Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones.
Science
; 254(5029): 279-82, 1991 Oct 11.
Article
en En
| MEDLINE
| ID: mdl-1681588
ABSTRACT
Functional subsets of human T cells were delineated by analyzing patterns of lymphokines produced by clones from individuals with leprosy and by T cell clones of known function. CD4 clones from individuals with strong cell-mediated immunity produced predominantly interferon-gamma, whereas those clones that enhanced antibody formation produced interleukin-4. CD8 cytotoxic T cells secreted interferon-gamma. Interleukin-4 was produced by CD8 T suppressor clones from immunologically unresponsive individuals with leprosy and was found to be necessary for suppression in vitro. Both the classic reciprocal relation between antibody formation and cell-mediated immunity and resistance or susceptibility to certain infections may be explained by T cell subsets differing in patterns of lymphokine production.
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Tema:
Complicacoes
/
Geral
/
Transmissao
/
Tratamento_medicamentoso
Bases de datos:
MEDLINE
Asunto principal:
Antígenos CD4
/
Subgrupos de Linfocitos T
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Linfocinas
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Antígenos CD8
Idioma:
En
Revista:
Science
Año:
1991
Tipo del documento:
Article