Clindamycin lotion alone versus combination lotion of clindamycin phosphate plus tretinoin versus combination lotion of clindamycin phosphate plus salicylic acid in the topical treatment of mild to moderate acne vulgaris: a randomized control trial.
Indian J Dermatol Venereol Leprol
; 75(3): 279-82, 2009.
Article
in En
| MEDLINE
| ID: mdl-19439881
ABSTRACT
BACKGROUND:
Acne vulgaris is a common skin disease that affects 85% to 100% of people at some time during their lives. It is characterized by noninflammatory follicular papules or comedones and by inflammatory papules, pustules, and nodules in its more severe forms.AIMS:
To compare the efficacy of combination treatment of clindamycin+salicylic acid, versus clindamycin+tretinoin versus clindamycin alone in the treatment of the mild-to-moderate acne vulgaris.METHODS:
This was a single-blinded, randomized clinical trial.Forty-two female patients (age range 15-25 years) with mild-to-moderate acne vulgaris were selected randomly and subsequently randomized to 3 groups. Group A patients were treated with 1% clindamycin lotion (C lotion) twice daily. Group B patients were treated with 1% clindamycin+0.025% tretinoin lotion once nightly (CT lotion). Group C patients were treated with 1% clindamycin+2% salicylic acid lotion twice daily (CS lotion) for 12 weeks. For comparison of efficacy of these treatments, and regarding the skewed distribution of the data, Kruskal-Wallis Test and Mann-Whitney U test were used. SPSS software was used for statistical analysis.RESULTS:
There was a significant difference between 3 types of treatment in the respect of the total lesion count (TLC) improvement (P = 0.039). The efficacy of treatment on Acne Severity Index (ASI) was maximum for CS lotion (81.80% reduction in ASI). CT lotion reduced ASI by as much as 73.73% during 12 weeks of treatment. The efficacy of C lotion was calculated to be 37.87% in the reduction of ASI.CONCLUSIONS:
Our data suggested that the efficacy of CS lotion was significantly more than C lotion with respect to the TLC and ASI, although there was no significant difference between CS and CT lotion.
Full text:
1
Theme:
Complicacoes
/
Geral
/
Prevencao_controle
/
Tratamento_medicamentoso
Database:
MEDLINE
Main subject:
Tretinoin
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Clindamycin
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Acne Vulgaris
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Salicylic Acid
Type of study:
Clinical_trials
Language:
En
Journal:
Indian J Dermatol Venereol Leprol
Year:
2009
Document type:
Article