Search | Virtual Health Library

1.

AKIRIN2 controls the nuclear import of proteasomes in vertebrates.

de Almeida, Melanie; Hinterndorfer, Matthias; Brunner, Hanna; Grishkovskaya, Irina; Singh, Kashish; Schleiffer, Alexander; Jude, Julian; Deswal, Sumit; Kalis, Robert; Vunjak, Milica; Lendl, Thomas; Imre, Richard; Roitinger, Elisabeth; Neumann, Tobias; Kandolf, Susanne; Schutzbier, Michael; Mechtler, Karl; Versteeg, Gijs A; Haselbach, David; Zuber, Johannes.

Nature ; 599(7885): 491-496, 2021 11.

Article in English | MEDLINE | ID: mdl-34711951

2.

Lipocalin 2 modulates dendritic cell activity and shapes immunity to influenza in a microbiome dependent manner.

Watzenboeck, Martin L; Drobits, Barbara; Zahalka, Sophie; Gorki, Anna-Dorothea; Farhat, Asma; Quattrone, Federica; Hladik, Anastasiya; Lakovits, Karin; Richard, Gabriel M; Lederer, Therese; Strobl, Birgit; Versteeg, Gijs A; Boon, Louis; Starkl, Philipp; Knapp, Sylvia.

PLoS Pathog ; 17(4): e1009487, 2021 04.

Article in English | MEDLINE | ID: mdl-33905460

3.

Unanchored K48-linked polyubiquitin synthesized by the E3-ubiquitin ligase TRIM6 stimulates the interferon-IKKÎµ kinase-mediated antiviral response.

Rajsbaum, Ricardo; Versteeg, Gijs A; Schmid, Sonja; Maestre, Ana M; Belicha-Villanueva, Alan; Martínez-Romero, Carles; Patel, Jenish R; Morrison, Juliet; Pisanelli, Giuseppe; Miorin, Lisa; Laurent-Rolle, Maudry; Moulton, Hong M; Stein, David A; Fernandez-Sesma, Ana; tenOever, Benjamin R; García-Sastre, Adolfo.

Immunity ; 40(6): 880-95, 2014 Jun 19.

Article in English | MEDLINE | ID: mdl-24882218

4.

The E3-ligase TRIM family of proteins regulates signaling pathways triggered by innate immune pattern-recognition receptors.

Versteeg, Gijs A; Rajsbaum, Ricardo; Sánchez-Aparicio, Maria Teresa; Maestre, Ana M; Valdiviezo, Julio; Shi, Mude; Inn, Kyung-Soo; Fernandez-Sesma, Ana; Jung, Jae; García-Sastre, Adolfo.

Immunity ; 38(2): 384-98, 2013 Feb 21.

Article in English | MEDLINE | ID: mdl-23438823

5.

Ubiquitin enzymes in the regulation of immune responses.

Ebner, Petra; Versteeg, Gijs A; Ikeda, Fumiyo.

Crit Rev Biochem Mol Biol ; 52(4): 425-460, 2017 08.

Article in English | MEDLINE | ID: mdl-28524749

6.

Species-specific inhibition of RIG-I ubiquitination and IFN induction by the influenza A virus NS1 protein.

Rajsbaum, Ricardo; Albrecht, Randy A; Wang, May K; Maharaj, Natalya P; Versteeg, Gijs A; Nistal-Villán, Estanislao; García-Sastre, Adolfo; Gack, Michaela U.

PLoS Pathog ; 8(11): e1003059, 2012.

Article in English | MEDLINE | ID: mdl-23209422

7.

Chemical inhibition of RNA viruses reveals REDD1 as a host defense factor.

Mata, Miguel A; Satterly, Neal; Versteeg, Gijs A; Frantz, Doug; Wei, Shuguang; Williams, Noelle; Schmolke, Mirco; Peña-Llopis, Samuel; Brugarolas, James; Forst, Christian V; White, Michael A; García-Sastre, Adolfo; Roth, Michael G; Fontoura, Beatriz M A.

Nat Chem Biol ; 7(10): 712-9, 2011 Sep 11.

Article in English | MEDLINE | ID: mdl-21909097

8.

Structural basis for regulation of apoptosis and autophagy by the BIRC6/SMAC complex.

Ehrmann, Julian F; Grabarczyk, Daniel B; Heinke, Maria; Deszcz, Luiza; Kurzbauer, Robert; Hudecz, Otto; Shulkina, Alexandra; Gogova, Rebeca; Meinhart, Anton; Versteeg, Gijs A; Clausen, Tim.

Science ; 379(6637): 1117-1123, 2023 03 17.

Article in English | MEDLINE | ID: mdl-36758105

9.

HUWE1 controls tristetraprolin proteasomal degradation by regulating its phosphorylation.

Scinicariello, Sara; Soderholm, Adrian; Schäfer, Markus; Shulkina, Alexandra; Schwartz, Irene; Hacker, Kathrin; Gogova, Rebeca; Kalis, Robert; Froussios, Kimon; Budroni, Valentina; Bestehorn, Annika; Clausen, Tim; Kovarik, Pavel; Zuber, Johannes; Versteeg, Gijs A.

Elife ; 122023 03 24.

Article in English | MEDLINE | ID: mdl-36961408

10.

SPOP targets the immune transcription factor IRF1 for proteasomal degradation.

Schwartz, Irene; Vunjak, Milica; Budroni, Valentina; Cantoran García, Adriana; Mastrovito, Marialaura; Soderholm, Adrian; Hinterndorfer, Matthias; de Almeida, Melanie; Hacker, Kathrin; Wang, Jingkui; Froussios, Kimon; Jude, Julian; Decker, Thomas; Zuber, Johannes; Versteeg, Gijs A.

Elife ; 122023 08 25.

Article in English | MEDLINE | ID: mdl-37622993

11.

Species-specific antagonism of host ISGylation by the influenza B virus NS1 protein.

Versteeg, Gijs A; Hale, Benjamin G; van Boheemen, Sander; Wolff, Thorsten; Lenschow, Deborah J; García-Sastre, Adolfo.

J Virol ; 84(10): 5423-30, 2010 May.

Article in English | MEDLINE | ID: mdl-20219937

12.

Negative Regulation of the Innate Immune Response through Proteasomal Degradation and Deubiquitination.

Budroni, Valentina; Versteeg, Gijs A.

Viruses ; 13(4)2021 03 30.

Article in English | MEDLINE | ID: mdl-33808506

13.

TRIM proteins.

Vunjak, Milica; Versteeg, Gijs A.

Curr Biol ; 29(2): R42-R44, 2019 01 21.

Article in English | MEDLINE | ID: mdl-30668943

14.

A repetitive acidic region contributes to the extremely rapid degradation of the cell-context essential protein TRIM52.

Hacker, Kathrin; Benke, Stefan; Agerer, Benedikt; Scinicariello, Sara; Budroni, Valentina; Versteeg, Gijs A.

Sci Rep ; 9(1): 7901, 2019 05 27.

Article in English | MEDLINE | ID: mdl-31133683

15.

Human tripartite motif protein 52 is required for cell context-dependent proliferation.

Benke, Stefan; Agerer, Benedikt; Haas, Lisa; Stöger, Martin; Lercher, Alexander; Gabler, Lisa; Kiss, Izabella; Scinicariello, Sara; Berger, Walter; Bergthaler, Andreas; Obenauf, Anna C; Versteeg, Gijs A.

Oncotarget ; 9(17): 13565-13581, 2018 Mar 02.

Article in English | MEDLINE | ID: mdl-29568378

16.

TRIMmunity: the roles of the TRIM E3-ubiquitin ligase family in innate antiviral immunity.

Rajsbaum, Ricardo; García-Sastre, Adolfo; Versteeg, Gijs A.

J Mol Biol ; 426(6): 1265-84, 2014 Mar 20.

Article in English | MEDLINE | ID: mdl-24333484

17.

InTRIMsic immunity: Positive and negative regulation of immune signaling by tripartite motif proteins.

Versteeg, Gijs A; Benke, Stefan; García-Sastre, Adolfo; Rajsbaum, Ricardo.

Cytokine Growth Factor Rev ; 25(5): 563-76, 2014 Oct.

Article in English | MEDLINE | ID: mdl-25172371

18.

Negative regulation of NF-κB activity by brain-specific TRIpartite Motif protein 9.

Shi, Mude; Cho, Hyelim; Inn, Kyung-Soo; Yang, Aerin; Zhao, Zhen; Liang, Qiming; Versteeg, Gijs A; Amini-Bavil-Olyaee, Samad; Wong, Lai-Yee; Zlokovic, Berislav V; Park, Hee-Sung; García-Sastre, Adolfo; Jung, Jae U.

Nat Commun ; 5: 4820, 2014 Sep 05.

Article in English | MEDLINE | ID: mdl-25190485

19.

Regulation of the innate immune system by ubiquitin and ubiquitin-like modifiers.

Oudshoorn, Diede; Versteeg, Gijs A; Kikkert, Marjolein.

Cytokine Growth Factor Rev ; 23(6): 273-82, 2012 Dec.

Article in English | MEDLINE | ID: mdl-22964110

20.

HERC6 is the main E3 ligase for global ISG15 conjugation in mouse cells.

Oudshoorn, Diede; van Boheemen, Sander; Sánchez-Aparicio, Maria Teresa; Rajsbaum, Ricardo; García-Sastre, Adolfo; Versteeg, Gijs A.

PLoS One ; 7(1): e29870, 2012.

Article in English | MEDLINE | ID: mdl-22272257

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