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1.
First-in-man study to investigate safety, pharmacokinetics and exploratory pharmacodynamics of HTL0018318, a novel M1 -receptor partial agonist for the treatment of dementias.
Br J Clin Pharmacol
; 87(7): 2945-2955, 2021 07.
Article
in English
| MEDLINE | ID: mdl-33351971
2.
Safety, pharmacokinetics and pharmacodynamics of HTL0009936, a selective muscarinic M1 -acetylcholine receptor agonist: A randomized cross-over trial.
Br J Clin Pharmacol
; 87(11): 4439-4449, 2021 11.
Article
in English
| MEDLINE | ID: mdl-33891333
3.
Safety, pharmacokinetics and pharmacodynamics of SBT-020 in patients with early stage Huntington's disease, a 2-part study.
Br J Clin Pharmacol
; 87(5): 2290-2302, 2021 05.
Article
in English
| MEDLINE | ID: mdl-33197078
4.
Reversal of mecamylamine-induced effects in healthy subjects by nicotine receptor agonists: Cognitive and (electro) physiological responses.
Br J Clin Pharmacol
; 84(5): 888-899, 2018 05.
Article
in English
| MEDLINE | ID: mdl-29319910
5.
Cognitive Performance and Apathy Predict Unemployment in Huntington's Disease Mutation Carriers.
J Neuropsychiatry Clin Neurosci
; 30(3): 188-193, 2018.
Article
in English
| MEDLINE | ID: mdl-29325477
6.
Longitudinal resting state fMRI analysis in healthy controls and premanifest Huntington's disease gene carriers: a three-year follow-up study.
Hum Brain Mapp
; 36(1): 110-9, 2015 Jan.
Article
in English
| MEDLINE | ID: mdl-25139578
7.
Reliability and factor structure of the Short Problem Behaviors Assessment for Huntington's disease (PBA-s) in the TRACK-HD and REGISTRY studies.
J Neuropsychiatry Clin Neurosci
; 27(1): 59-64, 2015.
Article
in English
| MEDLINE | ID: mdl-25716488
8.
Motor dysfunction influence on executive functioning in manifest and premanifest Huntington's disease.
Mov Disord
; 29(3): 320-6, 2014 Mar.
Article
in English
| MEDLINE | ID: mdl-24500841
9.
Better global and cognitive functioning in choreatic versus hypokinetic-rigid Huntington's disease.
Mov Disord
; 28(8): 1142-5, 2013 Jul.
Article
in English
| MEDLINE | ID: mdl-23495076
10.
Elevated brain iron is independent from atrophy in Huntington's Disease.
Neuroimage
; 61(3): 558-64, 2012 Jul 02.
Article
in English
| MEDLINE | ID: mdl-22480728
11.
Evaluation of longitudinal 12 and 24 month cognitive outcomes in premanifest and early Huntington's disease.
J Neurol Neurosurg Psychiatry
; 83(7): 687-94, 2012 Jul.
Article
in English
| MEDLINE | ID: mdl-22566599
12.
A cross-sectional study in healthy elderly subjects aimed at development of an algorithm to increase identification of Alzheimer pathology for the purpose of clinical trial participation.
Alzheimers Res Ther
; 13(1): 132, 2021 07 17.
Article
in English
| MEDLINE | ID: mdl-34274005
13.
Safety, pharmacokinetics and exploratory pro-cognitive effects of HTL0018318, a selective M1 receptor agonist, in healthy younger adult and elderly subjects: a multiple ascending dose study.
Alzheimers Res Ther
; 13(1): 87, 2021 04 21.
Article
in English
| MEDLINE | ID: mdl-33883008
14.
Safety, pharmacokinetics, and pharmacodynamics of Gln-1062, a prodrug of galantamine.
Alzheimers Dement (N Y)
; 6(1): e12093, 2020.
Article
in English
| MEDLINE | ID: mdl-33083515
15.
Quantification of tremor using consumer product accelerometry is feasible in patients with essential tremor and Parkinson's disease: a comparative study.
J Clin Mov Disord
; 7: 4, 2020.
Article
in English
| MEDLINE | ID: mdl-32280482
16.
Brain Bio-Energetic State Does Not Correlate to Muscle Mitochondrial Function in Huntington's Disease.
J Huntingtons Dis
; 9(4): 335-344, 2020.
Article
in English
| MEDLINE | ID: mdl-33325391
17.
Predictors of simulated driving performance in Huntington's disease.
Parkinsonism Relat Disord
; 60: 64-69, 2019 03.
Article
in English
| MEDLINE | ID: mdl-30292732
18.
A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development.
J Vis Exp
; (144)2019 02 11.
Article
in English
| MEDLINE | ID: mdl-30799845
19.
An EEG nicotinic acetylcholine index to assess the efficacy of pro-cognitive compounds.
Clin Neurophysiol
; 129(11): 2325-2332, 2018 11.
Article
in English
| MEDLINE | ID: mdl-30248622
20.
The visual cortex and visual cognition in Huntington's disease: An overview of current literature.
Behav Brain Res
; 351: 63-74, 2018 10 01.
Article
in English
| MEDLINE | ID: mdl-29792890