Effect of T-cell depletion on bacterial multiplication and pattern of nerve damage in M. leprae-infected mice.
Indian J Lepr
; 67(4): 363-74, 1995.
Article
in En
| MEDLINE
| ID: mdl-8849913
ABSTRACT
Various mechanisms for nerve damage in tuberculoid leprosy have been proposed. A common feature amongst them is the crucial role played by T-cells. Therefore, the present study was designed to determine the role of T-cells in the induction of nerve damage in leprosy using two different protocols for obtaining graded levels of T-cell depletion (i) Cyclosporine A, for depletion of T-helper cells and (ii) Anti Thy 1.2, for total depletion of T-cells. The findings indicate that the early changes seen in the unmyelinated fibres may not involve T-cells. However, the later stages of nerve damage associated with demyelination are dependent on T-cell responses.
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Theme:
Complicacoes
/
Etiologia
/
Geral
/
Tratamento_medicamentoso
Database:
MEDLINE
Main subject:
Sciatic Nerve
/
T-Lymphocytes
/
Leprosy
/
Mycobacterium leprae
Type of study:
Etiology_studies
Language:
En
Journal:
Indian J Lepr
Year:
1995
Document type:
Article