Excavating the surface-associated and secretory proteome of Mycobacterium leprae for identifying vaccines and diagnostic markers relevant immunodominant epitopes.

Rana, Aarti; Thakur, Shweta; Bhardwaj, Nupur; Kumar, Devender; Akhter, Yusuf

Rana, Aarti; Thakur, Shweta; Bhardwaj, Nupur; Kumar, Devender; Akhter, Yusuf.

Affiliation

Rana A; School of Life Sciences, Central University of Himachal Pradesh, Shahpur, District-Kangra, Himachal Pradesh-176206, India.
Thakur S; School of Life Sciences, Central University of Himachal Pradesh, Shahpur, District-Kangra, Himachal Pradesh-176206, India.
Bhardwaj N; School of Life Sciences, Central University of Himachal Pradesh, Shahpur, District-Kangra, Himachal Pradesh-176206, India.
Kumar D; School of Life Sciences, Central University of Himachal Pradesh, Shahpur, District-Kangra, Himachal Pradesh-176206, India.
Akhter Y; School of Life Sciences, Central University of Himachal Pradesh, Shahpur, District-Kangra, Himachal Pradesh-176206, India yusuf@daad-alumni.de.

Pathog Dis ; 74(9)2016 12.

Article in En | MEDLINE | ID: mdl-27856491

Subject(s)

Antigens, Bacterial/immunology; Bacterial Proteins/immunology; Leprosy/immunology; Membrane Proteins/immunology; Mycobacterium leprae/immunology; Proteome; Antigens, Bacterial/chemistry; Bacterial Proteins/chemistry; Bacterial Vaccines/immunology; Biomarkers; Epitopes, B-Lymphocyte/immunology; Epitopes, T-Lymphocyte/chemistry; Epitopes, T-Lymphocyte/immunology; Histocompatibility Antigens Class II/genetics; Histocompatibility Antigens Class II/immunology; Histocompatibility Antigens Class II/metabolism; Humans; Immunodominant Epitopes/chemistry; Immunodominant Epitopes/immunology; Immunotherapy; Leprosy/diagnosis; Leprosy/microbiology; Leprosy/prevention & control; Membrane Proteins/chemistry; Mycobacterium leprae/metabolism

Key words

Mycobacterium leprae; antigen; diagnostic markers; epitopes; outer membrane proteins; vaccine

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Theme: Complicacoes / Geral / Prevencao_controle / Tratamento_medicamentoso Database: MEDLINE Main subject: Bacterial Proteins / Proteome / Leprosy / Membrane Proteins / Mycobacterium leprae / Antigens, Bacterial Type of study: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Language: En Journal: Pathog Dis Year: 2016 Document type: Article

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