On the origin of leprosy
s.l; s.n; 2005. 3 p. tab, graf, mapas.
No convencional
en Inglés
| Sec. Est. Saúde SP, HANSEN, Hanseníase, SESSP-ILSLPROD, Sec. Est. Saúde SP, SESSP-ILSLACERVO, Sec. Est. Saúde SP
| ID: biblio-1097746
Biblioteca responsable:
BR191.1
Ubicación: BR191.1
ABSTRACT
Leprosy, a chronic human disease with potentially debilitating neurological consequences, results from infection with Mycobacterium leprae. This unculturable pathogen has undergone extensive reductive evolution, with half of its genome now occupied by pseudogenes. Using comparative genomics, we demonstrated that all extant cases of leprosy are attributable to a single clone whose dissemination worldwide can be retraced from analysis of very rare single-nucleotide polymorphisms. The disease seems to have originated in Eastern Africa or the Near East and spread with successive human migrations. Europeans or North Africans introduced leprosy into West Africa and the Americas within the past 500 years.
Tema:
Complicaciones
/
Epidemiologia
/
Etiología
/
Geral
/
Historia
/
Transmisión
Bases de datos:
HANSEN
/
HANSENIASE
/
Sec. Est. Saúde SP
Asunto principal:
Asia
/
Américas
/
Seudogenes
/
Genoma Bacteriano
/
Análisis de Secuencia por Matrices de Oligonucleótidos
/
Polimorfismo de Nucleótido Simple
/
África
/
Emigración e Inmigración
/
Europa (Continente)
/
Genes Bacterianos
País/Región como asunto:
Africa
/
Asia
/
Europa
Idioma:
Inglés
Año de publicación:
2005
Tipo del documento:
No convencional
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