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1.
Mild Condition for the Deoxygenation of α-Heteroaryl-Substituted Methanol Derivatives.
J Org Chem
; 86(8): 5560-5567, 2021 Apr 16.
Article
in English
| MEDLINE | ID: mdl-33784101
2.
Cholesteryl ester transfer protein (CETP) inhibitors based on cyclic urea, bicyclic urea and bicyclic sulfamide cores.
Bioorg Med Chem Lett
; 32: 127668, 2021 01 15.
Article
in English
| MEDLINE | ID: mdl-33161125
3.
Pharmacological Characterization of the Novel and Selective α7 Nicotinic Acetylcholine Receptor-Positive Allosteric Modulator BNC375.
J Pharmacol Exp Ther
; 373(2): 311-324, 2020 05.
Article
in English
| MEDLINE | ID: mdl-32094294
4.
MK-8719, a Novel and Selective O-GlcNAcase Inhibitor That Reduces the Formation of Pathological Tau and Ameliorates Neurodegeneration in a Mouse Model of Tauopathy.
J Pharmacol Exp Ther
; 374(2): 252-263, 2020 08.
Article
in English
| MEDLINE | ID: mdl-32493725
5.
Selective N7 Alkylation of 7-Azaindazoles.
J Org Chem
; 85(11): 7558-7564, 2020 06 05.
Article
in English
| MEDLINE | ID: mdl-32362114
6.
Discovery of ethyl ketone-based HDACs 1, 2, and 3 selective inhibitors for HIV latency reactivation.
Bioorg Med Chem Lett
; 30(13): 127197, 2020 07 01.
Article
in English
| MEDLINE | ID: mdl-32331932
7.
Development of a selective HDAC inhibitor aimed at reactivating the HIV latent reservoir.
Bioorg Med Chem Lett
; 30(17): 127367, 2020 09 01.
Article
in English
| MEDLINE | ID: mdl-32738976
8.
Potent, non-covalent reversible BTK inhibitors with 8-amino-imidazo[1,5-a]pyrazine core featuring 3-position bicyclic ring substitutes.
Bioorg Med Chem Lett
; 30(17): 127390, 2020 09 01.
Article
in English
| MEDLINE | ID: mdl-32738973
9.
A novel benzazepinone sodium channel blocker with oral efficacy in a rat model of neuropathic pain.
Bioorg Med Chem Lett
; 23(12): 3640-5, 2013 Jun 15.
Article
in English
| MEDLINE | ID: mdl-23652221
10.
Characterization of the substituted N-triazole oxindole TROX-1, a small-molecule, state-dependent inhibitor of Ca(V)2 calcium channels.
Mol Pharmacol
; 81(3): 488-97, 2012 Mar.
Article
in English
| MEDLINE | ID: mdl-22188924
11.
A potent and selective indole N-type calcium channel (Ca(v)2.2) blocker for the treatment of pain.
Bioorg Med Chem Lett
; 21(2): 869-73, 2011 Jan 15.
Article
in English
| MEDLINE | ID: mdl-21195616
12.
Discovery of Ethyl Ketone-Based Highly Selective HDACs 1, 2, 3 Inhibitors for HIV Latency Reactivation with Minimum Cellular Potency Serum Shift and Reduced hERG Activity.
J Med Chem
; 64(8): 4709-4729, 2021 04 22.
Article
in English
| MEDLINE | ID: mdl-33797924
13.
Invention of MK-8262, a Cholesteryl Ester Transfer Protein (CETP) Inhibitor Backup to Anacetrapib with Best-in-Class Properties.
J Med Chem
; 64(18): 13215-13258, 2021 09 23.
Article
in English
| MEDLINE | ID: mdl-34375108
14.
Analgesic effects of a substituted N-triazole oxindole (TROX-1), a state-dependent, voltage-gated calcium channel 2 blocker.
J Pharmacol Exp Ther
; 334(2): 545-55, 2010 Aug.
Article
in English
| MEDLINE | ID: mdl-20439438
15.
Discovery of a novel class of biphenyl pyrazole sodium channel blockers for treatment of neuropathic pain.
Bioorg Med Chem Lett
; 20(24): 7479-82, 2010 Dec 15.
Article
in English
| MEDLINE | ID: mdl-21106456
16.
Discovery of Highly Selective and Potent HDAC3 Inhibitors Based on a 2-Substituted Benzamide Zinc Binding Group.
ACS Med Chem Lett
; 11(12): 2476-2483, 2020 Dec 10.
Article
in English
| MEDLINE | ID: mdl-33335670
17.
Selective Class I HDAC Inhibitors Based on Aryl Ketone Zinc Binding Induce HIV-1 Protein for Clearance.
ACS Med Chem Lett
; 11(7): 1476-1483, 2020 Jul 09.
Article
in English
| MEDLINE | ID: mdl-32676157
18.
Discovery of MK-8719, a Potent O-GlcNAcase Inhibitor as a Potential Treatment for Tauopathies.
J Med Chem
; 62(22): 10062-10097, 2019 11 27.
Article
in English
| MEDLINE | ID: mdl-31487175
19.
Imidazopyridines: a novel class of hNav1.7 channel blockers.
Bioorg Med Chem Lett
; 18(5): 1696-701, 2008 Mar 01.
Article
in English
| MEDLINE | ID: mdl-18243692
20.
Discovery of imidazole carboxamides as potent and selective CCK1R agonists.
Bioorg Med Chem Lett
; 18(15): 4393-6, 2008 Aug 01.
Article
in English
| MEDLINE | ID: mdl-18614364