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Association of MICA and HLA­B alleles with leprosy in two endemic populations in Brazil
s.l; s.n; 2021. 10 p.
Não convencional em Inglês | HANSEN, SES-SP, CONASS, HANSENIASE, SESSP-ILSLPROD, SES-SP, SESSP-ILSLACERVO, SES-SP | ID: biblio-1146801
Biblioteca responsável: BR191.1
Localização: BR191.1; 9786
ABSTRACT
Leprosy is a prevalent disease in Brazil, which ranks as the country with the second highest number of cases in the world. The disease manifests in a spectrum of forms, and genetic differences in the host can help to elucidate the immunopathogenesis. For a better understanding of MICA association with leprosy, we performed a case­control and a family­based study in two endemic populations in Brazil. MICA and HLA­B alleles were evaluated in 409 leprosy patients and in 419 healthy contacts by PCR­SSOP­Luminex­based technology. In the familial study, analysis of 46 families was completed by direct sequencing of all exons and 3'/5'untranslated regions, using the Ilumina MiSeq platform. All data were collected between 2006 and 2009. Statistical analysis was performed using the Chi­square or Fisher's exact test together with a multivariate analysis. Family­based association was assessed by transmission disequilibrium test (TDT) software FBAT 2.0.4. We found associations between the haplotype MICA*002­HLA­B*35 with leprosy in both the per se and the multibacillary (MB) forms when compared to healthy contacts. The MICA allele *008 was associated with the clinical forms of paucibacillary (PB). Additionally, MICA*029 was associated with the clinical forms of MB. The association of MICA*029 allele (MICA­A4 variant) with the susceptibility to the MB form suggests this variant for the transmembrane domain of the MICA molecule may be a risk factor for leprosy. Two MICA and nine HLA­B variants were found associated with leprosy per se in the Colônia do Prata population. Linkage disequilibrium analysis revealed perfect linkage disequilibrium (LD) between HLA­B markers rs2596498 and rs2507992, and high LD (R2 = .92) between these and the marker rs2442718. This familial study demonstrates that MICA association signals are not independent from those observed for HLA­B. Our findings contribute the knowledge pool of the immunogenetics of Hansen's disease and reveals a new association of the MICA*029 allele(AU).
Assuntos


Tema: Complicações / Etiologia / Geral / Transmissão Bases de dados: HANSEN / HANSENIASE / Sec. Est. Saúde SP Assunto principal: Antígenos de Histocompatibilidade Classe I / Antígenos HLA-B / Hanseníase Tipo de estudo: Ensaio clínico controlado / Estudo de etiologia / Fatores de risco País/Região como assunto: America do sul / Brasil Idioma: Inglês Ano de publicação: 2021 Tipo de documento: Não convencional

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Tema: Complicações / Etiologia / Geral / Transmissão Bases de dados: HANSEN / HANSENIASE / Sec. Est. Saúde SP Assunto principal: Antígenos de Histocompatibilidade Classe I / Antígenos HLA-B / Hanseníase Tipo de estudo: Ensaio clínico controlado / Estudo de etiologia / Fatores de risco País/Região como assunto: America do sul / Brasil Idioma: Inglês Ano de publicação: 2021 Tipo de documento: Não convencional