Search | Virtual Health Library

1.

Loss of ribonuclease DIS3 hampers genome integrity in myeloma by disrupting DNA:RNA hybrid metabolism.

Gritti, Ilaria; Basso, Veronica; Rinchai, Darawan; Corigliano, Federica; Pivetti, Silvia; Gaviraghi, Marco; Rosano, Dalia; Mazza, Davide; Barozzi, Sara; Roncador, Marco; Parmigiani, Giovanni; Legube, Gaelle; Parazzoli, Dario; Cittaro, Davide; Bedognetti, Davide; Mondino, Anna; Segalla, Simona; Tonon, Giovanni.

EMBO J ; 41(22): e108040, 2022 11 17.

Article in English | MEDLINE | ID: mdl-36215697

2.

Myeloma and DNA damage.

Tonon, Giovanni.

Blood ; 143(6): 488-495, 2024 Feb 08.

Article in English | MEDLINE | ID: mdl-37992215

3.

Scalable integration of multiomic single-cell data using generative adversarial networks.

Giansanti, Valentina; Giannese, Francesca; Botrugno, Oronza A; Gandolfi, Giorgia; Balestrieri, Chiara; Antoniotti, Marco; Tonon, Giovanni; Cittaro, Davide.

Bioinformatics ; 40(5)2024 May 02.

Article in English | MEDLINE | ID: mdl-38696763

4.

Revealing and harnessing CD39 for the treatment of colorectal cancer and liver metastases by engineered T cells.

Potenza, Alessia; Balestrieri, Chiara; Spiga, Martina; Albarello, Luca; Pedica, Federica; Manfredi, Francesco; Cianciotti, Beatrice Claudia; De Lalla, Claudia; Botrugno, Oronza A; Faccani, Cristina; Stasi, Lorena; Tassi, Elena; Bonfiglio, Silvia; Scotti, Giulia Maria; Redegalli, Miriam; Biancolini, Donatella; Camisa, Barbara; Tiziano, Elena; Sirini, Camilla; Casucci, Monica; Iozzi, Chiara; Abbati, Danilo; Simeoni, Fabio; Lazarevic, Dejan; Elmore, Ugo; Fiorentini, Guido; Di Lullo, Giulia; Casorati, Giulia; Doglioni, Claudio; Tonon, Giovanni; Dellabona, Paolo; Rosati, Riccardo; Aldrighetti, Luca; Ruggiero, Eliana; Bonini, Chiara.

Gut ; 72(10): 1887-1903, 2023 10.

Article in English | MEDLINE | ID: mdl-37399271

5.

Gold(I)-N-Heterocyclic Carbene Synthons in Organometallic Synthesis.

Scattolin, Thomas; Tonon, Giovanni; Botter, Eleonora; Guillet, Sebastien G; Tzouras, Nikolaos V; Nolan, Steven P.

Chemistry ; 29(58): e202301961, 2023 Oct 18.

Article in English | MEDLINE | ID: mdl-37463071

6.

Tumor suppressor PNRC1 blocks rRNA maturation by recruiting the decapping complex to the nucleolus.

Gaviraghi, Marco; Vivori, Claudia; Pareja Sanchez, Yerma; Invernizzi, Francesca; Cattaneo, Angela; Santoliquido, Benedetta Maria; Frenquelli, Michela; Segalla, Simona; Bachi, Angela; Doglioni, Claudio; Pelechano, Vicent; Cittaro, Davide; Tonon, Giovanni.

EMBO J ; 37(23)2018 12 03.

Article in English | MEDLINE | ID: mdl-30373810

7.

Chest CT in the emergency department for suspected COVID-19 pneumonia.

Palmisano, Anna; Scotti, Giulia Maria; Ippolito, Davide; Morelli, Marco J; Vignale, Davide; Gandola, Davide; Sironi, Sandro; De Cobelli, Francesco; Ferrante, Luca; Spessot, Marzia; Tonon, Giovanni; Tacchetti, Carlo; Esposito, Antonio.

Radiol Med ; 126(3): 498-502, 2021 Mar.

Article in English | MEDLINE | ID: mdl-33165767

8.

ATR addiction in multiple myeloma: synthetic lethal approaches exploiting established therapies.

Botrugno, Oronza A; Bianchessi, Silvia; Zambroni, Desirée; Frenquelli, Michela; Belloni, Daniela; Bongiovanni, Lucia; Girlanda, Stefania; Di Terlizzi, Simona; Ferrarini, Marina; Ferrero, Elisabetta; Ponzoni, Maurilio; Marcatti, Magda; Tonon, Giovanni.

Haematologica ; 105(10): 2440-2447, 2020 10 01.

Article in English | MEDLINE | ID: mdl-33054085

9.

Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia.

Ntziachristos, Panagiotis; Tsirigos, Aristotelis; Welstead, G Grant; Trimarchi, Thomas; Bakogianni, Sofia; Xu, Luyao; Loizou, Evangelia; Holmfeldt, Linda; Strikoudis, Alexandros; King, Bryan; Mullenders, Jasper; Becksfort, Jared; Nedjic, Jelena; Paietta, Elisabeth; Tallman, Martin S; Rowe, Jacob M; Tonon, Giovanni; Satoh, Takashi; Kruidenier, Laurens; Prinjha, Rab; Akira, Shizuo; Van Vlierberghe, Pieter; Ferrando, Adolfo A; Jaenisch, Rudolf; Mullighan, Charles G; Aifantis, Iannis.

Nature ; 514(7523): 513-7, 2014 Oct 23.

Article in English | MEDLINE | ID: mdl-25132549

10.

Che-1-induced inhibition of mTOR pathway enables stress-induced autophagy.

Desantis, Agata; Bruno, Tiziana; Catena, Valeria; De Nicola, Francesca; Goeman, Frauke; Iezzi, Simona; Sorino, Cristina; Ponzoni, Maurilio; Bossi, Gianluca; Federico, Vincenzo; La Rosa, Francesca; Ricciardi, Maria Rosaria; Lesma, Elena; De Meo, Paolo D'Onorio; Castrignanò, Tiziana; Petrucci, Maria Teresa; Pisani, Francesco; Chesi, Marta; Bergsagel, P Leif; Floridi, Aristide; Tonon, Giovanni; Passananti, Claudio; Blandino, Giovanni; Fanciulli, Maurizio.

EMBO J ; 34(9): 1214-30, 2015 May 05.

Article in English | MEDLINE | ID: mdl-25770584

11.

Pancreatic cancers require autophagy for tumor growth.

Yang, Shenghong; Wang, Xiaoxu; Contino, Gianmarco; Liesa, Marc; Sahin, Ergun; Ying, Haoqiang; Bause, Alexandra; Li, Yinghua; Stommel, Jayne M; Dell'antonio, Giacomo; Mautner, Josef; Tonon, Giovanni; Haigis, Marcia; Shirihai, Orian S; Doglioni, Claudio; Bardeesy, Nabeel; Kimmelman, Alec C.

Genes Dev ; 25(7): 717-29, 2011 Apr 01.

Article in English | MEDLINE | ID: mdl-21406549

12.

The winding road toward the myeloma mouse.

Tonon, Giovanni.

Blood ; 137(1): 7-8, 2021 01 07.

Article in English | MEDLINE | ID: mdl-33410904

13.

HIF-1α regulates the interaction of chronic lymphocytic leukemia cells with the tumor microenvironment.

Valsecchi, Roberta; Coltella, Nadia; Belloni, Daniela; Ponente, Manfredi; Ten Hacken, Elisa; Scielzo, Cristina; Scarfò, Lydia; Bertilaccio, Maria Teresa Sabrina; Brambilla, Paola; Lenti, Elisa; Martinelli Boneschi, Filippo; Brendolan, Andrea; Ferrero, Elisabetta; Ferrarini, Marina; Ghia, Paolo; Tonon, Giovanni; Ponzoni, Maurilio; Caligaris-Cappio, Federico; Bernardi, Rosa.

Blood ; 127(16): 1987-97, 2016 Apr 21.

Article in English | MEDLINE | ID: mdl-26825709

14.

Modeling multiple myeloma-bone marrow interactions and response to drugs in a 3D surrogate microenvironment.

Belloni, Daniela; Heltai, Silvia; Ponzoni, Maurilio; Villa, Antonello; Vergani, Barbara; Pecciarini, Lorenza; Marcatti, Magda; Girlanda, Stefania; Tonon, Giovanni; Ciceri, Fabio; Caligaris-Cappio, Federico; Ferrarini, Marina; Ferrero, Elisabetta.

Haematologica ; 103(4): 707-716, 2018 04.

Article in English | MEDLINE | ID: mdl-29326121

15.

Highly similar genomic landscapes in monoclonal B-cell lymphocytosis and ultra-stable chronic lymphocytic leukemia with low frequency of driver mutations.

Agathangelidis, Andreas; Ljungström, Viktor; Scarfò, Lydia; Fazi, Claudia; Gounari, Maria; Pandzic, Tatjana; Sutton, Lesley-Ann; Stamatopoulos, Kostas; Tonon, Giovanni; Rosenquist, Richard; Ghia, Paolo.

Haematologica ; 103(5): 865-873, 2018 05.

Article in English | MEDLINE | ID: mdl-29449433

16.

Structural basis for PHDVC5HCHNSD1-C2HRNizp1 interaction: implications for Sotos syndrome.

Berardi, Andrea; Quilici, Giacomo; Spiliotopoulos, Dimitrios; Corral-Rodriguez, Maria Angeles; Martin-Garcia, Fernando; Degano, Massimo; Tonon, Giovanni; Ghitti, Michela; Musco, Giovanna.

Nucleic Acids Res ; 44(7): 3448-63, 2016 Apr 20.

Article in English | MEDLINE | ID: mdl-26896805

17.

p63 Sustains self-renewal of mammary cancer stem cells through regulation of Sonic Hedgehog signaling.

Memmi, Elisa Maria; Sanarico, Anna Giulia; Giacobbe, Arianna; Peschiaroli, Angelo; Frezza, Valentina; Cicalese, Angelo; Pisati, Federica; Tosoni, Daniela; Zhou, Huiqing; Tonon, Giovanni; Antonov, Alexey; Melino, Gerry; Pelicci, Pier Giuseppe; Bernassola, Francesca.

Proc Natl Acad Sci U S A ; 112(11): 3499-504, 2015 Mar 17.

Article in English | MEDLINE | ID: mdl-25739959

18.

Telomere dysfunction induces metabolic and mitochondrial compromise.

Sahin, Ergün; Colla, Simona; Liesa, Marc; Moslehi, Javid; Müller, Florian L; Guo, Mira; Cooper, Marcus; Kotton, Darrell; Fabian, Attila J; Walkey, Carl; Maser, Richard S; Tonon, Giovanni; Foerster, Friedrich; Xiong, Robert; Wang, Y Alan; Shukla, Sachet A; Jaskelioff, Mariela; Martin, Eric S; Heffernan, Timothy P; Protopopov, Alexei; Ivanova, Elena; Mahoney, John E; Kost-Alimova, Maria; Perry, Samuel R; Bronson, Roderick; Liao, Ronglih; Mulligan, Richard; Shirihai, Orian S; Chin, Lynda; DePinho, Ronald A.

Nature ; 470(7334): 359-65, 2011 Feb 17.

Article in English | MEDLINE | ID: mdl-21307849

19.

H3K4me3 demethylation by the histone demethylase KDM5C/JARID1C promotes DNA replication origin firing.

Rondinelli, Beatrice; Schwerer, Hélène; Antonini, Elena; Gaviraghi, Marco; Lupi, Alessio; Frenquelli, Michela; Cittaro, Davide; Segalla, Simona; Lemaitre, Jean-Marc; Tonon, Giovanni.

Nucleic Acids Res ; 43(5): 2560-74, 2015 Mar 11.

Article in English | MEDLINE | ID: mdl-25712104

20.

The ribonuclease DIS3 promotes let-7 miRNA maturation by degrading the pluripotency factor LIN28B mRNA.

Segalla, Simona; Pivetti, Silvia; Todoerti, Katia; Chudzik, Malgorzata Agata; Giuliani, Erica Claudia; Lazzaro, Federico; Volta, Viviana; Lazarevic, Dejan; Musco, Giovanna; Muzi-Falconi, Marco; Neri, Antonino; Biffo, Stefano; Tonon, Giovanni.

Nucleic Acids Res ; 43(10): 5182-93, 2015 May 26.

Article in English | MEDLINE | ID: mdl-25925570

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