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1.
Functional screening of lysosomal storage disorder genes identifies modifiers of alpha-synuclein neurotoxicity.
PLoS Genet
; 19(5): e1010760, 2023 05.
Article
in English
| MEDLINE | ID: mdl-37200393
2.
Integration of transcriptome-wide association study with neuronal dysfunction assays provides functional genomics evidence for Parkinson's disease genes.
Hum Mol Genet
; 32(4): 685-695, 2023 01 27.
Article
in English
| MEDLINE | ID: mdl-36173927
3.
Dual targeting of brain region-specific kinases potentiates neurological rescue in Spinocerebellar ataxia type 1.
EMBO J
; 40(7): e106106, 2021 04 01.
Article
in English
| MEDLINE | ID: mdl-33709453
4.
TMEM106B coding variant is protective and deletion detrimental in a mouse model of tauopathy.
Acta Neuropathol
; 147(1): 61, 2024 Mar 25.
Article
in English
| MEDLINE | ID: mdl-38526616
5.
Spinocerebellar Ataxia Type 1 protein Ataxin-1 is signaled to DNA damage by ataxia-telangiectasia mutated kinase.
Hum Mol Genet
; 30(8): 706-715, 2021 05 17.
Article
in English
| MEDLINE | ID: mdl-33772540
6.
Cross-species genetic screens to identify kinase targets for APP reduction in Alzheimer's disease.
Hum Mol Genet
; 28(12): 2014-2029, 2019 06 15.
Article
in English
| MEDLINE | ID: mdl-30753434
7.
Harnessing the paradoxical phenotypes of APOE É2 and APOE É4 to identify genetic modifiers in Alzheimer's disease.
Alzheimers Dement
; 17(5): 831-846, 2021 05.
Article
in English
| MEDLINE | ID: mdl-33576571
8.
A Druggable Genome Screen Identifies Modifiers of α-Synuclein Levels via a Tiered Cross-Species Validation Approach.
J Neurosci
; 38(43): 9286-9301, 2018 10 24.
Article
in English
| MEDLINE | ID: mdl-30249792
9.
Huntingtin proteolysis releases non-polyQ fragments that cause toxicity through dynamin 1 dysregulation.
EMBO J
; 34(17): 2255-71, 2015 Sep 02.
Article
in English
| MEDLINE | ID: mdl-26165689
10.
RAS-MAPK-MSK1 pathway modulates ataxin 1 protein levels and toxicity in SCA1.
Nature
; 498(7454): 325-331, 2013 Jun 20.
Article
in English
| MEDLINE | ID: mdl-23719381
11.
Smaug/SAMD4A restores translational activity of CUGBP1 and suppresses CUG-induced myopathy.
PLoS Genet
; 9(4): e1003445, 2013 Apr.
Article
in English
| MEDLINE | ID: mdl-23637619
12.
A genome-scale RNA-interference screen identifies RRAS signaling as a pathologic feature of Huntington's disease.
PLoS Genet
; 8(11): e1003042, 2012.
Article
in English
| MEDLINE | ID: mdl-23209424
13.
Inhibition of lipid signaling enzyme diacylglycerol kinase epsilon attenuates mutant huntingtin toxicity.
J Biol Chem
; 287(25): 21204-13, 2012 Jun 15.
Article
in English
| MEDLINE | ID: mdl-22511757
14.
Evolutionarily conserved regulators of tau identify targets for new therapies.
Neuron
; 111(6): 824-838.e7, 2023 03 15.
Article
in English
| MEDLINE | ID: mdl-36610398
15.
SPA-STOCSY: An Automated Tool for Identification of Annotated and Non-Annotated Metabolites in High-Throughput NMR Spectra.
bioRxiv
; 2023 Feb 22.
Article
in English
| MEDLINE | ID: mdl-36865102
16.
TMEM106B coding variant is protective and deletion detrimental in a mouse model of tauopathy.
bioRxiv
; 2023 Mar 25.
Article
in English
| MEDLINE | ID: mdl-36993574
17.
Functional variants identify sex-specific genes and pathways in Alzheimer's Disease.
Nat Commun
; 14(1): 2765, 2023 05 13.
Article
in English
| MEDLINE | ID: mdl-37179358
18.
Tau polarizes an aging transcriptional signature to excitatory neurons and glia.
Elife
; 122023 May 23.
Article
in English
| MEDLINE | ID: mdl-37219079
19.
Upregulation of the ESCRT pathway and multivesicular bodies accelerates degradation of proteins associated with neurodegeneration.
Autophagy Rep
; 2(1)2023.
Article
in English
| MEDLINE | ID: mdl-37064812
20.
Identification of risk genes for Alzheimer's disease by gene embedding.
Cell Genom
; 2(9)2022 Sep 14.
Article
in English
| MEDLINE | ID: mdl-36268052