Adverse events in patients with leprosy on treatment with thalidomide
Rev. Soc. Bras. Med. Trop
; 52: e20180385, 2019. tab
Artigo
em Inglês
| LILACS
| ID: biblio-1041594
Biblioteca responsável:
BR1.1
ABSTRACT
Abstract INTRODUCTION:
Thalidomide, used to treat erythema nodosum leprosum (ENL), is associated with severe adverse events (AEs) and is highly teratogenic.METHODS:
A cross-sectional study was conducted on thalidomide-treated patients with ENL. AEs and selected variables were investigated through interviews and assessment of medical records. Odds ratios with 95% confidence intervals were estimated via logistic regression.RESULTS:
Peripheral neuropathy symptoms and deep vein thrombosis (DVT) were the most common AEs reported. Although women of reproductive age used contraceptives, <50% of patients reported using condoms. Polypharmacy was associated with all endpoints, except DVT.CONCLUSIONS:
Pharmacovigilance is crucial to prevent harmful thalidomide-associated AEs.
Texto completo:
Disponível
Tema:
Complicações
/
Epidemiologia
/
Geral
/
Tratamento Medicamentoso
Bases de dados:
LILACS
Assunto principal:
Talidomida
/
Hansenostáticos
/
Hanseníase
Tipo de estudo:
Estudo observacional
/
Estudo de prevalência
/
Fatores de risco
Idioma:
Inglês
Revista:
Rev. Soc. Bras. Med. Trop
Ano de publicação:
2019
Tipo de documento:
Artigo
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