Tectona grandis leaf extract ameliorates hepatic fibrosis: Modulation of TGF- ß /Smad signaling pathway and upregulating MMP3/TIMP1 ratio.

Tariq, Somayya; Koloko, Brice Landry; Malik, Ayesha; Rehman, Sidra; Ijaz, Bushra; Shahid, Ahmad Ali

Tariq, Somayya; Koloko, Brice Landry; Malik, Ayesha; Rehman, Sidra; Ijaz, Bushra; Shahid, Ahmad Ali.

Affiliation

Tariq S; Centre of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan. Electronic address: somayyatariq@hotmail.com.
Koloko BL; Centre of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan. Electronic address: kobriland@yahoo.fr.
Malik A; Centre of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan. Electronic address: ayesha.malik9846@gmail.com.
Rehman S; Department of Biosciences, COMSATS University Islamabad, Islamabad, Pakistan. Electronic address: sidra.cemb@gmail.com.
Ijaz B; Centre of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan. Electronic address: bijaz@cemb.edu.pk.
Shahid AA; Centre of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan. Electronic address: ahmadali.shahid@googlemail.com.

J Ethnopharmacol ; 272: 113938, 2021 May 23.

Article in En | MEDLINE | ID: mdl-33610708

Subject(s)

Lamiaceae/chemistry; Liver Cirrhosis/prevention & control; Matrix Metalloproteinase 3/metabolism; Protective Agents/pharmacology; Protective Agents/poisoning; Signal Transduction/drug effects; Smad2 Protein/metabolism; Tissue Inhibitor of Metalloproteinase-1/metabolism; Transforming Growth Factor beta/metabolism; Animals; Carbon Tetrachloride/toxicity; Cell Survival/drug effects; Chlorocebus aethiops; Collagen/metabolism; Disease Models, Animal; Dose-Response Relationship, Drug; Hep G2 Cells; Hepatic Stellate Cells/drug effects; Humans; Liver Cirrhosis/chemically induced; Liver Cirrhosis/metabolism; Liver Cirrhosis/pathology; Matrix Metalloproteinase 3/genetics; Mice, Inbred C57BL; Plant Extracts/administration & dosage; Plant Extracts/chemistry; Plant Extracts/pharmacology; Plant Leaves/chemistry; Protective Agents/chemistry; Smad2 Protein/genetics; Tissue Inhibitor of Metalloproteinase-1/genetics; Transaminases/blood; Transforming Growth Factor beta/genetics; Vero Cells

Key words

CCl(4) induced liver injury; Hepatoprotectivity; Liver fibrosis; Medicinal plant; Methanol extract; TGF-ß1/Smad pathway; Tectona grandis L.f

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Full text: 1 Theme: Geral / Prevencao_controle Database: MEDLINE Main subject: Signal Transduction / Transforming Growth Factor beta / Matrix Metalloproteinase 3 / Lamiaceae / Tissue Inhibitor of Metalloproteinase-1 / Protective Agents / Smad2 Protein / Liver Cirrhosis Type of study: Prognostic_studies Language: En Journal: J Ethnopharmacol Year: 2021 Document type: Article

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