RESUMEN
A leprosy reaction resembling Sweet syndrome was first described in 1987. This cutaneous manifestation can be classified as the type 2 reaction which arises from antigen-antibody interaction. It can occur in patients with diagnosed or undiagnosed leprosy, and men with borderline leprosy tend to exhibit this type of reaction. Triggering factors may include WHO multibacillary treatment or prescription antibiotics. Several reports of this clinical phenomenon have been published, making physicians consider it as part of this spectrum of the disease. Treatment regime can include systemic steroids and thalidomide.
Asunto(s)
Leprostáticos/uso terapéutico , Lepra/diagnóstico , Síndrome de Sweet/diagnóstico , Antibacterianos/uso terapéutico , Humanos , Lepra/complicaciones , Lepra/tratamiento farmacológico , Masculino , Síndrome de Sweet/complicaciones , Síndrome de Sweet/tratamiento farmacológico , Talidomida/uso terapéuticoAsunto(s)
Dapsona/uso terapéutico , Subunidad p52 de NF-kappa B/genética , Síndrome de Sweet/genética , Síndrome de Sweet/patología , Pueblo Asiatico/etnología , Pueblo Asiatico/genética , Encefalopatías/complicaciones , Quimiocinas/metabolismo , Niño , Dapsona/administración & dosificación , Resultado Fatal , Glucocorticoides/uso terapéutico , Humanos , Leprostáticos/uso terapéutico , Masculino , Insuficiencia Multiorgánica/complicaciones , Mutación , Prednisolona/administración & dosificación , Prednisolona/uso terapéutico , Síndrome de Sweet/complicaciones , Síndrome de Sweet/tratamiento farmacológico , Secuenciación del Exoma/métodosAsunto(s)
Síndrome de Sweet/complicaciones , Síndrome de Sweet/patología , Tiroiditis Autoinmune/complicaciones , Tiroiditis Autoinmune/diagnóstico por imagen , Corticoesteroides/uso terapéutico , Biopsia con Aguja , Femenino , Estudios de Seguimiento , Humanos , Inmunohistoquímica , Persona de Mediana Edad , Cintigrafía , Medición de Riesgo , Índice de Severidad de la Enfermedad , Síndrome de Sweet/tratamiento farmacológico , Pruebas de Función de la Tiroides , Tiroiditis Autoinmune/diagnóstico , Tiroiditis Autoinmune/tratamiento farmacológico , Resultado del TratamientoAsunto(s)
Síndromes Mielodisplásicos/complicaciones , Síndromes Paraneoplásicos/diagnóstico , Policondritis Recurrente/diagnóstico , Síndrome de Sweet/diagnóstico , Anciano , Humanos , Masculino , Síndromes Paraneoplásicos/complicaciones , Policondritis Recurrente/complicaciones , Síndrome de Sweet/complicacionesRESUMEN
Neutrophilic dermatosis of the dorsal hands, a localized form of Sweet's syndrome, was recently described, and can be associated with several diseases including infections. Chronic hepatitis C virus infection has been proposed as a possible triggering factor. The authors present a case in which the clinical and laboratory workup diagnosis only revealed positive serology for hepatitis C virus. Although a cause-effect relation could not be proved, it might be advisable to include serology for this virus in the initial evaluation of patients with neutrophilic dermatosis.
Asunto(s)
Dermatosis de la Mano/diagnóstico , Hepatitis C Crónica/diagnóstico , Síndrome de Sweet/diagnóstico , Adulto , Dermatosis de la Mano/complicaciones , Dermatosis de la Mano/tratamiento farmacológico , Hepatitis C Crónica/complicaciones , Hepatitis C Crónica/tratamiento farmacológico , Humanos , Masculino , Prednisolona/uso terapéutico , Síndrome de Sweet/complicaciones , Síndrome de Sweet/tratamiento farmacológicoRESUMEN
BACKGROUND: The clinicopathologic manifestations of Sweet's syndrome associated with malignancy have been rarely studied in a large series. METHODS: We describe the clinical features of Sweet's syndrome in 11 patients seen during the past 12 years. Histopathologic findings of these patients are discussed. The clinicopathologic manifestations of 249 cases of Sweet's syndrome reported in the literature were reviewed. RESULTS: The clinicopathologic manifestations of Sweet's syndrome associated with hematologic disorders (HSS) were more severe and characterized by bullous pyoderma with more pronounced epidermal changes and ulceration, anemia, giant platelets and abnormal platelet counts. Approximately 40% of the Sweet's syndrome reported in the literature were associated with hematologic malignancy, and the other 7% of patients had solid tumors. CONCLUSIONS: Sweet's syndrome can be classified into three types: (1) association with hematologic disorders (HSS); (2) association with solid tumors (SSS); and (3) idiopathic or associated with various other disorders (ISS).