Search details
1.
Ligandability assessment of the C-terminal Rel-homology domain of NFAT1.
Arch Pharm (Weinheim)
; 357(6): e2300649, 2024 Jun.
Article
in English
| MEDLINE | ID: mdl-38396281
2.
HUWE1 employs a giant substrate-binding ring to feed and regulate its HECT E3 domain.
Nat Chem Biol
; 17(10): 1084-1092, 2021 10.
Article
in English
| MEDLINE | ID: mdl-34294896
3.
Drugging an undruggable pocket on KRAS.
Proc Natl Acad Sci U S A
; 116(32): 15823-15829, 2019 08 06.
Article
in English
| MEDLINE | ID: mdl-31332011
4.
PI by NMR: Probing CH-π Interactions in Protein-Ligand Complexes by NMR Spectroscopy.
Angew Chem Int Ed Engl
; 59(35): 14861-14868, 2020 08 24.
Article
in English
| MEDLINE | ID: mdl-32421895
5.
KRAS Binders Hidden in Nature.
Chemistry
; 25(52): 12037-12041, 2019 Sep 18.
Article
in English
| MEDLINE | ID: mdl-31231840
6.
The hanging heart: How KRAS lures its prey to the membrane.
Proc Natl Acad Sci U S A
; 117(43): 26556-26558, 2020 10 27.
Article
in English
| MEDLINE | ID: mdl-32999064
7.
Reply to Tran et al.: Dimeric KRAS protein-protein interaction stabilizers.
Proc Natl Acad Sci U S A
; 117(7): 3365-3367, 2020 02 18.
Article
in English
| MEDLINE | ID: mdl-32047042
8.
Fragment Optimization of Reversible Binding to the Switch II Pocket on KRAS Leads to a Potent, In Vivo Active KRASG12C Inhibitor.
J Med Chem
; 65(21): 14614-14629, 2022 11 10.
Article
in English
| MEDLINE | ID: mdl-36300829
9.
Targeting Son of Sevenless 1: The pacemaker of KRAS.
Curr Opin Chem Biol
; 62: 109-118, 2021 06.
Article
in English
| MEDLINE | ID: mdl-33848766
10.
Stopping the beating heart of cancer: KRAS reviewed.
Curr Opin Struct Biol
; 71: 136-147, 2021 12.
Article
in English
| MEDLINE | ID: mdl-34303932
11.
Getting a Grip on the Undrugged: Targeting ß-Catenin with Fragment-Based Methods.
ChemMedChem
; 16(9): 1420-1424, 2021 05 06.
Article
in English
| MEDLINE | ID: mdl-33275320
12.
One Atom Makes All the Difference: Getting a Foot in the Door between SOS1 and KRAS.
J Med Chem
; 64(10): 6569-6580, 2021 05 27.
Article
in English
| MEDLINE | ID: mdl-33719426
13.
BI-3406, a Potent and Selective SOS1-KRAS Interaction Inhibitor, Is Effective in KRAS-Driven Cancers through Combined MEK Inhibition.
Cancer Discov
; 11(1): 142-157, 2021 01.
Article
in English
| MEDLINE | ID: mdl-32816843
14.
Native Mass Spectrometry Can Effectively Predict PROTAC Efficacy.
ACS Cent Sci
; 6(7): 1223-1230, 2020 Jul 22.
Article
in English
| MEDLINE | ID: mdl-32724856
15.
Drugging all RAS isoforms with one pocket.
Future Med Chem
; 12(21): 1911-1923, 2020 11.
Article
in English
| MEDLINE | ID: mdl-32779487
16.
Intracellular Trapping of the Selective Phosphoglycerate Dehydrogenase (PHGDH) Inhibitor BI-4924 Disrupts Serine Biosynthesis.
J Med Chem
; 62(17): 7976-7997, 2019 09 12.
Article
in English
| MEDLINE | ID: mdl-31365252
17.
Direct NMR Probing of Hydration Shells of Protein Ligand Interfaces and Its Application to Drug Design.
J Med Chem
; 60(21): 8708-8715, 2017 11 09.
Article
in English
| MEDLINE | ID: mdl-28910100
18.
Chemically Induced Degradation of the Oncogenic Transcription Factor BCL6.
Cell Rep
; 20(12): 2860-2875, 2017 Sep 19.
Article
in English
| MEDLINE | ID: mdl-28930682
19.
Discovery of Novel Spiro[3H-indole-3,2'-pyrrolidin]-2(1H)-one Compounds as Chemically Stable and Orally Active Inhibitors of the MDM2-p53 Interaction.
J Med Chem
; 59(22): 10147-10162, 2016 11 23.
Article
in English
| MEDLINE | ID: mdl-27775892
20.
Structure-Based Design of an in Vivo Active Selective BRD9 Inhibitor.
J Med Chem
; 59(10): 4462-75, 2016 05 26.
Article
in English
| MEDLINE | ID: mdl-26914985