Search details
1.
Biased M1-muscarinic-receptor-mutant mice inform the design of next-generation drugs.
Nat Chem Biol
; 16(3): 240-249, 2020 03.
Article
in English
| MEDLINE | ID: mdl-32080630
2.
The inhibition of human lung fibroblast proliferation and differentiation by Gs-coupled receptors is not predicted by the magnitude of cAMP response.
Respir Res
; 19(1): 56, 2018 04 07.
Article
in English
| MEDLINE | ID: mdl-29625570
3.
Long Receptor Residence Time of C26 Contributes to Super Agonist Activity at the Human ß2 Adrenoceptor.
Mol Pharmacol
; 89(4): 467-75, 2016 Apr.
Article
in English
| MEDLINE | ID: mdl-26772612
4.
Identification of novel IP receptor agonists using historical ligand biased chemical arrays.
Bioorg Med Chem Lett
; 24(10): 2247-50, 2014 May 15.
Article
in English
| MEDLINE | ID: mdl-24736116
5.
Key aspects of modern GPCR drug discovery.
SLAS Discov
; 29(1): 1-22, 2024 Jan.
Article
in English
| MEDLINE | ID: mdl-37625784
6.
M3-muscarinic receptor promotes insulin release via receptor phosphorylation/arrestin-dependent activation of protein kinase D1.
Proc Natl Acad Sci U S A
; 107(49): 21181-6, 2010 Dec 07.
Article
in English
| MEDLINE | ID: mdl-21078968
7.
The M3-muscarinic receptor regulates learning and memory in a receptor phosphorylation/arrestin-dependent manner.
Proc Natl Acad Sci U S A
; 107(20): 9440-5, 2010 May 18.
Article
in English
| MEDLINE | ID: mdl-20439723
8.
Analysis of multiple histamine H4 receptor compound classes uncovers Gαi protein- and ß-arrestin2-biased ligands.
Mol Pharmacol
; 82(6): 1174-82, 2012 Dec.
Article
in English
| MEDLINE | ID: mdl-22973061
9.
Endomorphin-2: a biased agonist at the µ-opioid receptor.
Mol Pharmacol
; 82(2): 178-88, 2012 Aug.
Article
in English
| MEDLINE | ID: mdl-22553358
10.
An investigation into the structure-activity relationships associated with the systematic modification of the ß(2)-adrenoceptor agonist indacaterol.
Bioorg Med Chem Lett
; 22(19): 6280-5, 2012 Oct 01.
Article
in English
| MEDLINE | ID: mdl-22932315
11.
Agonist-biased signaling at the histamine H4 receptor: JNJ7777120 recruits ß-arrestin without activating G proteins.
Mol Pharmacol
; 79(4): 749-57, 2011 Apr.
Article
in English
| MEDLINE | ID: mdl-21134907
12.
Inhibition of the Proliferation of Human Lung Fibroblasts by Prostacyclin Receptor Agonists is Linked to a Sustained cAMP Signal in the Nucleus.
Front Pharmacol
; 12: 669227, 2021.
Article
in English
| MEDLINE | ID: mdl-33995100
13.
µ-opioid receptors: correlation of agonist efficacy for signalling with ability to activate internalization.
Mol Pharmacol
; 78(4): 756-66, 2010 Oct.
Article
in English
| MEDLINE | ID: mdl-20647394
14.
Airway remodeling disease: primary human structural cells and phenotypic and pathway assays to identify targets with potential to prevent or reverse remodeling.
J Exp Pharmacol
; 10: 75-85, 2018.
Article
in English
| MEDLINE | ID: mdl-30568517
15.
Endogenous lysophosphatidic acid (LPA1 ) receptor agonists demonstrate ligand bias between calcium and ERK signalling pathways in human lung fibroblasts.
Br J Pharmacol
; 174(3): 227-237, 2017 02.
Article
in English
| MEDLINE | ID: mdl-27864940
16.
Functional desensitization of the ß 2 adrenoceptor is not dependent on agonist efficacy.
Pharmacol Res Perspect
; 3(1): e00101, 2015 Feb.
Article
in English
| MEDLINE | ID: mdl-25692019
17.
ATP priming of macrophage-derived chemokine responses in CHO cells expressing the CCR4 receptor.
Naunyn Schmiedebergs Arch Pharmacol
; 370(1): 64-70, 2004 Jul.
Article
in English
| MEDLINE | ID: mdl-15167983
18.
High throughput mutagenesis for identification of residues regulating human prostacyclin (hIP) receptor expression and function.
PLoS One
; 9(6): e97973, 2014.
Article
in English
| MEDLINE | ID: mdl-24886841
19.
The use of cold plasma technology to reduce carryover in screening assays.
J Lab Autom
; 18(4): 269-75, 2013 Aug.
Article
in English
| MEDLINE | ID: mdl-22983566
20.
Efficacy is a contributing factor to the clinical onset of bronchodilation of inhaled beta(2)-adrenoceptor agonists.
Naunyn Schmiedebergs Arch Pharmacol
; 382(3): 255-63, 2010 Sep.
Article
in English
| MEDLINE | ID: mdl-20694793