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1.
Fontilles, Rev. leprol ; 30(6): 591-596, sept.-dic. 2016. ilus
Artigo em Espanhol | IBECS | ID: ibc-159089

RESUMO

La lepra puede presentar diversas y complejas manifestaciones clínicas. Las lesiones cutáneas más frecuentemente encontradas son: máculas, pápulas, placas, nódulos y tubérculos. El propósito de esta comunicación es resaltar una forma de presentación atópica de lepra lepromatosa, en un adulto joven de sexo masculino, cuya lesiones iniciales eran pápulas excoriadas en superficie simulando una urticaria papular/prurigo simple. En este caso en particular, la anatomía patológica fue determinante para el diagnóstico correcto. Hacemos hincapié en que la lepra lepromatosa es una «gran simuladora» y los clínicos deberían estar alertas ante estas formas de manifestación rara, que ocurren en ciertas regiones endémicas


Leprosy may have diverse and complex clinical manifestations. Skin lesions most commonly found are: macules, papules, plaques, nodules and tubers. The purpose of this communication is to highlight a form of atypical presentation of lepromatous leprosy, in a young adult male, whose initial lesions were excoriated papules on surface simulating a prurigo/papular urticaria. In this particular case, the pathology was decisive for correct diagnosis. We emphasize that lepromatous leprosy is a great imitator and clinicians should be aware of these rare forms of manifestation, occurring in certain endemic areas


Assuntos
Humanos , Masculino , Adulto Jovem , Hanseníase Virchowiana/patologia , Hanseníase Virchowiana/transmissão , Anormalidades da Pele/patologia , Hanseníase Tuberculoide/patologia , Terapêutica/métodos , Hanseníase Virchowiana/diagnóstico , Hanseníase Virchowiana/metabolismo , Anormalidades da Pele/diagnóstico , Hanseníase Tuberculoide/transmissão , Atletas/classificação , Futebol/classificação , Paraguai/etnologia , Terapêutica
6.
Int. j. lepr. other mycobact. dis ; 68(2): 167-171, Jun., 2000. ilus
Artigo em Inglês | SES-SP, HANSEN, SESSP-ILSLACERVO, SES-SP | ID: biblio-1226945

RESUMO

This is a prospective histomorphological assessment of dermal innervation in biopsies taken before and after multidrug therapy (MDT) from 41 leprosy patients: 35 borderline tuberculoid (BT), 3 borderline lepromatous (BL), 3 lepromatous (LL). Biopsies of the same lesions taken before commencement (diagnostic therapy) and at the end of therapy (check biopsy) were compared. Hematoxylin and eosin, immunoperoxidase stain for S-100 protein, and the Holmes' silver impregnation method for nerve cells and fibers were used. Skin biopsies were classified as having detectable or undetectable nerves. Of 35 patients with BT leprosy, 17 had no detectable nerves in their diagnostic biopsies; in the check biopsies of 13 of these 17, dermal nerves remained undetectable, in 2 they were S-100 positive but were Holmes negative. Identifiable dermal nerves were present in diagnostic biopsies from 18 patients; in the check biopsies 5 of these 18 had no detectable nerves while in the remaining 13 nerve branches could be detected. The study provides histological documentation of complete damage to dermal innervation in 62.85% (22/35) of patients with BT leprosy, of which 14.28% (5/35) occurred during MDT. Of the patients with detectable dermal innervation at the onset of MDT, 27.7% (5/18) suffered continuing damage during MDT.


Assuntos
Anormalidades da Pele/fisiopatologia , Anormalidades da Pele/patologia , Hanseníase/fisiopatologia , Hanseníase/patologia , Hanseníase/tratamento farmacológico
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