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Rifampicin and clarithromycin (extended release) versus rifampicin and streptomycin for limited Buruli ulcer lesions: a randomised, open-label, non-inferiority phase 3 trial.
Phillips, Richard O; Robert, Jérôme; Abass, Kabiru Mohamed; Thompson, William; Sarfo, Fred Stephen; Wilson, Tuah; Sarpong, Godfred; Gateau, Thierry; Chauty, Annick; Omollo, Raymond; Ochieng Otieno, Michael; Egondi, Thaddaeus W; Ampadu, Edwin O; Agossadou, Didier; Marion, Estelle; Ganlonon, Line; Wansbrough-Jones, Mark; Grosset, Jacques; Macdonald, John M; Treadwell, Terry; Saunderson, Paul; Paintsil, Albert; Lehman, Linda; Frimpong, Michael; Sarpong, Nanaa Francisca; Saizonou, Raoul; Tiendrebeogo, Alexandre; Ohene, Sally-Ann; Stienstra, Ymkje; Asiedu, Kingsley B; van der Werf, Tjip S.
Afiliación
  • Phillips RO; Kwame Nkrumah University of Science and Technology, Kumasi Centre for Collaborative Research in Tropical Medicine, Komfo Anokye Teaching Hospital, Kumasi, Ghana.
  • Robert J; Centre d'immunologie et des maladies infectieuses, Inserm, Sorbonne Université, Bactériologie site Pitié, AP-HP Sorbonne Université, Centre National de Référence des Mycobactéries, Paris, France.
  • Abass KM; Agogo Presbyterian Hospital, Agogo, Ghana.
  • Thompson W; Agogo Presbyterian Hospital, Agogo, Ghana.
  • Sarfo FS; Kwame Nkrumah University of Science and Technology, Kumasi Centre for Collaborative Research in Tropical Medicine, Komfo Anokye Teaching Hospital, Kumasi, Ghana.
  • Wilson T; Nkawie-Toaso Government Hospital, Ghana.
  • Sarpong G; Dunkwa Government Hospital, Dunkwa-on-Offin, Ghana.
  • Gateau T; Centre de diagnostic et de traitement de la lèpre et de l'Ulcère de Buruli Madeleine et Raoul Follereau, Ouémé-Plateau, Pobè, Bénin.
  • Chauty A; Centre de diagnostic et de traitement de la lèpre et de l'Ulcère de Buruli Madeleine et Raoul Follereau, Ouémé-Plateau, Pobè, Bénin.
  • Omollo R; Drugs for Neglected Diseases initiative, Africa Regional Office, Nairobi, Kenya.
  • Ochieng Otieno M; Drugs for Neglected Diseases initiative, Africa Regional Office, Nairobi, Kenya.
  • Egondi TW; Drugs for Neglected Diseases initiative, Africa Regional Office, Nairobi, Kenya.
  • Ampadu EO; National Buruli ulcer Control Programme, Ghana Health Service, Accra, Ghana.
  • Agossadou D; Programme National de Lutte contre la lèpre et l'Ulcère de Buruli, Cotonou, Benin.
  • Marion E; Centre de recherche en cancérologie et immunologie Nantes-Angers, French National Institute of Health and Medical Research, Université d'Angers, Angers, France.
  • Ganlonon L; Centre de diagnostic et de traitement de la lèpre et de l'Ulcère de Buruli Madeleine et Raoul Follereau, Ouémé-Plateau, Pobè, Bénin.
  • Wansbrough-Jones M; Institute of Infection and Immunity, St George's University of London, London, UK.
  • Grosset J; Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.
  • Macdonald JM; Department of Dermatology & Cutaneous Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA; Hospital Bernard Meys Project Medishare, Port-au-Prince, Haiti.
  • Treadwell T; Institute for Advanced Wound Care, Montgomery, AL, USA.
  • Saunderson P; American Leprosy Missions, Greenville, SC, USA.
  • Paintsil A; Reconstructive and Plastic Surgery Unit, Korle-BU Teaching Hospital, Accra, Ghana.
  • Lehman L; American Leprosy Missions, Greenville, SC, USA.
  • Frimpong M; Kwame Nkrumah University of Science and Technology, Kumasi Centre for Collaborative Research in Tropical Medicine, Komfo Anokye Teaching Hospital, Kumasi, Ghana.
  • Sarpong NF; Kwame Nkrumah University of Science and Technology, Kumasi Centre for Collaborative Research in Tropical Medicine, Komfo Anokye Teaching Hospital, Kumasi, Ghana.
  • Saizonou R; WHO, Country Office for Benin, Cotonou, Benin.
  • Tiendrebeogo A; WHO, Regional Office for Africa, Brazzaville, Republic of the Congo.
  • Ohene SA; WHO, Country Office for Ghana, Accra, Ghana.
  • Stienstra Y; Department of Medicine/Infectious Diseases, University of Groningen, University Medical Centre Groningen, Groningen, Netherlands.
  • Asiedu KB; Department of Neglected Tropical Diseases, WHO, Geneva, Switzerland.
  • van der Werf TS; Department of Medicine/Infectious Diseases, University of Groningen, University Medical Centre Groningen, Groningen, Netherlands. Electronic address: t.s.van.der.werf@umcg.nl.
Lancet ; 395(10232): 1259-1267, 2020 04 18.
Article en En | MEDLINE | ID: mdl-32171422
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Texto completo: 1 Tema: Complicacoes / Geral / Tratamento_medicamentoso Bases de datos: MEDLINE Asunto principal: Rifampin / Estreptomicina / Claritromicina / Úlcera de Buruli Tipo de estudio: Clinical_trials País/Región como asunto: Africa Idioma: En Revista: Lancet Año: 2020 Tipo del documento: Article
Texto completo
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Texto completo: 1 Tema: Complicacoes / Geral / Tratamento_medicamentoso Bases de datos: MEDLINE Asunto principal: Rifampin / Estreptomicina / Claritromicina / Úlcera de Buruli Tipo de estudio: Clinical_trials País/Región como asunto: Africa Idioma: En Revista: Lancet Año: 2020 Tipo del documento: Article