Enhancement of human T cell response to a peptide epitope of 38kDa antigen of Mycobacterium tuberculosis by liposomes
s.l; s.n; 2002. 9 p. graf.
Não convencional
em Inglês
| SES-SP, HANSEN, HANSENIASE, SESSP-ILSLACERVO, SES-SP
| ID: biblio-1240981
Biblioteca responsável:
BR191.1
Localização: [{"text": "BR191.1", "_a": "09061/s"}]
ABSTRACT
Diagnosis of tuberculosis a problem, specially in the regions harboring an abundance of both pathogenic and non-pathogenic mycobacteria. This study was undertaken to assess in such a situation the predictive value of proliferative T cell response to a peptide epitope ('38G') of the 38 kDa membrane protein of Mycobacterium tuberculosis. 3[H]-thymidine incorporation assays were done with peripheral blood mononuclear cells of tuberculoid leprosy and pulmonary tuberculosis patients. The donors were also classified as PPD responders (Stimulation Index, SI> 3) or non-responders (SI 3 in 54 per cent subjects) and non-responders (SI > 3 in 29 per cent subjects). However, it did not differentiate between leprosy and tuberculosis. The study supports use of liposomes as adjuvant vehicles for antigenic peptides designed to activate human T cells.
Tema:
Geral
/
Tratamento Medicamentoso
Bases de dados:
HANSEN
/
HANSENIASE
/
Sec. Est. Saúde SP
Assunto principal:
Tuberculose Pulmonar
/
Teste Tuberculínico
/
Dados de Sequência Molecular
/
Ativação Linfocitária
/
Linfócitos T
/
Hanseníase Tuberculoide
/
Sequência de Aminoácidos
/
Diagnóstico Diferencial
/
Mycobacterium tuberculosis
/
Epitopos
Tipo de estudo:
Estudo diagnóstico
/
Estudo prognóstico
Idioma:
Inglês
Ano de publicação:
2002
Tipo de documento:
Não convencional
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