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In. Dharmendra, M. Leprosy. Bombay, Samant and Company, 1985. p.1071-94, tab.
Monografia em Inglês | LILACS-Express | LILACS, SES-SP, HANSEN, SESSP-ILSLACERVO, SES-SP | ID: biblio-1244084
Int J Lepr Other Mycobact Dis ; 49(4): 427-30, 1981 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-7042607


A survey of the prevalence of primary dapsone-resistant leprosy in Cebu, Philippines, has yielded an estimate of 3.6 per 100. Fifty-three of 55 patients proved to have M. leprae fully susceptible to dapsone. The organisms of two patients multiplied in mice administered the minimal effective dose of dapsone; and those of one of these patients also multiplied in mice administered dapsone in a 10-fold larger dose.

Dapsona/uso terapêutico , Hanseníase/tratamento farmacológico , Animais , Dapsona/farmacologia , Resistência Microbiana a Medicamentos , Humanos , Hanseníase/microbiologia , Camundongos , Camundongos Endogâmicos CBA , Mycobacterium leprae/efeitos dos fármacos , Filipinas
Int J Lepr Other Mycobact Dis ; 49(1): 21-6, 1981 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-7195880


A test is described that utilized a laser nephelometric measure of the interaction between human serum and a leprosy biopsy suspension to demonstrate household contact with a leprosy index case. None of the test sera was from persons with clinical evidence of the disease. There was a 5:1 ratio of higher level reactors in sera from household contacts vs high level reactors in sera from persons in the surrounding community. This did not appear to be a result of age, sex, family relationship to the index case, or clinical character of the index case. Some index cases had high level serum reactors among their contacts; others did not. This phenomenon was not a function of the clinical classification of the index case. The reason is unknown. This test should provide another practical means to study leprosy.

Hanseníase/diagnóstico , Adolescente , Adulto , Criança , Estudos de Avaliação como Assunto , Feminino , Humanos , Hanseníase/sangue , Hanseníase/transmissão , Masculino , Pessoa de Meia-Idade
Int J Lepr Other Mycobact Dis ; 46(1): 25-9, 1978.
Artigo em Inglês | MEDLINE | ID: mdl-565753


A life-table approach was employed to estimate expectation of survival of the non-leprous members of a population in which leprosy is endemic. The observed survival of members who developed lepromatous leprosy at different ages was compared with that expected after having attained the age at which onset occurred. Those whose onset occurred at later, as opposed to earlier, ages more frequently lived their expected remaining years of life. Survival was not decreased in those whose onset occurred after age 20. It is hypothesized that those whose onset occurs after maturity are more resistant to complications arising from infection with M. leprae which can lead prematurely to death.

Fatores Etários , Hanseníase/mortalidade , Adolescente , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade
Bull World Health Organ ; 43(4): 559-69, 1970.
Artigo em Inglês | MEDLINE | ID: mdl-5313068


From changes in the morphology and viability of Mycobacterium leprae in infected mice, some authors have concluded that the majority of smear-positive human lepromatous patients become non-infectious within 3-4 months of the beginning of regular treatment with sulfones, even at dosages equivalent to only one-hundredth of the conventional daily dose-namely, 1 mg daily. These very low dosages have, however, not been advocated because of the risk that resistant strains of Myco. leprae might develop. The laboratory findings have already been applied to human leprosy by some leprologists; if they were more widely adopted, leprosy programmes could be seriously affected and the consequences could be serious in endemic areas. Contrary to the results of laboratory tests, the shortcomings of clinical sulfone therapy are evident all over the world from the long times required for lepromatous cases to become bacteriologically negative, from the high proportion of relapses and from chemoprophylaxis trials in child contacts. Final proof of the relationship between the morphological index, i.e., the proportion of solidly staining bacilli present, and contagiousness can come only from prolonged and well-planned epidemiological studies. It appears that leprosy may develop in appreciable numbers of child contacts exposed to index cases already bacteriologically negative, with or without prophylactic dapsone treatment.The results of controlled BCG trials now in progress are not consistent although laboratory trials in mice have indicated that BCG vaccination confers a high degree of protection. However, the results that have been obtained in the mouse, an unnatural host, may not be obtainable in man.It is considered premature to apply laboratory findings to human leprosy before clinical and epidemiological studies have been made in man.

Animais , Vacina BCG , Dapsona/uso terapêutico
s.l; s.n; 1970. 11 p. tab.
Não convencional em Inglês | SES-SP, HANSEN, SESSP-ILSLACERVO, SES-SP | ID: biblio-1232439

Int. j. lepr ; 30(1): 27-47, Jan.-Mar. 1962. tab, graf
Artigo em Inglês | SES-SP, HANSEN, SESSP-ILSLACERVO, SES-SP | ID: biblio-1228013


Comparative tests of Wade's "purified acillus suspension" and the standard lepromin prepared from the same pool of leproma have been made in the Philippiones, Netherlands New Guinea, East Africa and South Africa. Consistently in the comparisons the standard lepromin gave more positive Mitsuda reactions, or more strong reactions, than the suspension; and in the healthy children tested the PBS sometimes gave negative results when the reactions to lepromin were positive. For this reason alone it would not be satisfactory for use in field work in which children are involved. Lepromin gave more early reactions than the suspension in the cases for which that effect was reported (Philippines), suggesting that in the preparation of the latter the immediately-available antigenic elements had partly been eliminated. The suspension on the whole caused somewhat less ulceration of the reaction lesions, which is a point in its favor. However, contrary findings were not infrequent, so use of the product could not be advocated strongly on that ground. The results in tuberculoid cases permit comparison of the reactivities of the four different regional groups, whether considering average sizes of the reaction lesions or the percentage of the stronger reactions. Despite the high percentages of positive reactors in the Philippine subjects, the New Guinea people proved to be distinctly more so, and the East African cases the most reactive of all. The South African cases were much less reactive in comparison. The question of why people living in different environments differ materially in reactivity remains an intriguing problem.

Antígeno de Mitsuda/classificação , Hanseníase , Hanseníase/classificação
In. International Congress of Leprology, 7; Congresso Internacional de Leprologia, 7. International Congress of Leprology, 7/Congresso Internacional de Leprologia, 7/Transactions. Tokyo, Tofu Kyokai, 1959. p.193-206, tab, graf.
Não convencional em Inglês | SES-SP, HANSEN, SESSP-ILSLACERVO, SES-SP | ID: biblio-1245887

In. International Congress of Leprology, 7; Congresso Internacional de Leprologia, 7. International Congress of Leprology, 7/Congresso Internacional de Leprologia, 7/Transactions. Tokyo, Tofu Kyokai, 1959. p.206-15.
Não convencional em Inglês | SES-SP, HANSEN, SESSP-ILSLACERVO, SES-SP | ID: biblio-1245888

Int. j. lepr ; 26(4): 328-345, Oct.-Dec. 1958. tab, graf
Artigo em Inglês | SES-SP, HANSEN, SESSP-ILSLACERVO, SES-SP | ID: biblio-1227872


To ascertain whether or not high dilutions of lepromin would be practical for the field testing of normal populations, two series of tests were made with healthy schoolchildren aged 6-9 years. The first series comprised five groups averaging 116 children each, all of Opon poblacion (town), the second one five groups averaging 92 each, all of outlying barrios (rural villages). None had been lepromin tested before or BCG vaccinated, and none was given more than one injection of lepromin. In the first series two lepromins made by different methods (M, by Mabalay, and W, By Wade) were compared with each other and with the Dharmendra antigen, and two dilutions (1/10 and 1/20) of the stock W lepromin were also used. The tests in the second series were with five concentrations of the W lepromin: 1/1 (i.e., undiluted), 1/10, 1/20, 1/40 and 1/80. With respect to the late reaction, the two lepromins in Series 1 gave the same results, 75 per cent positives. The M stock, however, elicited fewer early reactions than the W stock, suggesting that boiling may be less effective than autoclaving in freeing the soluble antigenic elements involved in that reaction. In series 2 the full-dose W lepromin gave rise to more positive reactions of both kinds than it had in Series 1, and the dilutions gave increasingly large differences with respect to the late reaction. The Dharmendra antigen proved ineffective in eliciting either type of response in these very young and immature subjects, this result with the late reaction probably due to the extraction of the lipids during manufacture....

Criança , Antígeno de Mitsuda/administração & dosagem , Antígeno de Mitsuda/efeitos adversos , Hanseníase/classificação , Hanseníase/diagnóstico
Int. j. lepr ; 26(4): 396-406, Oct.-Dec. 1958.
Artigo em Inglês | SES-SP, HANSEN, SESSP-ILSLACERVO, SES-SP | ID: biblio-1227882
Int. j. lepr ; 25(2): 104-109, Apr.-Jun. 1957. tab
Artigo em Inglês | SES-SP, HANSEN, SESSP-ILSLACERVO, SES-SP | ID: biblio-1227754


1- Approximately 40 per cent of the sera from healthy children residing in an area endemic for leprosy gave positive results when tested for antituberculopolysaccharides. The titers approached those seen in normal individuals generally. 2- There was no apparent correlation between lepromin reactivity of the donors and the reactivity of their sera. 3- Differences in specificities of the test antigens is present by way of explanation.

Antígeno de Mitsuda , Hanseníase , Hanseníase/classificação , Hanseníase/diagnóstico