Immunoglobulin G response against 10-kDa and 65-kDa heat-shock proteins in leprosy patients and their household contacts.
FEMS Immunol Med Microbiol
; 15(4): 189-98, 1996 Oct.
Article
in En
| MEDLINE
| ID: mdl-8908480
ABSTRACT
We measured antibody responses to recombinant Mycobacterium leprae 65-kDa (rML65) and 10-kDa (rML10) by indirect ELISA in sera from leprosy patients, household contacts and healthy controls in a leprosy-endemic area in the north east of Argentina. Serum antibody levels to those antigens were correlated with IgM anti-phenolic glycolipid I (PGL-I) levels, with bacterial index and the period of time under chemotherapy. Bacterial index positive (BI+) patients showed higher mean values when compared with BI negatives (BI-). Among lepromatous patients a positive correlation was observed between IgG antibody responses to both recombinant antigens and IgM antibody response to PGL-I. Anti-rML10 test detected a higher percentage of positives/total than anti-rML65 in all leprosy groups and healthy contacts. Bacterial load, leprosy clinical form and the time under chemotherapy were factors which could influence levels of the antibody response. The contribution of these antibody studies for a precise and early diagnosis in leprosy is discussed.
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Theme:
Complicacoes
/
Epidemiologia
/
Geral
/
Prevencao_controle
/
Transmissao
/
Tratamento_medicamentoso
Database:
MEDLINE
Main subject:
Bacterial Proteins
/
Recombinant Proteins
/
Immunoglobulin G
/
Chaperonins
/
Chaperonin 10
/
Leprosy
/
Antibodies, Bacterial
/
Mycobacterium leprae
/
Antigens, Bacterial
Type of study:
Diagnostic_studies
/
Screening_studies
Country/Region as subject:
America do sul
/
Argentina
Language:
En
Journal:
FEMS Immunol Med Microbiol
Year:
1996
Document type:
Article