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1.
A selective nonpeptide somatostatin receptor 5 agonist effectively decreases insulin secretion in hyperinsulinism.
J Biol Chem
; 299(6): 104816, 2023 06.
Article
in English
| MEDLINE | ID: mdl-37178920
2.
Discovery of 4-(3-aminopyrrolidinyl)-3-aryl-5-(benzimidazol-2-yl)-pyridines as potent and selective SST5 agonists for the treatment of congenital hyperinsulinism.
Bioorg Med Chem Lett
; 71: 128807, 2022 09 01.
Article
in English
| MEDLINE | ID: mdl-35605837
3.
Discovery of nonpeptide 3,4-dihydroquinazoline-4-carboxamides as potent and selective sst2 agonists.
Bioorg Med Chem Lett
; 30(17): 127391, 2020 09 01.
Article
in English
| MEDLINE | ID: mdl-32738999
4.
Discovery of substituted 3H-pyrido[2,3-d]pyrimidin-4-ones as potent, biased, and orally bioavailable sst2 agonist.
Bioorg Med Chem Lett
; 30(21): 127496, 2020 11 01.
Article
in English
| MEDLINE | ID: mdl-32805408
5.
Discovery of Paltusotine (CRN00808), a Potent, Selective, and Orally Bioavailable Non-peptide SST2 Agonist.
ACS Med Chem Lett
; 14(1): 66-74, 2023 Jan 12.
Article
in English
| MEDLINE | ID: mdl-36655128
6.
Chemical genetics approach to restoring p27Kip1 reveals novel compounds with antiproliferative activity in prostate cancer cells.
BMC Biol
; 8: 153, 2010 Dec 23.
Article
in English
| MEDLINE | ID: mdl-21182779
7.
Suppressor of cytokine signaling (SOCS) 2, a protein with multiple functions.
Cytokine Growth Factor Rev
; 17(6): 431-9, 2006 Dec.
Article
in English
| MEDLINE | ID: mdl-17070092
8.
SOCS2 negatively regulates growth hormone action in vitro and in vivo.
J Clin Invest
; 115(2): 397-406, 2005 Feb.
Article
in English
| MEDLINE | ID: mdl-15690087
9.
In vivo transcript profiling and phylogenetic analysis identifies suppressor of cytokine signaling 2 as a direct signal transducer and activator of transcription 5b target in liver.
Mol Endocrinol
; 21(1): 293-311, 2007 Jan.
Article
in English
| MEDLINE | ID: mdl-17008382
10.
Oxidized analogs of Di(1H-indol-3-yl)methyl-4-substituted benzenes are NR4A1-dependent UPR inducers with potent and safe anti-cancer activity.
Oncotarget
; 9(38): 25057-25074, 2018 May 18.
Article
in English
| MEDLINE | ID: mdl-29861853
11.
Negative regulation of growth hormone receptor signaling.
Mol Endocrinol
; 20(2): 241-53, 2006 Feb.
Article
in English
| MEDLINE | ID: mdl-16037128
12.
Suppressor of cytokine signaling-2 deficiency induces molecular and metabolic changes that partially overlap with growth hormone-dependent effects.
Mol Endocrinol
; 19(3): 781-93, 2005 Mar.
Article
in English
| MEDLINE | ID: mdl-15563548
13.
Female-predominant expression of fatty acid translocase/CD36 in rat and human liver.
Endocrinology
; 145(4): 1972-9, 2004 Apr.
Article
in English
| MEDLINE | ID: mdl-14684613
14.
Small molecule-induced mitochondrial disruption directs prostate cancer inhibition via UPR signaling.
Oncotarget
; 4(8): 1212-29, 2013 Aug.
Article
in English
| MEDLINE | ID: mdl-23902736
15.
Relative impact of 3- and 5-hydroxyl groups of cytosporone B on cancer cell viability.
Medchemcomm
; 4(2): 332-339, 2013 Feb 01.
Article
in English
| MEDLINE | ID: mdl-24795803
16.
Skipping cancer: small molecule inhibitors of SKP2-mediated p27 degradation.
Chem Biol
; 19(12): 1497-8, 2012 Dec 21.
Article
in English
| MEDLINE | ID: mdl-23261592
17.
Downregulation of the growth hormone-induced Janus kinase 2/signal transducer and activator of transcription 5 signaling pathway requires an intact actin cytoskeleton.
Exp Cell Res
; 294(1): 269-80, 2004 Mar 10.
Article
in English
| MEDLINE | ID: mdl-14980520
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