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1.
Acta Leprol ; 9(2): 83-8, 1994.
Artigo em Inglês | MEDLINE | ID: mdl-7863756

RESUMO

Histopathological slides from skin biopsies of fifty-seven self-reporting patients diagnosed as indeterminate leprosy by the Leprosy Control Programme in São Paulo, were sent to three independent histopathologists. Agreement between the reports were based on the following diagnosis: "indeterminate leprosy", "suggestive leprosy" or "no leprosy". A great variation was observed in the interpretation of the histopathological examination. The three pathologists reported "indeterminate leprosy" respectively in 7.0%, 54.4% and 84.2%, of the cases studied. A kappa index of agreement between any two pathologists ranged from 0.08 to 0.32, showing poor agreement between observers. Agreement improved by pooling together the reports "suggestive leprosy" and "indeterminate leprosy". The three pathologists agreed in the results of 24 biopsies of the 27 classified as leprosy by any one of the three observers. Eight cases were considered as "no leprosy" by all pathologists. Higher agreement indices were obtained for positive and negative proportionate concordance between any two examiners. The implications of the variation in the diagnosis of indeterminate leprosy and early leprosy are discussed in the context of public health and case-management.


Assuntos
Hanseníase/patologia , Brasil , Humanos , Hanseníase/classificação , Variações Dependentes do Observador , Patologia/estatística & dados numéricos
2.
In. Hastings, Robert C. Leprosy. London, Churchill, 2 ed; 1994. p.177-92, ilus.
Monografia em Inglês | LILACS-Express | SES-SP, HANSEN, SESSP-ILSLACERVO, SES-SP | ID: biblio-1244863
3.
Lepr Rev ; 63(1): 21-7, 1992 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-1569812

RESUMO

With the introduction of reproducible serological tests it was hoped that relapses in leprosy patients, after discontinuing treatment, could be detected before damaging reactions occurred and before the patients became infectious. The possible value of an ELISA using a semisynthetic analogue of phenolic glycolipid-I to detect antibodies to this antigen in order to predict a relapse in multibacillary patients was investigated. In contrast to that reported for paucibacillary patients, this test was useful to detect early relapses in multibacillary patients. In 3 out of 4 multibacillary patients who relapsed, the ELISA-values were increased. The decreased ELISA-values in the one relapsed patient could be attributed to the corticosteroid therapy. In the multibacillary patients who did not relapse after RFT, the ELISA-values were consistently low or decreased. In only one patient did the ELISA-values increase following his release from treatment and this patient was clinically suspected of developing a relapse.


Assuntos
Anticorpos Antibacterianos/análise , Glicolipídeos/imunologia , Hanseníase/tratamento farmacológico , Adulto , Idoso , Antígenos de Bactérias/imunologia , Ensaio de Imunoadsorção Enzimática , Seguimentos , Humanos , Hanseníase/imunologia , Hanseníase/patologia , Masculino , Pessoa de Meia-Idade , Mycobacterium leprae/imunologia
4.
In. Leiker, D. L; McDougall, A. C. Technical guide for smear examination for leprosy. Würzburg, TALMILEP, 2 ed. rev; 1987. p.13-22, ilus, tab.
Monografia em Inglês | LILACS, SES-SP, HANSEN, SESSP-ILSLACERVO, SES-SP | ID: biblio-1243723
5.
In. Leiker, D. L; McDougall, A. C. Technical guide for smear examination for leprosy. Würzburg, TALMILEP, 2 ed. rev; 1987. p.21-2.
Monografia em Inglês | SES-SP, HANSEN, SESSP-ILSLACERVO, SES-SP | ID: biblio-1243724
6.
In. Leiker, D. L; McDougall, A. C. Technical guide for smear examination for leprosy. Würzburg, TALMILEP, 2 ed. rev; 1987. p.23-8, tab.
Monografia em Inglês | SES-SP, HANSEN, SESSP-ILSLACERVO, SES-SP | ID: biblio-1243725
7.
In. Leiker, D. L; McDougall, A. C; Souza, Ana Tereza Orsi; Monzon, Martina Feced; Talhari, Sinésio. Guia técnico: baciloscopia da hanseníase. Wurzburg, TALMILEP, 2 ed; 1987. p.4-10, tab.
Monografia em Português | LILACS-Express | SES-SP, HANSEN, SESSP-ILSLACERVO, SES-SP | ID: biblio-1243734
8.
In. Leiker, D. L; McDougall, A. C; Souza, Ana Tereza Orsi; Monzon, Martina Feced; Talhari, Sinésio. Guia técnico: baciloscopia da hanseníase. Wurzburg, TALMILEP, 2 ed; 1987. p.21-2.
Monografia em Português | LILACS-Express | SES-SP, HANSEN, SESSP-ILSLACERVO, SES-SP | ID: biblio-1243736
9.
In. Leiker, D. L; McDougall, A. C; Souza, Ana Tereza Orsi; Monzon, Martina Feced; Talhari, Sinésio. Guia técnico: baciloscopia da hanseníase. Wurzburg, TALMILEP, 2 ed; 1987. p.23-7, tab.
Monografia em Português | LILACS-Express | SES-SP, HANSEN, SESSP-ILSLACERVO, SES-SP | ID: biblio-1243737
10.
Würzburg; TALMILEP; 2 ed. rev; 1987. 32 p. ilus, tab, ^e21cm.
Monografia em Inglês | SES-SP, HANSEN, SESSP-ILSLACERVO, SES-SP | ID: biblio-1230542
11.
Wurzburg; TALMILEP; 2 ed; 1987. 32 p. ilus, tab, ^e21cm.
Monografia em Português | LILACS-Express | SES-SP, HANSEN, SESSP-ILSLACERVO, SES-SP | ID: biblio-1230544
14.
16.
In. Leiker, D. L; McDougall, A. C; Le Correler, Y. Les exames microscopiques dans la lèpre: guide technique. Paris, Association Française Raoul Follereau, 1986. p.11-21, ilus, tab.
Monografia em Francês | SES-SP, HANSEN, SESSP-ILSLACERVO, SES-SP | ID: biblio-1243720
17.
In. Leiker, D. L; McDougall, A. C; Le Correler, Y. Les exames microscopiques dans la lèpre: guide technique. Paris, Association Française Raoul Follereau, 1986. p.22-3, ilus.
Monografia em Francês | SES-SP, HANSEN, SESSP-ILSLACERVO, SES-SP | ID: biblio-1243721
18.
In. Leiker, D. L; McDougall, A. C; Le Correler, Y. Les exames microscopiques dans la lèpre: guide technique. Paris, Association Française Raoul Follereau, 1986. p.24-6, tab.
Monografia em Francês | SES-SP, HANSEN, SESSP-ILSLACERVO, SES-SP | ID: biblio-1243722
19.
Paris; Association Française Raoul Follereau; 1986. 35 p. ilus, tab, ^e21cm.
Monografia em Francês | SES-SP, HANSEN, SESSP-ILSLACERVO, SES-SP | ID: biblio-1230541
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