T-cell response to my mycobacterial antigens in lepromatous and tuberculoid leprosy
Mem. Inst. Oswaldo Cruz
; 82(supl.2): 153-157, 1987. tab
Article
en En
| LILACS
| ID: lil-623777
Biblioteca responsable:
BR1.1
ABSTRACT
We showed that a large fraction of lepromatous patients do harbor helper-type circulating T-cells that can be activated in vitro by Mycobacterium leprae. M. leprae and PPD triggered T-cell lines could be then obtained from both tuberculoid and lepromatous patients. The proliferative response of these helper T-cells is predominantly directed against epitopes shared by several species of mycobacteria, in lepromatous patients as well as in tuberculoid patients, but species specific T-cells are also present. When presented in the context of M. leprae, these cross reactive epitopes usually fail to stimulate the T-cell lines of lepromatous patients, because of the contamination of the lines by supressor T-cells actavable by M. leprae. In one lepromatous patient, PPD and M. leprae reactive T-cell lines and clones (of the CD4 phenotype), exhibited a strong cytotoxic activity to autologous target cells coated with antigen the relevance of this phenomenon to the pathophysiology of lepromatous leprosy remains however unknown.
Texto completo:
1
Tema:
Geral
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Prevencao_controle
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Transmissao
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Tratamento_medicamentoso
Bases de datos:
LILACS
Asunto principal:
Linfocitos T
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Lepra Tuberculoide
Idioma:
En
Revista:
Mem. Inst. Oswaldo Cruz
Año:
1987
Tipo del documento:
Article
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Congress and conference