Evaluation of the expression of interleukin 1 beta (IL-1beta) and interleukin 1 receptor antagonist (IL-1Ra) in leprosy patients.
Rev Soc Bras Med Trop
; 41 Suppl 2: 99-103, 2008.
Article
in En
| MEDLINE
| ID: mdl-19618085
ABSTRACT
Leprosy is an infectious and contagious spectral disease accompanied by a series of immunological events triggered by the host's response to the etiologic agent, Mycobacterium leprae. Evidence suggests that the induction and maintenance of the immune/inflammatory response in leprosy are linked to multiple cell interactions and soluble factors, mainly through the action of cytokines. The ELISA test was used to measure the levels of IL-1beta and IL-1Ra in 37 new leprosy patients followed-up during treatment and 30 healthy controls. Peripheral blood was collected four times during the treatment of leprosy patients (MDT pretreatment, 2nd dose, 6th dose and post-MDT), and only once from the controls. The comparison of molecular levels in pre-MDT patients and controls showed a statistically significant difference for IL-1beta. The results suggest the participation of this cytokine in the genesis of the immune/inflammatory process.
Full text:
1
Theme:
Complicacoes
/
Geral
/
Tratamento_medicamentoso
Database:
MEDLINE
Main subject:
Interleukin 1 Receptor Antagonist Protein
/
Interleukin-1beta
/
Leprosy
Type of study:
Observational_studies
/
Prognostic_studies
Language:
En
Journal:
Rev Soc Bras Med Trop
Year:
2008
Document type:
Article