Structure-activity relationships of selected phenazines against Mycobacterium leprae in vitro.
Antimicrob Agents Chemother
; 32(10): 1583-5, 1988 Oct.
Article
em En
| MEDLINE
| ID: mdl-3056241
ABSTRACT
Structure-activity relationships of phenazines against Mycobacterium leprae were investigated by using an in vitro radiorespirometric assay. In general, activity in ascending order was observed in compounds containing no chlorine atoms, a monochlorinated phenazine nucleus, and chlorines in the para positions of both the anilino and phenyl rings. The most active compounds contained a 2,2,6,6-tetramethylpiperidine substitution at the imino nitrogen. Most of these chlorinated phenazines were considerably more active in vitro than clofazimine (B663).
Texto completo:
1
Tema:
Geral
/
Transmissao
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Tratamento_medicamentoso
Bases de dados:
MEDLINE
Assunto principal:
Fenazinas
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Hansenostáticos
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Mycobacterium leprae
Idioma:
En
Revista:
Antimicrob Agents Chemother
Ano de publicação:
1988
Tipo de documento:
Article