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1.
Determination of L-AP4-bound human mGlu8 receptor amino terminal domain structure and the molecular basis for L-AP4's group III mGlu receptor functional potency and selectivity.
Bioorg Med Chem Lett
; 28(4): 612-617, 2018 02 15.
Article
in English
| MEDLINE | ID: mdl-29402739
2.
Translational Pharmacology of the Metabotropic Glutamate 2 Receptor-Preferring Agonist LY2812223 in the Animal and Human Brain.
J Pharmacol Exp Ther
; 361(1): 190-197, 2017 04.
Article
in English
| MEDLINE | ID: mdl-28138041
3.
Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trial.
Nat Med
; 13(9): 1102-7, 2007 Sep.
Article
in English
| MEDLINE | ID: mdl-17767166
4.
Discovery of (1R,2R)-N-(4-(6-isopropylpyridin-2-yl)-3-(2-methyl-2H-indazol-5-yl)isothiazol-5-yl)-2-methylcyclopropanecarboxamide, a potent and orally efficacious mGlu5 receptor negative allosteric modulator.
Bioorg Med Chem Lett
; 23(5): 1249-52, 2013 Mar 01.
Article
in English
| MEDLINE | ID: mdl-23374867
5.
mGlu3 Metabotropic Glutamate Receptors as a Target for the Treatment of Absence Epilepsy: Preclinical and Human Genetics Data.
Curr Neuropharmacol
; 21(1): 105-118, 2023.
Article
in English
| MEDLINE | ID: mdl-35579153
6.
Study of novel selective mGlu2 agonist in the temporo-ammonic input to CA1 neurons reveals reduced mGlu2 receptor expression in a Wistar substrain with an anxiety-like phenotype.
J Neurosci
; 31(18): 6721-31, 2011 May 04.
Article
in English
| MEDLINE | ID: mdl-21543601
7.
Behavioural and biochemical responses to methamphetamine are differentially regulated by mGlu2 and mGlu3 metabotropic glutamate receptors in male mice.
Neuropharmacology
; 196: 108692, 2021 09 15.
Article
in English
| MEDLINE | ID: mdl-34217776
8.
In vitro and in vivo evidence for a lack of interaction with dopamine D2 receptors by the metabotropic glutamate 2/3 receptor agonists 1S,2S,5R,6S-2-aminobicyclo[3.1.0]hexane-2,6-bicaroxylate monohydrate (LY354740) and (-)-2-oxa-4-aminobicyclo[3.1.0] Hexane-4,6-dicarboxylic acid (LY379268).
J Pharmacol Exp Ther
; 331(3): 1126-36, 2009 Dec.
Article
in English
| MEDLINE | ID: mdl-19755662
9.
Metabotropic glutamate receptors as novel targets for anxiety and stress disorders.
Nat Rev Drug Discov
; 4(2): 131-44, 2005 Feb.
Article
in English
| MEDLINE | ID: mdl-15665858
10.
Structural Basis for ( S)-3,4-Dicarboxyphenylglycine (DCPG) As a Potent and Subtype Selective Agonist of the mGlu8 Receptor.
J Med Chem
; 61(22): 10040-10052, 2018 11 21.
Article
in English
| MEDLINE | ID: mdl-30365309
11.
Metabotropic Glutamate2 Receptors Play a Key Role in Modulating Head Twitches Induced by a Serotonergic Hallucinogen in Mice.
Front Pharmacol
; 9: 208, 2018.
Article
in English
| MEDLINE | ID: mdl-29599719
12.
Synthesis and Pharmacological Characterization of C4ß-Amide-Substituted 2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1 S,2 S,4 S,5 R,6 S)-2-Amino-4-[(3-methoxybenzoyl)amino]bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2794193), a Highly Potent and Selective mGlu3 Receptor Agonist.
J Med Chem
; 61(6): 2303-2328, 2018 03 22.
Article
in English
| MEDLINE | ID: mdl-29350927
13.
Synthesis and metabotropic glutamate receptor activity of S-oxidized variants of (-)-4-amino-2-thiabicyclo-[3.1.0]hexane-4,6-dicarboxylate: identification of potent, selective, and orally bioavailable agonists for mGlu2/3 receptors.
J Med Chem
; 50(2): 233-40, 2007 Jan 25.
Article
in English
| MEDLINE | ID: mdl-17228865
14.
In vivo pharmacological characterization of the structurally novel, potent, selective mGlu2/3 receptor agonist LY404039 in animal models of psychiatric disorders.
Psychopharmacology (Berl)
; 193(1): 121-36, 2007 Jul.
Article
in English
| MEDLINE | ID: mdl-17384937
15.
Broad spectrum efficacy with LY2969822, an oral prodrug of metabotropic glutamate 2/3 receptor agonist LY2934747, in rodent pain models.
Br J Pharmacol
; 174(9): 822-835, 2017 05.
Article
in English
| MEDLINE | ID: mdl-28177520
16.
In vitro pharmacological and rat pharmacokinetic characterization of LY3020371, a potent and selective mGlu2/3 receptor antagonist.
Neuropharmacology
; 115: 100-114, 2017 03 15.
Article
in English
| MEDLINE | ID: mdl-26748052
17.
Discovery of (1S,2R,3S,4S,5R,6R)-2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371·HCl): A Potent, Metabotropic Glutamate 2/3 Receptor Antagonist with Antidepressant-Like Activity.
J Med Chem
; 59(24): 10974-10993, 2016 12 22.
Article
in English
| MEDLINE | ID: mdl-28002967
18.
Analgesic effects of the selective group II (mGlu2/3) metabotropic glutamate receptor agonists LY379268 and LY389795 in persistent and inflammatory pain models after acute and repeated dosing.
Neuropharmacology
; 49 Suppl 1: 206-18, 2005.
Article
in English
| MEDLINE | ID: mdl-15998527
19.
Methyl substitution of 2-aminobicyclo[3.1.0]hexane 2,6-dicarboxylate (LY354740) determines functional activity at metabotropic glutamate receptors: identification of a subtype selective mGlu2 receptor agonist.
J Med Chem
; 48(10): 3605-12, 2005 May 19.
Article
in English
| MEDLINE | ID: mdl-15887967
20.
Dipeptides as effective prodrugs of the unnatural amino acid (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740), a selective group II metabotropic glutamate receptor agonist.
J Med Chem
; 48(16): 5305-20, 2005 Aug 11.
Article
in English
| MEDLINE | ID: mdl-16078848