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1.
Non-specific binding of compounds in in vitro metabolism assays: a comparison of microsomal and hepatocyte binding in different species and an assessment of the accuracy of prediction models.
Xenobiotica
; 52(8): 943-956, 2022 Aug.
Article
in English
| MEDLINE | ID: mdl-36222269
2.
Nano-LC: An updated review.
Biomed Chromatogr
; 36(5): e5317, 2022 May.
Article
in English
| MEDLINE | ID: mdl-34981550
3.
Impact of Interindividual Differences in Plasma Fraction Unbound on the Pharmacokinetics of a Novel Syk Kinase Inhibitor in Beagle Dogs.
Drug Metab Dispos
; 49(9): 736-742, 2021 09.
Article
in English
| MEDLINE | ID: mdl-34135088
4.
Considerations from the Innovation and Quality Induction Working Group in Response to Drug-Drug Interaction Guidance from Regulatory Agencies: Guidelines on Model Fitting and Recommendations on Time Course for In Vitro Cytochrome P450 Induction Studies Including Impact on Drug Interaction Risk Assessment.
Drug Metab Dispos
; 49(1): 94-110, 2021 01.
Article
in English
| MEDLINE | ID: mdl-33139460
5.
Protein Biomarker Quantification by Immunoaffinity Liquid Chromatography-Tandem Mass Spectrometry: Current State and Future Vision.
Clin Chem
; 66(2): 282-301, 2020 02 01.
Article
in English
| MEDLINE | ID: mdl-32040572
6.
A Laboratory-Specific Scaling Factor to Predict the In Vivo Human Clearance of Aldehyde Oxidase Substrates.
Drug Metab Dispos
; 48(11): 1231-1238, 2020 11.
Article
in English
| MEDLINE | ID: mdl-32893186
7.
Drug metabolite identification using ultrahigh-performance liquid chromatography-ultraviolet spectroscopy and parallelized scans on a tribrid Orbitrap mass spectrometer.
Rapid Commun Mass Spectrom
; 34(10): e8735, 2020 May 30.
Article
in English
| MEDLINE | ID: mdl-31967694
8.
Cytochrome P450 2J2: Potential Role in Drug Metabolism and Cardiotoxicity.
Drug Metab Dispos
; 46(8): 1053-1065, 2018 08.
Article
in English
| MEDLINE | ID: mdl-29695613
9.
An Investigation into the Prediction of the Plasma Concentration-Time Profile and Its Interindividual Variability for a Range of Flavin-Containing Monooxygenase Substrates Using a Physiologically Based Pharmacokinetic Modeling Approach.
Drug Metab Dispos
; 46(9): 1259-1267, 2018 Sep.
Article
in English
| MEDLINE | ID: mdl-29895591
10.
Complete Substrate Inhibition of Cytochrome P450 2C8 by AZD9496, an Oral Selective Estrogen Receptor Degrader.
Drug Metab Dispos
; 46(9): 1268-1276, 2018 09.
Article
in English
| MEDLINE | ID: mdl-29921707
11.
CYP-Mediated Sulfoximine Deimination of AZD6738.
Drug Metab Dispos
; 45(11): 1133-1138, 2017 11.
Article
in English
| MEDLINE | ID: mdl-28835442
12.
Managing the Risk of CYP3A Induction in Drug Development: A Strategic Approach.
Drug Metab Dispos
; 45(1): 35-41, 2017 01.
Article
in English
| MEDLINE | ID: mdl-27777246
13.
An Investigation into the Prediction of in Vivo Clearance for a Range of Flavin-containing Monooxygenase Substrates.
Drug Metab Dispos
; 45(10): 1060-1067, 2017 10.
Article
in English
| MEDLINE | ID: mdl-28784689
14.
Considerations from the IQ Induction Working Group in Response to Drug-Drug Interaction Guidance from Regulatory Agencies: Focus on Downregulation, CYP2C Induction, and CYP2B6 Positive Control.
Drug Metab Dispos
; 45(10): 1049-1059, 2017 10.
Article
in English
| MEDLINE | ID: mdl-28646080
15.
An S-warfarin and AZD1981 interaction: in vitro and clinical pilot data suggest the N-deacetylated amino acid metabolite as the primary perpetrator.
Br J Clin Pharmacol
; 83(2): 381-392, 2017 02.
Article
in English
| MEDLINE | ID: mdl-27558866
16.
The 50th anniversary of the DMDG.
Xenobiotica
; 52(8): 767-769, 2022 08.
Article
in English
| MEDLINE | ID: mdl-36214565
17.
Time dependent analysis of assay comparability: a novel approach to understand intra- and inter-site variability over time.
J Comput Aided Mol Des
; 29(9): 795-807, 2015 Sep.
Article
in English
| MEDLINE | ID: mdl-25697964
18.
Preclinical Development of PNT6555, a Boronic Acid-Based, Fibroblast Activation Protein-α (FAP)-Targeted Radiotheranostic for Imaging and Treatment of FAP-Positive Tumors.
J Nucl Med
; 65(1): 100-108, 2024 Jan 02.
Article
in English
| MEDLINE | ID: mdl-38050111
19.
Anticancer activity of stabilized palifosfamide in vivo: schedule effects, oral bioavailability, and enhanced activity with docetaxel and doxorubicin.
Anticancer Drugs
; 23(2): 173-84, 2012 Feb.
Article
in English
| MEDLINE | ID: mdl-22027537
20.
Application of PBPK modelling in drug discovery and development at Pfizer.
Xenobiotica
; 42(1): 94-106, 2012 Jan.
Article
in English
| MEDLINE | ID: mdl-22035569