelial origin.
Asunto(s)
Neoplasias Cutáneas/diagnóstico , Neoplasias Cutáneas/secundario , Ombligo/patología , Humanos , Masculino , Persona de Mediana EdadRESUMEN
A 58-year-old, gravida 6, obese woman presented with a pruritic yellowish plaque around the umbilicus, which first appeared about 3 years ago. She also had flat yellow papules on the axilla and neck. After a burn from a heating device, a few perforating papules and a violaceous hue occurred on the plaque. Histological examination revealed pathological elastic fibers with a keratotic plug and perforation in the deep dermis, which was consistent with perforating pseudoxanthoma elasticum. This case indicates that perforating pseudoxanthoma elasticum, a variant of hereditary pseudoxanthoma elasticum may perforate due to mechanical factors.