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3.
Int J Dermatol ; 53(6): 746-51, 2014 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-24320966

RESUMO

OBJECTIVES: Most human immunodeficiency virus (HIV)-infected patients develop various skin diseases. These skin manifestations not only act as markers but also reflect the patient's underlying immune status. Investigating CD4 counts is costly and not always possible. Thus, the potential value to be gained by using skin manifestations as predictors of low CD4 counts and disease progression should be explored. The present study attempted to correlate the association of various cutaneous disorders found in HIV patients with CD4 and CD8 counts, the CD4 : CD8 ratio and stage of HIV infection. METHODS: This was a prospective study involving 61 patients who were HIV-positive and demonstrated skin lesions. Punch biopsies of skin were taken for histopathological diagnosis. CD4 and CD8 T cell counts were performed. RESULTS: The study sample included a majority of male patients, most of whom were aged 21-40 years. Pruritic papular dermatitis was the most common skin manifestation, followed by molluscum contagiosum, eosinophilic folliculitis, and Hansen's disease. Most of the lesions were associated with CD4 counts of <220/µl (n = 38). All skin lesions associated with HIV or acquired immune deficiency syndrome (AIDS) showed a CD4 : CD8 ratio of <0.50. CONCLUSIONS: The study findings demonstrate an inverse relationship between CD4 counts and the occurrence of skin lesions. The majority of lesions were associated with stage 3 or stage 4 infection. Thus, specific cutaneous manifestations can be considered as good clinical indicators for predicting underlying immune status in resource-poor countries.


Assuntos
Eosinofilia/patologia , Foliculite/patologia , Infecções por HIV/complicações , Molusco Contagioso/patologia , Infecções Oportunistas/patologia , Dermatopatias Vesiculobolhosas/patologia , Dermatopatias/patologia , Síndrome de Imunodeficiência Adquirida/complicações , Síndrome de Imunodeficiência Adquirida/diagnóstico , Síndrome de Imunodeficiência Adquirida/imunologia , Adulto , Biópsia por Agulha , Contagem de Linfócito CD4 , Estudos de Coortes , Países em Desenvolvimento , Eosinofilia/complicações , Eosinofilia/imunologia , Feminino , Foliculite/complicações , Foliculite/imunologia , Infecções por HIV/diagnóstico , Infecções por HIV/imunologia , Humanos , Hospedeiro Imunocomprometido , Imuno-Histoquímica , Masculino , Pessoa de Meia-Idade , Molusco Contagioso/complicações , Molusco Contagioso/imunologia , Infecções Oportunistas/complicações , Infecções Oportunistas/imunologia , Estudos Prospectivos , Prurido/complicações , Prurido/imunologia , Prurido/patologia , Índice de Gravidade de Doença , Dermatopatias/complicações , Dermatopatias/imunologia , Dermatopatias Vesiculobolhosas/complicações , Dermatopatias Vesiculobolhosas/imunologia , Adulto Jovem
6.
Artigo em Inglês | MEDLINE | ID: mdl-19171985

RESUMO

BACKGROUND: There are numerous therapeutic modalities available for treatment of molluscum contagiosum. However, the ablative modalities are painful and not suitable for children. AIM: We aimed to evaluate and compare the safety and efficacy of 2 of the painless modalities, viz., 5% imiquimod cream and 10% potassium hydroxide (KOH) solution, in the treatment of molluscum contagiosum. METHODS: Out of a total of 40 patients of molluscum contagiosum in the study, 18 patients in the imiquimod group and 19 patients in the KOH group completed the study. The given medication was applied by the patient or a parent to mollusca at night, 3 days per week. Imiquimod was continued till clinical cure; and 10% KOH, till lesions showed signs of inflammation. Assessments of response and side effects were performed at the end of week 4, week 8, and week 12. Significance was tested by Student's t test and Mann-Whitney test. RESULTS: The mean lesion count decreased from 22.39 to 10.75 with imiquimod and from 20.79 to 4.31 with KOH at the end of 12 weeks. We found complete clearance of lesions in 8 (44%) patients with imiquimod and in 8 (42.1%) patients with 10% KOH. Minor side effects were seen in 15 (78.9%) patients on KOH and 10 (55.5%) patients on imiquimod. CONCLUSIONS: The results of this study suggest that both 5% imiquimod cream and 10% KOH solution are equally effective in molluscum contagiosum though KOH has a faster onset of action. However, KOH solution is associated with a higher incidence of side effects.


Assuntos
Aminoquinolinas/administração & dosagem , Hidróxidos/administração & dosagem , Molusco Contagioso/tratamento farmacológico , Compostos de Potássio/administração & dosagem , Administração Tópica , Adolescente , Adulto , Aminoquinolinas/efeitos adversos , Criança , Pré-Escolar , Feminino , Humanos , Hidróxidos/efeitos adversos , Imiquimode , Estudos Longitudinais , Masculino , Molusco Contagioso/patologia , Soluções Farmacêuticas/administração & dosagem , Transtornos da Pigmentação/induzido quimicamente , Compostos de Potássio/efeitos adversos , Resultado do Tratamento , Adulto Jovem
8.
Indian J Lepr ; 77(2): 156-61, 2005.
Artigo em Inglês | MEDLINE | ID: mdl-16044815

RESUMO

A 32-year-old male patient presented with multiple, asymptomatic, papulonodular lesions some of which were umbilicated simulating the clinical features of molluscum contagiosum. On examination the patient was found to be suffering from lepromatous leprosy. Slit-skin smear showed a BI of 6+ and histopathological examination of the nodular lesion showed features of lepromatous leprosy. The patient was treated with MDT-MB and improved remarkably in a few months.


Assuntos
Hanseníase Virchowiana/diagnóstico , Molusco Contagioso/diagnóstico , Adulto , Diagnóstico Diferencial , Histocitoquímica , Humanos , Hansenostáticos/uso terapêutico , Hanseníase Virchowiana/tratamento farmacológico , Hanseníase Virchowiana/patologia , Masculino , Molusco Contagioso/patologia
9.
Indian J Lepr ; 75(1): 53-6, 2003.
Artigo em Inglês | MEDLINE | ID: mdl-15253395

RESUMO

A 23-year old male presented with multiple, asymptomatic, raised lesions of 4 months' duration. The lesions were well demarcated. Dome-shaped papules and nodules were seen on normal looking skin; some were shiny, pearly white and umbilicated. Bilateral greater auricular, ulnar, radial cutaneous and lateral popliteal nerves were thickened. Slit skin smear from an umbilicated nodule had a BI of 6+. Biopsy showed features of lepromatous leprosy.


Assuntos
Hanseníase Virchowiana/patologia , Molusco Contagioso/patologia , Adulto , Humanos , Masculino
11.
Arch. argent. dermatol ; 52(2): 49-55, mar-abr. 2002. ilus
Artigo em Espanhol | BINACIS, BINACIS | ID: bin-7889

RESUMO

El citodiagnóstico, ampliamente difundido, virtualmente carece de aplicación práctica en dermatología. En parte, por las características inherentes al método y además por la particular histoarquitectura de la piel y membranas mucosas sanas y enfermas. Sin embargo, su técnica sencilla puede constituirse en un auxiliar valioso en ciertas dermatosis, en particular vesicoampollares y tumorales. Se revisa éste método diagnóstico y sus limitaciones y se rescatan aquellos casos en los que puede ofrecer utilidad (AU)


Assuntos
Humanos , Citodiagnóstico/estatística & dados numéricos , Técnicas Citológicas/estatística & dados numéricos , Carcinoma Basocelular/diagnóstico , Carcinoma de Células Escamosas/diagnóstico , Melanoma/diagnóstico , Neoplasias Cutâneas/patologia , Dermatopatias Vesiculobolhosas/diagnóstico , Citodiagnóstico/métodos , Técnicas Citológicas/métodos , Dermatologia , Herpes Zoster/patologia , Herpes Simples/patologia , Molusco Contagioso/patologia , Pênfigo/patologia , Carcinoma Basocelular/patologia , Carcinoma de Células Escamosas/patologia , Melanoma/patologia , Neoplasias Cutâneas/diagnóstico , Neoplasias da Mama/secundário , Neoplasias Renais/secundário , Neoplasias Gástricas/secundário , Dermatopatias/diagnóstico , Tuberculose Cutânea/diagnóstico , Dermatomicoses/diagnóstico , Hanseníase/diagnóstico , Pseudolinfoma/diagnóstico
12.
HU rev ; 25/26(3/1): 203-20, set. 1999-abr. 2000. ilus
Artigo em Português | LILACS | ID: lil-296293
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