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1.
Modulation of TARP γ8-Containing AMPA Receptors as a Novel Therapeutic Approach for Chronic Pain.
J Pharmacol Exp Ther
; 369(3): 345-363, 2019 06.
Article
in English
| MEDLINE | ID: mdl-30910921
2.
The synthesis and evaluation of triazolopyrimidines as anti-tubercular agents.
Bioorg Med Chem
; 25(15): 3922-3946, 2017 08 01.
Article
in English
| MEDLINE | ID: mdl-28576632
3.
Novel bicyclo[3.1.0]hexane analogs as antagonists of metabotropic glutamate 2/3 receptors for the treatment of depression.
Bioorg Med Chem Lett
; 26(23): 5663-5668, 2016 12 01.
Article
in English
| MEDLINE | ID: mdl-27836401
4.
GluK1 antagonists from 6-(carboxy)phenyl decahydroisoquinoline derivatives. SAR and evaluation of a prodrug strategy for oral efficacy in pain models.
Bioorg Med Chem Lett
; 23(23): 6459-62, 2013 Dec 01.
Article
in English
| MEDLINE | ID: mdl-24119554
5.
GluK1 antagonists from 6-(tetrazolyl)phenyl decahydroisoquinoline derivatives: in vitro profile and in vivo analgesic efficacy.
Bioorg Med Chem Lett
; 23(23): 6463-6, 2013 Dec 01.
Article
in English
| MEDLINE | ID: mdl-24140446
6.
Excellence in Medicinal Chemistry: Celebrating ACS Medicinal Chemistry Division (MEDI) Awards. A Call for Nominations.
ACS Med Chem Lett
; 14(6): 682-684, 2023 Jun 08.
Article
in English
| MEDLINE | ID: mdl-37312854
7.
Transmembrane AMPA receptor regulatory proteins and cornichon-2 allosterically regulate AMPA receptor antagonists and potentiators.
J Biol Chem
; 286(15): 13134-42, 2011 Apr 15.
Article
in English
| MEDLINE | ID: mdl-21343286
8.
A role for Ca2+ stores in kainate receptor-dependent synaptic facilitation and LTP at mossy fiber synapses in the hippocampus.
Neuron
; 39(2): 327-41, 2003 Jul 17.
Article
in English
| MEDLINE | ID: mdl-12873388
9.
Antagonists of GLU(K5)-containing kainate receptors prevent pilocarpine-induced limbic seizures.
Nat Neurosci
; 5(8): 796-804, 2002 Aug.
Article
in English
| MEDLINE | ID: mdl-12080343
10.
Anxiolytic-like effects through a GLUK5 kainate receptor mechanism.
Neuropharmacology
; 52(7): 1482-7, 2007 Jun.
Article
in English
| MEDLINE | ID: mdl-17418283
11.
In vitro pharmacological and rat pharmacokinetic characterization of LY3020371, a potent and selective mGlu2/3 receptor antagonist.
Neuropharmacology
; 115: 100-114, 2017 03 15.
Article
in English
| MEDLINE | ID: mdl-26748052
12.
Forebrain-selective AMPA-receptor antagonism guided by TARP γ-8 as an antiepileptic mechanism.
Nat Med
; 22(12): 1496-1501, 2016 12.
Article
in English
| MEDLINE | ID: mdl-27820603
13.
Discovery of the First α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antagonist Dependent upon Transmembrane AMPA Receptor Regulatory Protein (TARP) γ-8.
J Med Chem
; 59(10): 4753-68, 2016 05 26.
Article
in English
| MEDLINE | ID: mdl-27067148
14.
Discovery of (1S,2R,3S,4S,5R,6R)-2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371·HCl): A Potent, Metabotropic Glutamate 2/3 Receptor Antagonist with Antidepressant-Like Activity.
J Med Chem
; 59(24): 10974-10993, 2016 12 22.
Article
in English
| MEDLINE | ID: mdl-28002967
15.
Two prodrugs of potent and selective GluR5 kainate receptor antagonists actives in three animal models of pain.
J Med Chem
; 48(13): 4200-3, 2005 Jun 30.
Article
in English
| MEDLINE | ID: mdl-15974569
16.
Locomotor activity detects subunit-selective effects of agonists and decahydroisoquinoline antagonists at AMPA/kainic acid ionotropic glutamate receptors in adult rats.
Psychopharmacology (Berl)
; 179(1): 181-8, 2005 Apr.
Article
in English
| MEDLINE | ID: mdl-15821949
17.
Synthesis and structure-activity relationships of novel arylpiperazines as potent and selective agonists of the melanocortin subtype-4 receptor.
J Med Chem
; 47(3): 744-55, 2004 Jan 29.
Article
in English
| MEDLINE | ID: mdl-14736255
18.
Ethyl (3S,4aR,6S,8aR)-6-(4-ethoxycar- bonylimidazol-1-ylmethyl)decahydroiso-quinoline-3-carboxylic ester: a prodrug of a GluR5 kainate receptor antagonist active in two animal models of acute migraine.
J Med Chem
; 45(20): 4383-6, 2002 Sep 26.
Article
in English
| MEDLINE | ID: mdl-12238915
19.
Antiallodynic and antihyperalgesic effects of selective competitive GLUK5 (GluR5) ionotropic glutamate receptor antagonists in the capsaicin and carrageenan models in rats.
J Pharmacol Exp Ther
; 319(1): 396-404, 2006 Oct.
Article
in English
| MEDLINE | ID: mdl-16837561
20.
Privileged structure based ligands for melanocortin-4 receptors--aliphatic piperazine derivatives.
Bioorg Med Chem Lett
; 16(13): 3449-53, 2006 Jul 01.
Article
in English
| MEDLINE | ID: mdl-16650763