Transmission of dapsone-resistant leprosy detected by molecular epidemiological approaches.
Antimicrob Agents Chemother
; 55(11): 5384-7, 2011 Nov.
Article
in En
| MEDLINE
| ID: mdl-21859943
ABSTRACT
Drug resistance surveillance identified six untreated leprosy patients in the Philippines with Mycobacterium leprae folP1 mutations which confer dapsone resistance. Five patients share a village of residence; four who carried the mutation, Thr53Val, were also linked by M. leprae variable-number tandem repeat (VNTR) strain types. In India, folP1 mutations were detected in two relapse patients with a history of dapsone treatment. Mutations were not found in the rifampin target gene rpoB. These findings indicate that dapsone resistance is being transmitted.
Full text:
1
Theme:
Complicacoes
/
Epidemiologia
/
Geral
/
Transmissao
/
Tratamento_medicamentoso
Database:
MEDLINE
Main subject:
Molecular Epidemiology
/
Dapsone
/
Leprostatic Agents
/
Leprosy
/
Mycobacterium leprae
Type of study:
Prognostic_studies
Country/Region as subject:
Asia
Language:
En
Journal:
Antimicrob Agents Chemother
Year:
2011
Document type:
Article