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2.
Indian J Lepr ; 87(4): 259-265, 2016 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-29762956

RESUMO

Breast tuberculosis (TB) is rare form of extra-pulmonary TB. It is most commonly seen in women of reproductive age group, especially in young, multiparous women who are breast feeding. In geriatric women, breast TB in some cases simulates with breast carcinoma due to common signs which include hard breast lump with nodular surface, ulceration, fixity to skin, discharging sinus, retraction of nipple, axillary lymphadenopathy etc. Hence, it is very difficult to differentiate breast TB from breast cancer, especially in elderly women on clinical ground only, and therefore, histopathological diagnosis is mandatory. Fine needle aspiration cytology is frequently inconclusive due to very small amount of tissue material, and open biopsy or lumpectomy followed by histopathological examination is necessary to confirm the diagnosis of breast TB. Six-month course of anti-tuberculous therapy - ATT (rifampicin, isoniazid, pyrazinamide and ethambutol) is adequate for complete resolution. Here, we report a case of breast TB in an elderly women presenting with left sided breast lump with ulceration of overlying skin and ipsilateral axillary lymphadenopathy. This case of tuberculous mastitis was suspected to be carcinoma due to presence of hard, tender, breast lump with irregular margin, nodular surface, ulceration, purulent discharge and ipsilateral axillary lymphadenopathy in absence of any constitutional symptoms of TB, and heterogenous, hypoechoic mass on USG, which was confirmed by histopathological examination of resected breast lump and responded fully to ATT.


Assuntos
Mama/patologia , Tuberculose/diagnóstico , Idoso , Antituberculosos/administração & dosagem , Biópsia por Agulha Fina , Neoplasias da Mama/patologia , Etambutol/administração & dosagem , Feminino , Humanos , Isoniazida/administração & dosagem , Pirazinamida/administração & dosagem , Rifampina/administração & dosagem , Tuberculose/tratamento farmacológico , Tuberculose/patologia
3.
Rev. esp. patol ; 48(3): 145-153, jul.-sept. 2015. tab, ilus
Artigo em Espanhol | IBECS | ID: ibc-139256

RESUMO

El diagnóstico diferencial de tuberculosis en tejidos fijados en formalina e incluidos en parafina es necesario porque la morfología de la lesión tuberculosa es variada, hay diversos granulomas clasificados en necrobióticos, tuberculoideos, supurativos, sarcoideo, a cuerpo extraño/crónico inespecífico. Las lesiones granulomatosas ocurren en tuberculosis y también en otras infecciones (hongos, parásitos, brucelosis, lepra) en condiciones tóxicas, alérgicas, autoinmunes, tumores y otras. El diagnóstico histológico no es confirmatorio de tuberculosis y en ausencia de una baciloscopia positiva, se hace necesaria la confirmación molecular para el diagnóstico diferencial. Evaluamos la eficacia de la técnica de PCR para la detección de tuberculosis en tejidos fijados y comparamos esos resultados con la histología del granuloma y la baciloscopia. Analizamos 444 biopsias de diferentes tejidos (ganglios, piel, pleura, pulmón, intestino, tejido óseo, mama y otros) de 5 tipos de granulomas: G1.tuberculoideo con necrosis caseosa; G2.tuberculoideo sin necrosis caseosa; G3. supurativo; G4. sarcoideo l; G5. a cuerpo extraño/inespecífico. Utilizamos dos PCR-IS6110 nested para detección del complejo Mycobacterium tuberculosis y un pan PCR-hsp65 nested para detección de Mycobacterium spp. Los resultados obtenidos muestran que la detección de tuberculosis mediante PCR fue significativamente superior que mediante baciloscopia. G1: PCR 69,6%, baciloscopia 31,3%; G2: PCR 26,8%, baciloscopia 6,1%; G3: PCR 16,7%, baciloscopia 6,7%; G4: PCR 7%, baciloscopia 4%; G5: PCR 6,7%, baciloscopia 0%. Concluimos que el diagnóstico molecular de tuberculosis mediante un PCR robusto adaptado a tejidos fijados es eficaz, rápido, sensible y contribuye a la precisión del diagnóstico diferencial en diferentes tipos de granulomas (AU)


The differential diagnosis of tuberculosis in fixed paraffin embedded-tissues is necessary due to both the diverse morphology of tuberculous lesions and the varying histological types of granulomas (necrobiotic, tuberculoid, suppurative, sarcoidal and foreign body/inespecific). Granulomatous lesions occur in tuberculosis, in other infections (fungal, parasitic, brucelosis, lepra), in toxic, allergic and autoimmune, tumours and in conditions of unknown etiology. Diagnosis of tuberculosis cannot be confirmed by histopathology alone and in absence of a positive acid-fast bacilli (AFB) stain, molecular confirmation of tuberculosis is necessary for a correct differential diagnosis. The aim of our study was to assess PCR efficacy for mycobacterial infection detection in fixed tissues and to correlate those findings with granuloma histology and with AFB staining. We analyzed 444 biopsies from various tissues (lymph nodes, skin, pleura, lung, intestine, bone tissue, breast and others) with 5 granuloma types: G1: with caseous necrosis; G2: without caseous necrosis; G3: suppurative; G4: sarcoidal; G5: chronic/nonspecific. For molecular detection, we used nested PCR-IS6110 for Mycobacterium tuberculosis complex and a nested pan PCR-hsp65 for Mycobacterium sp.. The results obtained demonstrated that PCR was significantly better than AFB stain for tuberculosis detection. G1: PCR 69.6%, AFB staining 31.3%. G2: PCR 26.8%, AFB staining 6.1%; G3: PCR 16.7%, AFB staining 6.7%; G4: PCR 7%, AFB staining 4%. G5: PCR 6.7%, AFB staining 0%. We conclude that molecular diagnosis of tuberculosis using robust PCR-based testing adapted to fixed tissues is a fast, efficient and sensitive method that increases the accuracy of the differential diagnosis of granulomatous lesions (AU)


Assuntos
Feminino , Humanos , Masculino , Tuberculose/diagnóstico , Tuberculose/patologia , Reação em Cadeia da Polimerase/instrumentação , Reação em Cadeia da Polimerase , Diagnóstico Diferencial , Granuloma/classificação , Granuloma/patologia , Biópsia/instrumentação , Biópsia/métodos , Mycobacterium tuberculosis/isolamento & purificação , Estudos Prospectivos , DNA/análise
4.
Cell Physiol Biochem ; 35(4): 1276-88, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-25721573

RESUMO

BACKGROUND: The early secreted antigenic target 6-kDa protein (ESAT-6) of Mycobacterium tuberculosis (Mtb) not only acts as a key player for virulence but also exhibits a strong immunotherapeutic potential against Mtb. However, little is known about the molecular basis for its potential in immunotherapy. The present study was designed to unravel the role of miRNA-155 in ESAT-6-mediated enhancement of host immunity and apoptosis in macrophages. METHODS: Lentivirus-mediated miR-155 sponge and miR-155 and SOCS1 overexpression vectors were developed in macrophages. TLR2- or p65-specific siRNA knockdown was employed to silence TLR2 or p65. Quantitative polymerase chain reaction and western blotting analyses were performed to determine mRNA and protein expression levels, respectively. Macrophage apoptosis was analyzed by flow cytometry. RESULTS: ESAT-6 significantly increased miR-155 expression, which was dependent on TLR2/NF-κB activation in macrophages. Induced expression of miRNA-155 was required for the ESAT-6-mediated protective immune response and macrophage apoptosis. ESAT-6 promoted macrophage apoptosis by targeting the miR-155-SOCS1 pathway. The differential expression levels of TLR2, BIC, and SOCS1 were involved in regulating the immune response in human peripheral blood mononuclear cells of patients with active tuberculosis (TB) and latent TB (LTB). CONCLUSION: ESAT-6 promotes apoptosis of macrophages via targeting the miRNA155-SOCS1 interaction.


Assuntos
Antígenos de Bactérias/farmacologia , Apoptose/efeitos dos fármacos , MicroRNAs/metabolismo , Mycobacterium tuberculosis/metabolismo , Proteínas Supressoras da Sinalização de Citocina/metabolismo , Tuberculose/patologia , Animais , Antígenos de Bactérias/genética , Antígenos de Bactérias/metabolismo , Linhagem Celular , Humanos , Interleucina-6/genética , Interleucina-6/metabolismo , Leucócitos Mononucleares/metabolismo , Macrófagos/citologia , Macrófagos/efeitos dos fármacos , Macrófagos/metabolismo , Camundongos , Interferência de RNA , Proteínas Recombinantes/biossíntese , Proteínas Recombinantes/genética , Proteínas Recombinantes/farmacologia , Proteínas Supressoras da Sinalização de Citocina/genética , Receptor 2 Toll-Like/antagonistas & inibidores , Receptor 2 Toll-Like/genética , Receptor 2 Toll-Like/metabolismo , Fator de Transcrição RelA/antagonistas & inibidores , Fator de Transcrição RelA/genética , Fator de Transcrição RelA/metabolismo , Tuberculose/metabolismo , Fator de Necrose Tumoral alfa/genética , Fator de Necrose Tumoral alfa/metabolismo
5.
Nature ; 501(7468): 512-6, 2013 Sep 26.
Artigo em Inglês | MEDLINE | ID: mdl-24005326

RESUMO

Ubiquitin-mediated targeting of intracellular bacteria to the autophagy pathway is a key innate defence mechanism against invading microbes, including the important human pathogen Mycobacterium tuberculosis. However, the ubiquitin ligases responsible for catalysing ubiquitin chains that surround intracellular bacteria are poorly understood. The parkin protein is a ubiquitin ligase with a well-established role in mitophagy, and mutations in the parkin gene (PARK2) lead to increased susceptibility to Parkinson's disease. Surprisingly, genetic polymorphisms in the PARK2 regulatory region are also associated with increased susceptibility to intracellular bacterial pathogens in humans, including Mycobacterium leprae and Salmonella enterica serovar Typhi, but the function of parkin in immunity has remained unexplored. Here we show that parkin has a role in ubiquitin-mediated autophagy of M. tuberculosis. Both parkin-deficient mice and flies are sensitive to various intracellular bacterial infections, indicating parkin has a conserved role in metazoan innate defence. Moreover, our work reveals an unexpected functional link between mitophagy and infectious disease.


Assuntos
Drosophila melanogaster/imunologia , Drosophila melanogaster/microbiologia , Imunidade Inata/imunologia , Mycobacterium marinum/imunologia , Mycobacterium tuberculosis/imunologia , Salmonella typhimurium/imunologia , Ubiquitina-Proteína Ligases/imunologia , Animais , Autofagia/imunologia , Células da Medula Óssea/microbiologia , Drosophila melanogaster/genética , Drosophila melanogaster/metabolismo , Feminino , Lisina/metabolismo , Macrófagos/microbiologia , Masculino , Camundongos , Camundongos Endogâmicos C57BL , Mitocôndrias/metabolismo , Mitocôndrias/patologia , Mitofagia , Modelos Imunológicos , Mycobacterium tuberculosis/crescimento & desenvolvimento , Mycobacterium tuberculosis/metabolismo , Poliubiquitina/química , Poliubiquitina/metabolismo , Simbiose/imunologia , Tuberculose/enzimologia , Tuberculose/imunologia , Tuberculose/microbiologia , Tuberculose/patologia , Ubiquitina/análise , Ubiquitina/química , Ubiquitina/metabolismo , Ubiquitina-Proteína Ligases/química , Ubiquitina-Proteína Ligases/deficiência , Ubiquitina-Proteína Ligases/metabolismo
6.
Expert Rev Anti Infect Ther ; 9(6): 701-10, 2011 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-21692674

RESUMO

An increase in leprosy among HIV patients, similar to that observed in patients with TB, was expected approximately 20 years ago. Studies conducted in the 1990s together with those reported recently seemed to indicate that a coinfection with HIV did not alter the incidence and the clinical spectrum of leprosy and that each disease progressed as a single infection. By contrast, in countries with a high seroprevalence of HIV, TB was noted to increase. Explanations may be provided by the differences in the incubation time, the biology and toxicity of Mycobacterium leprae and Mycobacterium tuberculosis. After the introduction of HAART the leprosy-HIV coinfection manifested itself as an immune reconstitution inflammatory syndrome (IRIS), typically as paucibacillary leprosy with type 1 leprosy reaction. The incidence of leprosy in HIV-infected patients has never been properly investigated. IRIS-leprosy is probably underestimated and recent data showed that the incidence of leprosy in HIV patients under HAART was higher than previously thought.


Assuntos
Terapia Antirretroviral de Alta Atividade/efeitos adversos , Infecções por HIV/virologia , Síndrome Inflamatória da Reconstituição Imune/patologia , Hanseníase/microbiologia , Tuberculose/microbiologia , Antibacterianos/uso terapêutico , Antivirais/uso terapêutico , Comorbidade , HIV/fisiologia , Infecções por HIV/diagnóstico , Infecções por HIV/tratamento farmacológico , Infecções por HIV/epidemiologia , Infecções por HIV/imunologia , Infecções por HIV/patologia , Humanos , Síndrome Inflamatória da Reconstituição Imune/diagnóstico , Síndrome Inflamatória da Reconstituição Imune/tratamento farmacológico , Síndrome Inflamatória da Reconstituição Imune/epidemiologia , Síndrome Inflamatória da Reconstituição Imune/imunologia , Incidência , Hanseníase/diagnóstico , Hanseníase/tratamento farmacológico , Hanseníase/epidemiologia , Hanseníase/imunologia , Hanseníase/patologia , Mycobacterium leprae/fisiologia , Mycobacterium tuberculosis/fisiologia , Especificidade da Espécie , Tuberculose/diagnóstico , Tuberculose/tratamento farmacológico , Tuberculose/epidemiologia , Tuberculose/imunologia , Tuberculose/patologia
7.
Scand J Immunol ; 71(2): 63-9, 2010 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-20384857

RESUMO

A new tuberculosis vaccine is urgently needed. Prime-boost strategies are considered very promising and the inclusion of BCG is highly desirable. In this investigation, we tested the protective efficacy of BCG delivered in the neonatal period followed by boosters in the adult phase with a DNA vaccine containing the hsp65 gene from Mycobacterium leprae (pVAXhsp65). Immune responses were characterized by serum anti-hsp65 antibody levels and IFN-gamma and IL-5 production by the spleen. Amounts of these cytokines were also determined in lung homogenates. Protective efficacy was established by the number of colony-forming units (CFU) and histopathological analysis of the lungs after challenge with Mycobacterium tuberculosis. Immunization with BCG alone triggered a significant reduction of CFU in the lungs and also clearly preserved the pulmonary parenchyma. BCG priming also increased the immunogenicity of pVAXhsp65. However, boosters with pVAXhsp65 or the empty vector abolished the protective efficacy of BCG. Also, higher IL-5 levels were produced by spleen and lungs after DNA boosters. These results demonstrated that neonatal BCG immunization followed by DNAhsp65 boosters is highly immunogenic but is not protective against tuberculosis.


Assuntos
Vacina BCG/imunologia , Proteínas de Bactérias/imunologia , Chaperonina 60/imunologia , Imunização Secundária/métodos , Tuberculose/imunologia , Tuberculose/prevenção & controle , Animais , Animais Recém-Nascidos , Anticorpos Antibacterianos/sangue , Anticorpos Antibacterianos/imunologia , Antígenos de Bactérias/imunologia , Citocinas/biossíntese , Citocinas/imunologia , Camundongos , Camundongos Endogâmicos BALB C , Tuberculose/patologia , Vacinas de DNA/imunologia
8.
Nihon Hansenbyo Gakkai Zasshi ; 78(3): 263-9, 2009 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-19803377

RESUMO

When Mycobacterium tuberculosis infects humans, about 20% of those infected actually develop tuberculosis (TB). In Japan, the incidence of TB in 2008 was 24,760 cases (19.4/100,000 persons) and the rate has been decreasing gradually, but is still higher than in the USA, Holland, and Belgium, for example. Histologically, tuberculosis displays exudative inflammation, proliferative inflammation and productive inflammation depending on the time course. In productive inflammation, granulomatous lesions with necrotic centers are formed. The typical granulomas consist of epithelioid macrophages, Langhans' multinucleated giant cells, lymphocytes and fibroblasts, and the process of their formation involves many cytokines, chemokines and transcription factors. These findings have been derived primarily from animal experiments utilizing an airborne infection apparatus. The conditions for airborne infection have been described in detail elsewhere. This mini-review focuses on what has been found through animal experiments, and also indicates areas for which data are not currently available.


Assuntos
Inflamação/etiologia , Tuberculose/complicações , Animais , Apoptose/fisiologia , Parede Celular , DNA Bacteriano , Genoma Bacteriano , Células Gigantes de Langhans/imunologia , Humanos , Sistema Imunitário/imunologia , Inflamação/patologia , Interferon gama/fisiologia , Macrófagos Alveolares/imunologia , Mycobacterium tuberculosis/citologia , Mycobacterium tuberculosis/genética , Neutrófilos/imunologia , Óxido Nítrico/fisiologia , Fatores de Risco , Tuberculose/imunologia , Tuberculose/patologia , Fator de Necrose Tumoral alfa/fisiologia
9.
Clin Exp Dermatol ; 28(3): 245-50, 2003 May.
Artigo em Inglês | MEDLINE | ID: mdl-12780703

RESUMO

Chronic macrocheilia has a multifactorial aetiology and is often a diagnostic and therapeutic challenge. Epidemiological information on this condition is scarce, most of the data reported relating only to granulomatous cheilitis. We have performed a detailed clinico-pathological analysis of all patients with chronic macrocheilia presenting to us during the last 6.5 years. Of the 28 patients identified, 13 (46.4%) had granulomatous cheilitis (GC), six (21.4%) had tuberculosis of the lip, three (10.7%) had leprous macrocheilia, two (7.1%) had multiple endocrine neoplasia type IIb, and one each had Ascher's syndrome and non-Hodgkin's lymphoma. Two patients were diagnosed as 'nonspecific cheilitis'. Histopathological differentiation between tuberculosis and GC was often not possible; but PCR for Mycobacterium tuberculosis was positive in all patients with tuberculosis and negative in four patients with GC in whom M. tuberculosis was sought. In spite of detailed clinical examination and investigations, a therapeutic trial was required to confirm the diagnosis in five (17.9%) patients. We have reviewed the available literature on this subject, and to our knowledge this study is the first of its kind. More such studies from other centres will help physicians to make an accurate aetiological diagnosis and treat this uncommon but disfiguring condition with confidence.


Assuntos
Doenças Labiais/patologia , Adolescente , Adulto , Queilite/patologia , Criança , Doença Crônica , Feminino , Granuloma/patologia , Humanos , Hanseníase/patologia , Neoplasias Labiais/patologia , Linfoma não Hodgkin/patologia , Masculino , Pessoa de Meia-Idade , Neoplasia Endócrina Múltipla Tipo 2b/patologia , Estudos Retrospectivos , Tuberculose/patologia
10.
Microbes Infect ; 5(7): 677-84, 2003 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-12787744

RESUMO

More than one century after the discovery of their etiological agents, tuberculosis and leprosy remain as major health threats for humans, and the molecular mechanisms that lead to the development of both diseases are poorly understood. The elucidation of these mechanisms, and especially those allowing for the mycobacteria to systemically disseminate, should facilitate the development of new prophylactic and/or therapeutic strategies. This review is focused on the routes that Mycobacterium tuberculosis and Mycobacterium leprae may use to disseminate within the human body, and the potential roles played by recently characterized adhesins in this process.


Assuntos
Adesinas Bacterianas/fisiologia , Hanseníase/microbiologia , Mycobacterium leprae/patogenicidade , Mycobacterium tuberculosis/patogenicidade , Tuberculose/microbiologia , Humanos , Hanseníase/patologia , Mycobacterium leprae/ultraestrutura , Mycobacterium tuberculosis/ultraestrutura , Tuberculose/patologia
12.
Res Microbiol ; 153(5): 301-5, 2002 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-12160321

RESUMO

The immuno-dot-blot assay MycoDot, which detects lipoarabinomannan (LAM) antibodies, was evaluated for the serological diagnosis of active pulmonary tuberculosis in patients in a rural community in the Republic of Guinea-Bissau. Sera from 269 adults (age > 15) and 33 children (age < 5) were assayed for antibodies in a blind manner and the results compared to the clinical status of tuberculosis. The assay had a specificity and a sensitivity of 92.4% and 63.0% respectively, when applied to the adult population. In HIV-2 infected individuals (27/269), the specificity and sensitivity of the assay were similar, 94.7% and 62.5% respectively. The assay did not provide high sensitivity for the diagnosis of tuberculosis in children. Sera from patients with leprosy cross-reacted with the antigen of the assay. It is concluded that this easily performed assay may be useful for the presumptive diagnosis of tuberculosis in adult populations in rural areas of developing countries where routine screening is not readily available.


Assuntos
Infecções por HIV/complicações , HIV-2 , Immunoblotting/métodos , Mycobacterium tuberculosis/isolamento & purificação , Tuberculose/diagnóstico , Adolescente , Adulto , Anticorpos Antibacterianos/sangue , Criança , Pré-Escolar , Guiné-Bissau , Humanos , Lipopolissacarídeos , População Rural , Sensibilidade e Especificidade , Tuberculose/complicações , Tuberculose/patologia , Tuberculose/virologia
13.
s.l; s.n; 2002. 5 p. tab.
Não convencional em Inglês | SES-SP, SES-SP, HANSEN, HANSENIASE, SESSP-ILSLACERVO, SES-SP | ID: biblio-1240942

RESUMO

The immuno-dot-blot assay MycoDot, which detects lipoarabinomannan (LAM) antibodies, was evaluated for the serological diagnosis of active pulmonary tuberculosis in patients in a rural community in the Republic of Guinea-Bissau. Sera from 269 adults (age > 15) and 33 children (age < 5) were assayed for antibodies in a blind manner and the results compared to the clinical status of tuberculosis. The assay had a specificity and a sensitivity of 92.4 per cent and 63.0 per cent respectively, when applied to the adult population. In HIV-2 infected individuals (27/269), the specificity and sensitivity of the assay were similar, 94.7 per cent and 62.5 per cent respectively. The assay did not provide high sensitivity for the diagnosis of tuberculosis in children. Sera from patients with leprosy cross-reacted with the antigen of the assay. It is concluded that this easily performed assay may be useful for the presumptive diagnosis of tuberculosis in adult populations in rural areas of developing countries where routine screening is not readily available.


Assuntos
Humanos , Pré-Escolar , Criança , Adulto , Adolescente , HIV-2 , Anticorpos Antibacterianos/sangue , Guiné-Bissau , Immunoblotting/métodos , Infecções por HIV/complicações , Lipopolissacarídeos , Mycobacterium tuberculosis/isolamento & purificação , População Rural , Sensibilidade e Especificidade , Tuberculose/complicações , Tuberculose/diagnóstico , Tuberculose/patologia , Tuberculose/virologia
14.
Scand J Immunol ; 54(6): 630-9, 2001 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-11902340

RESUMO

To study the location and mechanism of apoptosis within the human tuberculosis (TB) and leprosy lesions, parallel sections were analyzed for mycobacterial antigens (M.Ag), Fas ligand (FasL), Fas, CD68 and Mac387 by immunohistochemistry, and apoptotic cells by the terminal deoxynucleotidyl-transferase-mediated dUTP-digoxigenin nick end labelling method. Cutaneous leishmaniasis and foreign body granulomas were analyzed for comparison. The heavily infected macrophages in multibacillary TB and leprosy granulomas very strongly expressed FasL, indicating that a mycobacterial infection can induce an increased expression of FasL in a population of infected macrophages, which may protect them from the attack of Fas-expressing lymphocytes. However, macrophages with high levels of leishmania amastigotes did not selectively express FasL, suggesting that this phenomenon is specific for the mycobacteria. Interestingly, in the well-formed TB granulomas, 84% of the multinucleated giant cells strongly expressed FasL. The expression of Fas was weak (34%) or absent. A higher number (33%) of epithelioid cells expressed FasL than Fas (23%). Lymphocytes were scanty among the epithelioid cells. The frequency of apoptotic cells was higher in the epithelioid cells (0.25%) than the mononuclear cells in the mantle zone (0.14%). Thus, the epithelioid cells and the multinucleated giant cells by virtue of the increased expression of FasL may make these granulomas an immune privileged site for mycobacteria.


Assuntos
Hanseníase/imunologia , Glicoproteínas de Membrana/metabolismo , Tuberculose/imunologia , Antígenos de Bactérias/metabolismo , Antígenos CD/metabolismo , Antígenos de Diferenciação Mielomonocítica/metabolismo , Apoptose , Proteína Ligante Fas , Granuloma de Corpo Estranho/imunologia , Granuloma de Corpo Estranho/patologia , Imuno-Histoquímica , Leishmaniose Cutânea/imunologia , Leishmaniose Cutânea/patologia , Hanseníase/microbiologia , Hanseníase/patologia , Modelos Imunológicos , Mycobacterium leprae/imunologia , Mycobacterium tuberculosis/imunologia , Tuberculose/microbiologia , Tuberculose/patologia , Receptor fas/metabolismo
18.
Buenos Aires; Academia Nacional de Ciencias de Buenos Aires; 1998. 41 p. (4309).
Monografia em Espanhol | BINACIS, BINACIS | ID: bin-4309
19.
Int Arch Allergy Immunol ; 113(4): 400-8, 1997 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-9250585

RESUMO

Mycobacterial infections represent major problems to global health care. Tuberculosis is feared particularly because of its high mortality rates whereas in leprosy the occurrence of immunopathology, particularly nerve damage, is a major problem since the bacillus itself is relatively harmless. Thus, both effective vaccination strategies as well as novel immunomodulating regimens are warranted for the control of morbidity and mortality in mycobacterial diseases. Since CD4+ Th1 cells and type-1 cytokines play a key role both in protective immunity and immunopathology in mycobacterial infections, we here describe new pharmacological and cytokine-based strategies to regulate Th1 immunity.


Assuntos
Imunidade Ativa , Infecções por Mycobacterium/imunologia , Infecções por Mycobacterium/patologia , Animais , Antígenos CD4/imunologia , Antígenos CD4/metabolismo , Linfócitos T CD8-Positivos/imunologia , Citocinas/imunologia , Citocinas/metabolismo , Humanos , Imunidade Celular , Hanseníase/imunologia , Hanseníase/patologia , Hanseníase/prevenção & controle , Camundongos , Infecções por Mycobacterium/prevenção & controle , Células Th1/imunologia , Células Th1/metabolismo , Tuberculose/imunologia , Tuberculose/patologia , Tuberculose/prevenção & controle , Vacinas/imunologia
20.
Brain Pathol ; 7(1): 629-47, 1997 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-9034570

RESUMO

The organisms that produce bacterial infections of the nervous system in tropical regions are similar to those existing in the rest of the world. However, because of poor socio-economic conditions in the former areas, preventing the implementation of appropriate prophylactic and therapeutic measures, the incidence and course of these diseases may vary. In this paper the neuropathological appearances of the main bacterial diseases are reviewed and the main differences between those occurring in developed and developing countries emphasized. Despite great efforts by governments and communities, tuberculosis still remains a scourge in many countries and leprosy has not been eradicated from earth. Earlier optimism that antibiotics could finally put an end to syphilis have been dashed and the disease still persists. Moreover, the explosion of AIDS not only has produced a recrudescence of many of these diseases, but has also changed their clinical and pathological presentation.


Assuntos
Infecções Bacterianas/patologia , Encefalopatias/patologia , Países Desenvolvidos , Países em Desenvolvimento , Encefalopatias/microbiologia , Humanos , Hanseníase Tuberculoide/patologia , Hanseníase Tuberculoide/fisiopatologia , Meningites Bacterianas/etiologia , Meningites Bacterianas/patologia , Meningites Bacterianas/fisiopatologia , Neurossífilis/patologia , Tuberculose/patologia
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