T regulatory cells (TREG)(TCD4+CD25+FOXP3+) distribution in the different clinical forms of leprosy and reactional states
An. bras. dermatol
; 90(1): 41-47, Jan-Feb/2015. tab, graf
Article
em En
| LILACS
| ID: lil-735739
Biblioteca responsável:
BR1.1
ABSTRACT
BACKGROUND:
Leprosy is characterized histologically by a spectrum of different granulomatous skin lesions, reflecting patients' immune responses to Mycobacterium leprae. Although CD4+CD25+ FoxP3+ T regulatory cells are pivotal in the immuneregulation, presence, frequency, and distribution of Tregs in leprosy, its reactional states have been investigated in few studies.OBJECTIVES:
This study aimed to verify the frequency and distribution of regulatory T cells in different clinical forms and reactional states of leprosy.METHODS:
We performed an immunohistochemical study on 96 leprosy cases [Indeterminate (I) 9 patients; tuberculoid tuberculoid 13 patients; borderline tuberculoid 26 patients; borderline borderline 3 patients; borderline lepromatous 8 patients; lepromatous lepromatous 27 patients; reversal reaction 8 patients; and erythema nodosum leprosum 2 patients].RESULTS:
FoxP3-positive cells were present in 100% of the cases with an average density of 2.82% of the infiltrate. Their distribution was not related to granulomatous structures or special locations. There was a statistically significant increment of FoxP3 expression in patients with leprosy reversal reactions when compared with patients presenting with type I leprosy (P= 0.0228); borderline tuberculoid leprosy (P = 0.0351) and lepromatous leprosy (P = 0.0344).CONCLUSIONS:
These findings suggest that Tregs play a relevant role in the etiopathogenesis of leprosy, mainly in type I leprosy reaction. .Palavras-chave
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Tema:
Complicacoes
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Geral
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Tratamento_medicamentoso
Bases de dados:
LILACS
Assunto principal:
Linfócitos T Reguladores
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Granuloma
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Hanseníase
Tipo de estudo:
Observational_studies
Idioma:
En
Revista:
An. bras. dermatol
Ano de publicação:
2015
Tipo de documento:
Article