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1.
Eye (Lond) ; 25(6): 740-5, 2011 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-21423140

RESUMO

OBJECTIVE: The objective of this study was to determine the prevalence of ocular complications and blindness among leprosy patients presenting in the United Kingdom. METHODS: Observational prospective study. RESULTS: A total of 126 consecutive leprosy patients attending their ophthalmic visit were examined, out of which 18 patients were blind in one eye (14.3%) and five patients were blind in both the eyes (4.0%). Visual acuity of ≥ 6/18 was present in 96 patients (76.2%). A total of 65 patients (51.6%) had an ocular complication and 28 patients (22.2%) had a sight-threatening leprosy complication (lagophthalmos, severe corneal, or iris disease). The most common ocular complications were impaired lid closure (24 patients, 19%), impaired corneal sensation (20 patients, 15.9%), cataract (20 patients, 15.9%), mild corneal opacity (17 patients, 13.5%), and iris atrophy (17 patients, 13.5%). Impaired corneal sensation was associated with vision <6/18 (P<0.001, OR 13.5, 95% CI 5.14-35.44) and vision <3/60 (P=0.01 OR 6.42, 95% CI 2.15-19.15). Impaired lid closure was significantly associated with increasing age (P=0.029, OR 1.039, 95% CI 1.0-1.08) and vision <3/60 (P=0.03, OR 6.06, 95% CI 1.81-20.24). CONCLUSION: There is a significant rate of ocular complications and blindness seen in leprosy patients in the United Kingdom, and over one in five had a potentially sight-threatening ocular complication. Health professionals and all leprosy patients, including those cured of the disease, need to be aware that new eye symptoms and signs require prompt ophthalmology review to prevent avoidable blindness, due to the life-long risk of sight-threatening ocular complications.


Assuntos
Oftalmopatias/epidemiologia , Hanseníase/complicações , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Criança , Pré-Escolar , Oftalmopatias/etiologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Prevalência , Estudos Prospectivos , Reino Unido/epidemiologia , Transtornos da Visão/epidemiologia , Adulto Jovem
3.
Artigo em Inglês | MEDLINE | ID: mdl-17657006

RESUMO

A lady presented with multiple, tender discharging noduloulcerative lesions on the abdomen, following laparoscopic cholecystectomy. Histopathological features were suggestive of panniculitis. Screening of the serum for alpha-1 antitrypsin levels revealed a partial deficiency.

4.
Artigo em Inglês | MEDLINE | ID: mdl-17657007

RESUMO

Rheumatoid nodules occur usually in advanced seropositive rheumatoid arthritis, signifying poor prognosis. However rarely rheumatoid nodules can be encountered in patients with no antecedent evidence of arthritis. Herein a case of an arthritic benign rheumatoid nodules is described.

5.
Acta Cytol ; 43(5): 771-6, 1999.
Artigo em Inglês | MEDLINE | ID: mdl-10518129

RESUMO

OBJECTIVE: To define diagnostic cytomorphologic features of reactions in leprosy. STUDY DESIGN: Part-retrospective, part-prospective, single-blind, controlled study of the applicability of fine needle aspiration cytology in the diagnosis of reactions in leprosy. Cytomorphologic features were compared in 42 clinically diagnosed patients with reactions in leprosy with those in a control group of patients with nonreactional leprosy. The study groups included type 1 and type 2 reactions in 35 and 9 patients, respectively. May-Grünwald-Giemsa and Ziehl-Neelsen staining methods were employed. RESULTS: Statistically significant (P < .01) cytomorphologic features of type 1 reaction were the presence of fragments of collagen and elastin; giant cells; giant cells exhibiting elastin phagocytosis; loose, epithelioid cell granulomas; and fibroblasts. Type 2 reaction was characterized in aspirates by the presence of an abundance of neutrophils in a background of lepromatous leprosy (P < .01). CONCLUSION: Criteria that are used in histopathology for the diagnosis of leprosy reactions can be applied satisfactorily to cytologic smears. A good correlation between clinical diagnosis and cytomorphology can be achieved. Multiple-site aspirates from the skin, nerve and lymph nodes are helpful in substantiating the diagnosis.


Assuntos
Hanseníase/patologia , Pele/patologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Biópsia por Agulha , Criança , Colágeno/análise , Elastina/análise , Feminino , Células Gigantes/patologia , Humanos , Hanseníase Dimorfa/patologia , Hanseníase Tuberculoide/patologia , Masculino , Pessoa de Meia-Idade , Fagocitose , Estudos Prospectivos , Valores de Referência , Estudos Retrospectivos , Pele/citologia
7.
Artigo em Inglês | MEDLINE | ID: mdl-20921792

RESUMO

A total of 320 patients of more than 60 years of age were studied for dermatological changes with aging. The male female ratio of patients was 3:1. Majority of cases (60.6%) were between 60-65 years of age. Pruritus was present in 37.5% cases, wrinkles in 82.1%, senile lentigenes in 57.8%, seborrhoeic keratosis in 48.8%, cherry angioma in 48.1%, idiopathic guttate hypomelanosis in 43%, skin tags in 37%, xerosis in 28%, comedones in 19%, infection and infestation in 40%, eczematous disorders in 36.9%, papulosquamous disorders in 10%, metabolic disorders in 16%, pigmentary disorders in 8.7%, keratinisation disorders in 4.1%, vesiculobullous disorders in 2.8% and associated systemic disorders in 49.7% cases.

8.
Med J Armed Forces India ; 54(2): 173, 1998 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-28775464
9.
Artigo em Inglês | MEDLINE | ID: mdl-20944265

RESUMO

Pyoderma gangrenosum (PG) has previously been reported in very few patients with HIV infection. We describe here a 30-year-old housewife with HIV infection having multiple ulcerations over lower limbs characteristic of PG.

11.
Indian J Pathol Microbiol ; 39(1): 5-12, 1996 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-8755125

RESUMO

Cell mediated immunity was studied in 50 patients of leprosy and 15 control volunteers, by estimation of peripheral blood lymphocytes (PBL), total rosette forming cells (TRFC) and active rosette forming cell (ARFC) counts in vitro. PBL, TRFC and ARFC counts were slightly but not significantly increased in patients of tuberculoid leprosy (TT) and muculoanaesthetic variant of tuberculoid leprosy as compared to control group. However, gradual decrease in T-cell subsets, occurred in borderline tuberculoid leprosy (BT) as compared to tuberculoid type (TT)-(p < 0.05). Significant decrease in lymphocytes and T-cell subsets was observed in midborderline leprosy (BB), (p < 0.01):borderline lepromatous leprosy (BL), (p < 0.001) and lepromatous subpolar and polar types (LL); (p < 0.001) as compared to control group. Mycobacterium leprae (M.leprae) were positive in BT-(20%); BB-(72.7%); BL-(83.2%) and LL-(100%). Delayed hypersensitivity reactions (DHR) revealed significantly increased lepromin positivity in TT (83.3%) and BT (80%) which decreased in BB (63.6%) and BL (50%). Lepromin test showed anergic state in LL group (28.5% positivity). Dinitrochlorobenzene (DNCB) skin test showed 100% positivity in TT group and controls while gradual significant decrease was observed from BT (p < 0.05) to LL scale (p < 0.001). Leprosy spectrum of Ridley and Jopling scale is directly co-related with inherent cell mediated immune status of the patients which has a significant prognostic role in treatment and long term management.


Assuntos
Hanseníase/imunologia , Hanseníase/patologia , Adolescente , Adulto , Criança , Feminino , Humanos , Imunidade Celular , Antígeno de Mitsuda , Contagem de Linfócitos , Masculino , Pessoa de Meia-Idade , Prognóstico , Subpopulações de Linfócitos T
12.
Artigo em Inglês | MEDLINE | ID: mdl-20948013
13.
Artigo em Inglês | MEDLINE | ID: mdl-20952891
17.
Indian J Lepr ; 57(2): 364-72, 1985.
Artigo em Inglês | MEDLINE | ID: mdl-4078364

RESUMO

Twenty one patients of leprosy were studied for gastrointestinal symptoms and submitted to detailed intestinal absorption tests and jejunal biopsy before and after the institution of Clofazimine therapy. Fifteen patients were administered 100 mg orally daily for 3 months, while six patients with ENL received 300 mg of the drug for 6 weeks initially and then 100 mg daily. Mild diarrhoea and abdominal symptoms occurred in four patients, fecal fat excretion increased in one patient but Schilling's and d-Xylose tests did not alter. No significant changes were produced by Clofazimine therapy in jejunal mucosa. Clofazimine crystals were seen in the lamina properia of one patient, the overlying mucosa was normal. No correlation was found between the abnormality in mucosal pattern, crystal deposition, absorption parameters or symptomatology and doses of drug taken.


Assuntos
Clofazimina/efeitos adversos , Intestino Delgado/efeitos dos fármacos , Hanseníase/tratamento farmacológico , Adolescente , Adulto , Clofazimina/uso terapêutico , Feminino , Gastroenteropatias/induzido quimicamente , Humanos , Absorção Intestinal/efeitos dos fármacos , Intestino Delgado/metabolismo , Intestino Delgado/patologia , Hanseníase/metabolismo , Masculino , Pessoa de Meia-Idade
18.
Indian J Dermatol Venereol Leprol ; 51(4): 226-228, 1985.
Artigo em Inglês | MEDLINE | ID: mdl-28164970

RESUMO

A 53 year old male having blastomycosis like pyoderma is reted. importance of por differential agnosis rom tuberculosis and -similar entities is discussed.

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