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1.
Indian J Lepr ; 68(2): 155-9, 1996.
Artigo em Inglês | MEDLINE | ID: mdl-8835584

RESUMO

Thirty-two subjects with suspected leprosy lesions were investigated to assess various modalities of sensibility and sweat function and these were correlated with immunological and histological parameters. It was found that pain and temperature, mediated by small unmyelinated fibres were impaired in the early lesions. Impairment of sweat function was seen only when one of the modalities of sensibility was also affected. Antibodies specific to a protein (35 kDa) antigen and phenolic glycolipid 1 of Mycobacterium leprae were positive in nine and 12 cases respectively, while 15 of the 31 biopsies revealed the presence of mycobacterial antigens in these lesions. The implications of these findings are discussed.


Assuntos
Antígenos de Bactérias/análise , Hanseníase/diagnóstico , Hanseníase/imunologia , Adulto , Anticorpos Antibacterianos/sangue , Criança , Feminino , Humanos , Antígeno de Mitsuda , Hanseníase/patologia , Masculino , Mycobacterium leprae/imunologia , Limiar da Dor , Sudorese , Sensação Térmica
4.
Int J Lepr Other Mycobact Dis ; 59(1): 20-4, 1991 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-2030313

RESUMO

Serum zinc and copper levels and zinc/copper ratios were studied in 86 healthy controls, 45 cases of borderline tuberculoid (BT), 31 cases of borderline lepromatous (BL), 117 cases of lepromatous (LL) leprosy patients, 16 cases with severe erythema nodosum leprosum (ENL) reaction, and 16 cases with ENL reaction receiving oral zinc therapy. A significant reduction in serum zinc levels was noticed in all types of leprosy, the maximum decrease being seen in cases with ENL reaction. Conversely, the copper levels were significantly increased from BT to LL cases with ENL reaction in a progressive manner. A very good negative correlation (r = -0.998) was noticed between mean serum zinc and copper levels from healthy controls to active LL cases with ENL reaction. After oral zinc therapy, the serum zinc levels were significantly increased in all of the 16 LL patients with ENL reaction. In contrast, the copper levels were not decreased, indicating that oral zinc therapy can restore normal zinc levels in leprosy patients but is unable to reduce the increased copper levels.


Assuntos
Cobre/sangue , Hanseníase/sangue , Zinco/sangue , Administração Oral , Adulto , Eritema Nodoso/sangue , Eritema Nodoso/tratamento farmacológico , Humanos , Hanseníase/tratamento farmacológico , Hanseníase Dimorfa/sangue , Hanseníase Virchowiana/sangue , Hanseníase Virchowiana/tratamento farmacológico , Hanseníase Tuberculoide/sangue , Pessoa de Meia-Idade , Zinco/administração & dosagem , Zinco/uso terapêutico
6.
Indian J Lepr ; 61(2): 169-72, 1989 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-2664016

RESUMO

Subclinical infection in contacts of leprosy patients was identified by FLA-ABS test and Serum Antibody Competition Test (SACT). The risk of developing leprosy and the confidence intervals were worked out. The importance of expressing the risk ratio and confidence interval of the tests is brought out. This method is a useful adjunct to the routine statistical methods in epidemiological studies.


Assuntos
Interpretação Estatística de Dados , Hanseníase/diagnóstico , Anticorpos Monoclonais , Criança , Imunofluorescência , Humanos , Hanseníase/transmissão , Valor Preditivo dos Testes , Prognóstico , Fatores de Risco , Sensibilidade e Especificidade
7.
Indian J Lepr ; 61(1): 10-6, 1989 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-2703739

RESUMO

Investigations into the haemolytic effects of dapsone therapy were carried out in forty four leprosy patients admitted to the Sacred Heart Leprosy Centre, Kumbakonam. They received weight based dapsone dosages varying from 1.3-3.3 mg/kg body weight. Blood levels and urinary Dapsone/creatinine ratio were assessed at 1 day, 7 days and 30 days of Dapsone treatment. At the same points of time, haematological observations were also carried out. Serum bilirubin as well as blood mathaemoglobin were also examined. The findings showed a reduction in Hb levels at 30 days observation in a good proportion of cases on 100 mg. In one case (child) weighing 15 kg and receiving 50 mg dapsone increased mathaemoglobin was observed. It is suggested that dapsone dosage be regulated to body weight and preferably not to exceed 1.5 mg/kg body weight.


Assuntos
Dapsona/efeitos adversos , Hemólise/efeitos dos fármacos , Hanseníase Dimorfa/metabolismo , Hanseníase Virchowiana/metabolismo , Hanseníase Tuberculoide/metabolismo , Adolescente , Adulto , Bilirrubina/sangue , Peso Corporal , Criança , Dapsona/administração & dosagem , Dapsona/metabolismo , Esquema de Medicação , Contagem de Eritrócitos/efeitos dos fármacos , Feminino , Humanos , Hanseníase Dimorfa/tratamento farmacológico , Hanseníase Virchowiana/tratamento farmacológico , Hanseníase Tuberculoide/tratamento farmacológico , Masculino
8.
Indian J Lepr ; 60(3): 400-6, 1988 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-3058828

RESUMO

The half time of disappearance of dapsone and monoacetyl dapsone and the acetylator phenotype of the leprosy patients who harboured dapsone sensitive and dapsone resistant M. leprae was assessed in 27 subjects. Sixteen patients were rapid acetylators, five were slow and six were intermediate acetylators. The mean T 1 1/2 lives of dapsone (30.26 +/- 11.0) and monoacetyl dapsone (31.11 +/- 12.0) were also studied in the above patients. The percentage of different acetylators in both resistant and sensitive groups were similar showing no correlation between the emergence of drug resistance and the phenotype of the patient. The mean time of disappearance of DDS and MAD in the different acetylators did not show significant difference. The ratios of MAD/DDS in an individual at 3, 6 or 24 hours after the dose were similar. The mean T 1 1/2 lives of DDS and MAD in resistant and sensitive patients also showed no difference. Neither T 1 1/2 lives of DDS or MAD nor the acetylator phenotype seem to influence the emergence of dapsone resistance.


Assuntos
Dapsona/farmacologia , Hanseníase/metabolismo , Mycobacterium leprae/efeitos dos fármacos , Acetilação , Dapsona/análogos & derivados , Dapsona/sangue , Dapsona/farmacocinética , Resistência Microbiana a Medicamentos , Feminino , Meia-Vida , Humanos , Hanseníase/genética , Hanseníase/microbiologia , Masculino , Fenótipo
9.
Indian J Lepr ; 60(2): 215-24, 1988 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-3192970

RESUMO

Dapsone (DDS) in urine of 250 leprosy patients collected on surprise visits were screened by simple paper spot, tile tests and sensitive Enzyme linked immunosorbent assay (ELISA) and Haemagglutination inhibition (HI) tests. The urinary DDS concentration as well as DDS/C ratios were also studied. Simultaneously, 50 microliter of blood was collected from each of these patients and its dapsone content was estimated by HPLC. Urine samples with means of 25 to 30 micrograms/ml DDS and 55-64 micrograms/mg DDS/C ratios were found to give positive tests by any of the above screening procedures, while their mean blood DDS concentration was found to be 0.91 microgram/ml. The corresponding values for those specimens giving negative tests were 3.8 to 5.7 micrograms DDS per ml and 9 to 13 micrograms/mg DDS/C ratio. The blood DDS concentration in this group was ranging from 0.16 to 0.18 micrograms/ml. The findings are discussed in relation to their metabolic significance and their application in a leprosy control programme.


Assuntos
Dapsona/metabolismo , Hanseníase/metabolismo , Cromatografia Líquida de Alta Pressão , Dapsona/farmacocinética , Ensaio de Imunoadsorção Enzimática , Testes de Inibição da Hemaglutinação , Humanos , Hanseníase/sangue , Hanseníase/urina , Taxa de Depuração Metabólica , Cooperação do Paciente , Valor Preditivo dos Testes
11.
s.l; s.n; feb. 1988. 6 p. tab.
Não convencional em Inglês | SES-SP, HANSEN, SESSP-ILSLACERVO, SES-SP | ID: biblio-1240384

RESUMO

The influence of concurrently rifampicin and clofazimine on the metabolism of 4,4'-diaminodiphenyl sulfone (dapsone, DDS) has been studied in 30 subjects on multidrug regimens for treatment of leprosy. Plasma and urinary levels of drugs were determined on days 2,8 and 15 after administration of the drug, while cretinine levels in urine were also determined to overcome the effect of diuresis. During concurrent administration of rifampicin the plasma levels of DDS gradually fell from day 2 to day 15 of rifampicin administration and the decrease was most significant on day 15. Clofazimine did not exert any such influence on DDS metabolism. A comparison of urine and plasma levels of DDS during the course of treatment. The findings suggest that during concurrent administration of DDS and rifampicin, the intake of DDS shoud be regular and uninterrupted.


Assuntos
Humanos , Clofazimina/uso terapêutico , Dapsona/administração & dosagem , Dapsona/metabolismo , Esquema de Medicação , Hanseníase/tratamento farmacológico , Interações Medicamentosas , Quimioterapia Combinada , Rifampina/uso terapêutico
12.
Indian J Lepr ; 60(1): 47-52, 1988 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-3060546

RESUMO

A comparative study on the microbiological and spectrophotometric methods for estimation of rifampicin in urine was carried out in 15 individuals. The urinary levels of rifampicin were determined on 2nd, 8th and 15th days at 3 hour, 6 hour and 24 hour samples by the above methods after administration of 600 mg rifampicin. The results suggest that the microbiological assay is more sensitive than spectrophotometric method. The difference was highly significant in all the cases by paired t-test. Incidentally it was also noticed that urinary excretion of rifampicin was comparatively more on 15th day.


Assuntos
Técnicas Microbiológicas , Rifampina/urina , Espectrofotometria , Humanos , Rifampina/sangue , Espectrofotometria/métodos
13.
Indian J Lepr ; 59(4): 442-9, 1987.
Artigo em Inglês | MEDLINE | ID: mdl-3451926

RESUMO

As part of the studies on nerve damage and its consequences in leprosy, the status of sweat gland function in the anaesthetic sole of the feet of leprosy patients was investigated qualitatively and semi-quantitatively, before and after surgical decompression of the posterior tibial neurovascular bundle. Sweat prints of the feet of the patients were obtained pre-operatively and postoperatively on Whatman's No. 1 filter paper. The paper was treated with one percent Ninhydrin and the intensities of the Ninhydrin positive areas were quantitated. Forty one feet of thirty six patients have been studied in this manner. Sweat print analysis of twenty normal people have also been done, and included for comparison. This operative procedure has been found to effect an improvement in the sweat gland function in the feet of more than fifty percent of leprosy patients studied so far.


Assuntos
Pé/fisiopatologia , Hanseníase/fisiopatologia , Síndromes de Compressão Nervosa/cirurgia , Sudorese , Nervo Tibial/fisiopatologia , Humanos , Hanseníase/complicações , Síndromes de Compressão Nervosa/etiologia , Síndromes de Compressão Nervosa/fisiopatologia , Período Pós-Operatório , Nervo Tibial/cirurgia
15.
Indian J Lepr ; 58(4): 555-9, 1986.
Artigo em Inglês | MEDLINE | ID: mdl-3572097

RESUMO

The field workers of two MDT districts (Srikakulam in Andhra Pradesh and Ganjam in Orissa) were trained for implementation of 'Paper Spot Test together with Pill/Capsule count methods' of monitoring the treatment compliance of leprosy out-patients receiving MDT. All the workers recognized the importance of implementing these methods and found them operationally feasible, in field. Of the 672 Paucibacillary and 749 multibacillary cases monitored for drug compliance, 85-88% cases showed regular compliance (more than 75% drug intake) to dapsone. The compliance to Clofazimine among Multibacillary cases was better (94% regular) than dapsone compliance. Both these monitoring methods are advocated to be used on larger scale under our National Leprosy Eradication Programme.


Assuntos
Hansenostáticos/uso terapêutico , Hanseníase/tratamento farmacológico , Cooperação do Paciente , Clofazimina/uso terapêutico , Dapsona/uso terapêutico , Quimioterapia Combinada , Humanos
16.
Indian J Lepr ; 58(3): 401-6, 1986.
Artigo em Inglês | MEDLINE | ID: mdl-3794408

RESUMO

The metabolism of the repository drug acedapsone (DADDS,4,4'-diacetyldiaminodiphenyl sulfone) was studied in 15 individuals receiving 225 mg of DADDS, intramuscularly for a period of 75 days. Plasma levels of DDS were determined on the 2nd, 7th, 15th, 30th, 60th and 75th day after administration of the drug by spectrophoto-fluorometric technique. The mean peak levels of DDS (85.36 ng/ml) were noticed on 7th day followed by a gradual decrease in DDS concentration. The mean half-life level (44.53 ng/ml) of DDS were observed around the 15th day. The mean DDS level for the entire period of observation after one dose was 41.95 ng/ml. On the 75th day, the DDS level reached the minimum value of 14.76 ng/ml which was still about 5 times more than the minimal inhibitory concentration (MIC) level of DDS against M. leprae (3 ng/ml). The results are discussed.


Assuntos
Acedapsona/uso terapêutico , Dapsona/análogos & derivados , Dapsona/sangue , Hanseníase/sangue , Acedapsona/sangue , Acedapsona/metabolismo , Adulto , Animais , Dapsona/metabolismo , Meia-Vida , Humanos , Hanseníase/tratamento farmacológico , Camundongos , Fatores de Tempo
17.
Indian J Lepr ; 58(2): 191-5, 1986.
Artigo em Inglês | MEDLINE | ID: mdl-3805790

RESUMO

Two hundred and five sera from lepromatous leprosy patients were tested for the presence of thyroglobulin autoantibodies using tanned red cell haemagglutination technique. Six out of 182 sera from LL patients and 5 out of 23 sera from LL patients with ENL gave a positive reaction for thyroglobulin autoantibodies.


Assuntos
Autoanticorpos/análise , Hanseníase/diagnóstico , Tireoglobulina/imunologia , Eritema Nodoso/diagnóstico , Testes de Hemaglutinação , Humanos
18.
Indian J Lepr ; 57(3): 601-6, 1985.
Artigo em Inglês | MEDLINE | ID: mdl-3831099

RESUMO

A comparative study of the HI test and paper spot test for screening dapsone in urine was carried out in 692 specimens of urine, 149 from the field and 502 from patients attending the C.L.T. and R.I. clinic or admitted in the wards and 41 control urines. A very good correlation was noticed between the 2 tests in relation to positivity or negativity as well as DDS concentration. Fifty one urine specimens showed a specific agglutination, 41 of them were considered HI positive and 10 of them HI negative based on DDS concentration. The results are discussed.


Assuntos
Colorimetria , Dapsona/urina , Testes de Inibição da Hemaglutinação , Creatinina/urina , Humanos
19.
In. Dharmendra, M. Leprosy. Bombay, Samant and Company, 1985. p.886-9.
Monografia em Inglês | LILACS-Express | SES-SP, HANSEN, SESSP-ILSLACERVO, SES-SP | ID: biblio-1244068
20.
Indian J Lepr ; 57(2): 323-8, 1985.
Artigo em Inglês | MEDLINE | ID: mdl-3908578

RESUMO

Mouse foot-pad experiments were carried out to study the effects of DFS and related compounds on the multiplication of M. leprae. Of the 25 cases clinically suspected Dapsone resistance, 8 were found resistant and 14 sensitive to Dapsone by mouse foot-pad experiments. Six were resistant to DFS and 16 were sensitive. Desoxy fructo 5-hydroxy tryptophane as well as Nutrition Antileprosy (NAL) diet were also found effective in suppressing the growth of M. leprae in mouse foot-pad. Of the two liposoluble derivatives of DFS tested (DFS LS-I and DFS LS-II), DFS LS-II was found more effective in suppressing the growth of M. leprae in foot-pads of mice.


Assuntos
Mycobacterium leprae/efeitos dos fármacos , Serotonina/análogos & derivados , Animais , Dapsona/farmacologia , Dapsona/uso terapêutico , Resistência Microbiana a Medicamentos , Pé/microbiologia , Humanos , Hansenostáticos/farmacologia , Hanseníase/dietoterapia , Hanseníase/tratamento farmacológico , Camundongos , Mycobacterium leprae/fisiologia , Serotonina/administração & dosagem , Serotonina/farmacologia
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