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Lepr Rev ; 73(1): 52-63, 2002 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-11969127


An investigation of skin lymphatics in leprosy has been undertaken. Examination of 62 skin biopsies from 31 patients with various classifications of leprosy has revealed dilated initial lymphatics within granulomas of lepromatous leprosy, but no significant abnormalities in non-lepromatous disease or in non-granulomatous skin. Colloidal carbon injected intra-lesionally failed to appear within granulomas, but could be seen in lymphatics in non-granulomatous dermis. Elastic fibres were also absent within granulomas. AFB were clearly identified within endothelial cells of initial lymphatics. We suggest lymphatic malfunction may be compartmental, existing only within the granulomas and not in the surrounding normal appearing dermis.

Hanseníase/diagnóstico , Sistema Linfático/fisiopatologia , Pele/patologia , Carbono , Elasticidade , Feminino , Humanos , Injeções Intravenosas , Hanseníase Virchowiana/diagnóstico , Hanseníase Tuberculoide/diagnóstico , Linfografia/métodos , Masculino , Estudos Prospectivos , Sensibilidade e Especificidade , Índice de Gravidade de Doença , Pele/efeitos dos fármacos
Int J Lepr Other Mycobact Dis ; 62(1): 32-6, 1994 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-8189086


Pedal edema as a possible adverse effect of clofazimine therapy in leprosy was first reported in 1990. Raasch, et al. reported their lymphangiographic findings on ten patients who had clinical lepromatous leprosy in 1969. None of these patients had been on clofazimine therapy. Our study, therefore, was designed to assess the changes that might be seen in the lymphatic system of patients treated with clofazimine for the management of leprosy. Our findings are compared with those of Raasch and his colleagues.

Clofazimina/efeitos adversos , Hanseníase Virchowiana/tratamento farmacológico , Linfedema/induzido quimicamente , Adolescente , Adulto , Humanos , Linfedema/diagnóstico por imagem , Linfografia , Pessoa de Meia-Idade
Lymphology ; 11(3): 93-100, 1978 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-218061


Hepatic lymphography by intra-parenchymal injection of four to ten millilitres (ml) of lipiodol ultrafluid, our modification of functional hepatography, performed on sixty one patients helped study lymphatic dynamics of liver. In conditions associated with significant hepatic venous outflow obstructions, such as hepatic cirrhosis, inflammatory diseases of liver and primary or secondary malignant lesions of the liver, this study delineated liver lymphatics and portal and para aortic lymph nodes. In one case mediastinal nodes were also delineated by flow of lipiodol from the bare area of the liver via trans-diaphragmatic and pleural lymphatic. The lymphangio-architecture of the opacified nodes depicted the nature of pathology inflicting them and the liver. Lipiodol in the lymphatic system, staying longer than the freely diffusible aqueous contrast, provided more detail and better information.

Fígado/diagnóstico por imagem , Linfa/fisiologia , Doença de Hodgkin/diagnóstico por imagem , Humanos , Óleo Iodado , Hanseníase/diagnóstico por imagem , Abscesso Hepático Amebiano/diagnóstico por imagem , Cirrose Hepática/diagnóstico por imagem , Neoplasias Hepáticas/diagnóstico por imagem , Linfografia/métodos