Clinical evaluation of isonicotinic acid hydrazide as an adjuvant in the treatment of lepromatous leprosy with a note on the detrimental effect of erythema nodosum leprosum reactions

ABSTRACT

A controlled study carried out over a period of two years of the effects of sulfones alone, of isoniazid plus sulfone, of isoniazid plus dihydro streptomycin plus PAS, and a pilot study od streptohydrazid, is reported. Flaws in the method of statistical evaluation are pointed out. The significance of erythema nodosum leprosum is investigated, and the necessity of controlling the reaction is stressed.