Search | Virtual Health Library

1.

Structural and signaling mechanisms of TAAR1 enabled preferential agonist design.

Shang, Pan; Rong, Naikang; Jiang, Jing-Jing; Cheng, Jie; Zhang, Ming-Hui; Kang, Dongwei; Qi, Lei; Guo, Lulu; Yang, Gong-Ming; Liu, Qun; Zhou, Zhenzhen; Li, Xiao-Bing; Zhu, Kong-Kai; Meng, Qing-Biao; Han, Xiang; Yan, Wenqi; Kong, Yalei; Yang, Lejin; Wang, Xiaohui; Lei, Dapeng; Feng, Xin; Liu, Xinyong; Yu, Xiao; Wang, Yue; Li, Qian; Shao, Zhen-Hua; Yang, Fan; Sun, Jin-Peng.

Cell ; 186(24): 5347-5362.e24, 2023 11 22.

Article in English | MEDLINE | ID: mdl-37963465

2.

Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes.

Xiao, Peng; Yan, Wei; Gou, Lu; Zhong, Ya-Ni; Kong, Liangliang; Wu, Chao; Wen, Xin; Yuan, Yuan; Cao, Sheng; Qu, Changxiu; Yang, Xin; Yang, Chuan-Cheng; Xia, Anjie; Hu, Zhenquan; Zhang, Qianqian; He, Yong-Hao; Zhang, Dao-Lai; Zhang, Chao; Hou, Gui-Hua; Liu, Huanxiang; Zhu, Lizhe; Fu, Ping; Yang, Shengyong; Rosenbaum, Daniel M; Sun, Jin-Peng; Du, Yang; Zhang, Lei; Yu, Xiao; Shao, Zhenhua.

Cell ; 184(4): 943-956.e18, 2021 02 18.

Article in English | MEDLINE | ID: mdl-33571432

3.

Biased allosteric activation of ketone body receptor HCAR2 suppresses inflammation.

Zhao, Chang; Wang, Heli; Liu, Ying; Cheng, Lin; Wang, Bo; Tian, Xiaowen; Fu, Hong; Wu, Chao; Li, Ziyan; Shen, Chenglong; Yu, Jingjing; Yang, Shengyong; Hu, Hongbo; Fu, Ping; Ma, Liang; Wang, Chuanxin; Yan, Wei; Shao, Zhenhua.

Mol Cell ; 83(17): 3171-3187.e7, 2023 09 07.

Article in English | MEDLINE | ID: mdl-37597514

4.

Ligand recognition and G-protein coupling of trace amine receptor TAAR1.

Xu, Zheng; Guo, Lulu; Yu, Jingjing; Shen, Siyuan; Wu, Chao; Zhang, Weifeng; Zhao, Chang; Deng, Yue; Tian, Xiaowen; Feng, Yuying; Hou, Hanlin; Su, Lantian; Wang, Hongshuang; Guo, Shuo; Wang, Heli; Wang, Kexin; Chen, Peipei; Zhao, Jie; Zhang, Xiaoyu; Yong, Xihao; Cheng, Lin; Liu, Lunxu; Yang, Shengyong; Yang, Fan; Wang, Xiaohui; Yu, Xiao; Xu, Yunfei; Sun, Jin-Peng; Yan, Wei; Shao, Zhenhua.

Nature ; 624(7992): 672-681, 2023 Dec.

Article in English | MEDLINE | ID: mdl-37935376

5.

Structure-based identification of a G protein-biased allosteric modulator of cannabinoid receptor CB1.

Shen, Siyuan; Wu, Chao; Lin, Guifeng; Yang, Xin; Zhou, Yangli; Zhao, Chang; Miao, Zhuang; Tian, Xiaowen; Wang, Kexin; Yang, Zhiqian; Liu, Zhiyu; Guo, Nihong; Li, Yueshan; Xia, Anjie; Zhou, Pei; Liu, Jingming; Yan, Wei; Ke, Bowen; Yang, Shengyong; Shao, Zhenhua.

Proc Natl Acad Sci U S A ; 121(24): e2321532121, 2024 Jun 11.

Article in English | MEDLINE | ID: mdl-38830102

6.

Cryo-EM structures of human GPR34 enable the identification of selective antagonists.

Xia, Anjie; Yong, Xihao; Zhang, Changbin; Lin, Guifeng; Jia, Guowen; Zhao, Chang; Wang, Xin; Hao, Yize; Wang, Yifei; Zhou, Pei; Yang, Xin; Deng, Yue; Wu, Chao; Chen, Yujiao; Zhu, Jiawei; Tang, Xiaodi; Liu, Jingming; Zhang, Shiyu; Zhang, Jiahao; Xu, Zheng; Hu, Qian; Zhao, Jinlong; Yue, Yuting; Yan, Wei; Su, Zhaoming; Wei, Yuquan; Zhou, Rongbin; Dong, Haohao; Shao, Zhenhua; Yang, Shengyong.

Proc Natl Acad Sci U S A ; 120(39): e2308435120, 2023 09 26.

Article in English | MEDLINE | ID: mdl-37733739

7.

The critical role of P2XR/PGC-1α signalling pathway in hypoxia-mediated pyroptosis and M1/M2 phenotypic differentiation of mouse microglia.

Yang, Hao; Shao, Zhen-Hua; Jin, Xian; Chen, Jia-Wei.

Eur J Neurosci ; 2024 May 02.

Article in English | MEDLINE | ID: mdl-38697919

8.

Molecular mechanism of allosteric modulation for the cannabinoid receptor CB1.

Yang, Xin; Wang, Xuehui; Xu, Zheng; Wu, Chao; Zhou, Yangli; Wang, Yifei; Lin, Guifeng; Li, Kan; Wu, Ming; Xia, Anjie; Liu, Jingming; Cheng, Lin; Zou, Jun; Yan, Wei; Shao, Zhenhua; Yang, Shengyong.

Nat Chem Biol ; 18(8): 831-840, 2022 08.

Article in English | MEDLINE | ID: mdl-35637350

9.

Evolution of GCGR family ligand-receptor extensive cross-interaction systems suggests a therapeutic direction for hyperglycemia in mammals.

Liu, Jian; Wang, Xue; Zhang, Wenli; Liao, Guangneng; Shao, Zhenhua; Brosius, Juergen; Deng, Cheng; Lai, Shanshan; Long, Enwu.

Acta Biochim Biophys Sin (Shanghai) ; 55(12): 1855-1863, 2023 12 25.

Article in English | MEDLINE | ID: mdl-37969012

10.

High-resolution crystal structure of the human CB1 cannabinoid receptor.

Shao, Zhenhua; Yin, Jie; Chapman, Karen; Grzemska, Magdalena; Clark, Lindsay; Wang, Junmei; Rosenbaum, Daniel M.

Nature ; 540(7634): 602-606, 2016 Dec 22.

Article in English | MEDLINE | ID: mdl-27851727

11.

Structure of an allosteric modulator bound to the CB1 cannabinoid receptor.

Shao, Zhenhua; Yan, Wei; Chapman, Karen; Ramesh, Karthik; Ferrell, Aaron J; Yin, Jie; Wang, Xuehui; Xu, Qingping; Rosenbaum, Daniel M.

Nat Chem Biol ; 15(12): 1199-1205, 2019 12.

Article in English | MEDLINE | ID: mdl-31659318

12.

Crystal structure of the human NK₁ tachykinin receptor.

Yin, Jie; Chapman, Karen; Clark, Lindsay D; Shao, Zhenhua; Borek, Dominika; Xu, Qingping; Wang, Junmei; Rosenbaum, Daniel M.

Proc Natl Acad Sci U S A ; 115(52): 13264-13269, 2018 12 26.

Article in English | MEDLINE | ID: mdl-30538204

13.

Autophagy mitigates high-temperature injury in pollen development of Arabidopsis thaliana.

Dündar, Gönül; Shao, Zhenhua; Higashitani, Nahoko; Kikuta, Mami; Izumi, Masanori; Higashitani, Atsushi.

Dev Biol ; 456(2): 190-200, 2019 12 15.

Article in English | MEDLINE | ID: mdl-31473188

14.

Gain-switched laser diode seeded TDFA with 409 W picosecond pulses and 142 W spectrally flat supercontinuum output.

Yao, Weichao; Shao, Zhenhua; Shen, Chongfeng; Tang, Jinwen; Zhao, Yongguang; Shen, Deyuan.

Opt Express ; 27(2): 1276-1282, 2019 Jan 21.

Article in English | MEDLINE | ID: mdl-30696196

15.

High-power nanosecond pulse generation from an integrated Tm-Ho fiber MOPA over 2.1 µm.

Yao, Weichao; Shen, Chongfeng; Shao, Zhenhua; Liu, Qiyao; Wang, Haotian; Zhao, Yongguang; Shen, Deyuan.

Opt Express ; 26(7): 8841-8848, 2018 Apr 02.

Article in English | MEDLINE | ID: mdl-29715846

16.

Lighting up cholecystokinin.

Cheng, Lin; Shao, Zhenhua.

Nat Chem Biol ; 17(12): 1213-1214, 2021 12.

Article in English | MEDLINE | ID: mdl-34556861

17.

790 W incoherent beam combination of a Tm-doped fiber laser at 1941 nm using a 3 × 1 signal combiner.

Yao, Weichao; Shen, Chongfeng; Shao, Zhenhua; Wang, Jianlei; Wang, Fei; Zhao, Yongguang; Shen, Deyuan.

Appl Opt ; 57(20): 5574-5577, 2018 Jul 10.

Article in English | MEDLINE | ID: mdl-30118066

18.

Overview of Advanced LIGO adaptive optics.

Brooks, Aidan F; Abbott, Benjamin; Arain, Muzammil A; Ciani, Giacomo; Cole, Ayodele; Grabeel, Greg; Gustafson, Eric; Guido, Chris; Heintze, Matthew; Heptonstall, Alastair; Jacobson, Mindy; Kim, Won; King, Eleanor; Lynch, Alexander; O'Connor, Stephen; Ottaway, David; Mailand, Ken; Mueller, Guido; Munch, Jesper; Sannibale, Virginio; Shao, Zhenhua; Smith, Michael; Veitch, Peter; Vo, Thomas; Vorvick, Cheryl; Willems, Phil.

Appl Opt ; 55(29): 8256-8265, 2016 Oct 10.

Article in English | MEDLINE | ID: mdl-27828071

19.

Crystal structure of tRNA m1G9 methyltransferase Trm10: insight into the catalytic mechanism and recognition of tRNA substrate.

Shao, Zhenhua; Yan, Wei; Peng, Junhui; Zuo, Xiaobing; Zou, Yang; Li, Fudong; Gong, Deshun; Ma, Rongsheng; Wu, Jihui; Shi, Yunyu; Zhang, Zhiyong; Teng, Maikun; Li, Xu; Gong, Qingguo.

Nucleic Acids Res ; 42(1): 509-25, 2014 Jan.

Article in English | MEDLINE | ID: mdl-24081582

20.

Multi-order Stokes output based on intra-cavity KTiOAsO4 Raman crystal.

Zhu, Haiyong; Shao, Zhenhua; Wang, Hongyan; Duan, Yanmin; Zhang, Jian; Tang, Dingyuan; Kaminskii, A A.

Opt Express ; 22(16): 19662-7, 2014 Aug 11.

Article in English | MEDLINE | ID: mdl-25321049

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