Search details
1.
Identification of a Notch transcriptomic signature for breast cancer.
Breast Cancer Res
; 26(1): 4, 2024 01 03.
Article
in English
| MEDLINE | ID: mdl-38172915
2.
A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease.
Nat Chem Biol
; 11(12): 973-980, 2015 Dec.
Article
in English
| MEDLINE | ID: mdl-26502155
3.
Discovery of potent and selective CDK8 inhibitors from an HSP90 pharmacophore.
Bioorg Med Chem Lett
; 26(5): 1443-51, 2016 Mar 01.
Article
in English
| MEDLINE | ID: mdl-26852363
4.
Novel Methionine Aminopeptidase 2 Inhibitor M8891 Synergizes with VEGF Receptor Inhibitors to Inhibit Tumor Growth of Renal Cell Carcinoma Models.
Mol Cancer Ther
; 23(2): 159-173, 2024 Feb 01.
Article
in English
| MEDLINE | ID: mdl-37940144
5.
Comparative analysis of YAP/TEAD inhibitors in 2D and 3D cultures of primary human hepatocytes reveals a novel non-canonical mechanism of CYP induction.
Biochem Pharmacol
; 215: 115755, 2023 09.
Article
in English
| MEDLINE | ID: mdl-37607620
6.
Optimization of TEAD P-Site Binding Fragment Hit into In Vivo Active Lead MSC-4106.
J Med Chem
; 65(13): 9206-9229, 2022 07 14.
Article
in English
| MEDLINE | ID: mdl-35763499
7.
Endosomes generate localized Rho-ROCK-MLC2-based contractile signals via Endo180 to promote adhesion disassembly.
J Cell Biol
; 175(2): 337-47, 2006 Oct 23.
Article
in English
| MEDLINE | ID: mdl-17043135
8.
3D imaging of colorectal cancer organoids identifies responses to Tankyrase inhibitors.
PLoS One
; 15(8): e0235319, 2020.
Article
in English
| MEDLINE | ID: mdl-32810173
9.
GPI-anchored uPAR requires Endo180 for rapid directional sensing during chemotaxis.
J Cell Biol
; 162(5): 789-94, 2003 Sep 01.
Article
in English
| MEDLINE | ID: mdl-12952933
10.
A novel tankyrase inhibitor, MSC2504877, enhances the effects of clinical CDK4/6 inhibitors.
Sci Rep
; 9(1): 201, 2019 01 17.
Article
in English
| MEDLINE | ID: mdl-30655555
11.
Endosialin is expressed on stromal fibroblasts and CNS pericytes in mouse embryos and is downregulated during development.
Gene Expr Patterns
; 7(3): 363-9, 2007 Jan.
Article
in English
| MEDLINE | ID: mdl-16965941
12.
Identification and characterization of the endocytic transmembrane glycoprotein Endo180 as a novel collagen receptor.
Mol Biol Cell
; 14(9): 3592-604, 2003 Sep.
Article
in English
| MEDLINE | ID: mdl-12972549
13.
Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors.
Nat Commun
; 8: 14262, 2017 02 10.
Article
in English
| MEDLINE | ID: mdl-28186126
14.
Vacuolin, a flotillin/reggie-related protein from Dictyostelium oligomerizes for endosome association.
Eur J Cell Biol
; 85(9-10): 991-1000, 2006 Sep.
Article
in English
| MEDLINE | ID: mdl-16750281
15.
Structure-Based Optimization of Potent, Selective, and Orally Bioavailable CDK8 Inhibitors Discovered by High-Throughput Screening.
J Med Chem
; 59(20): 9337-9349, 2016 Oct 27.
Article
in English
| MEDLINE | ID: mdl-27490956
16.
2,8-Disubstituted-1,6-Naphthyridines and 4,6-Disubstituted-Isoquinolines with Potent, Selective Affinity for CDK8/19.
ACS Med Chem Lett
; 7(6): 573-8, 2016 Jun 09.
Article
in English
| MEDLINE | ID: mdl-27326329
17.
Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Modulators of the Mediator Complex-Associated Kinases CDK8 and CDK19.
J Med Chem
; 59(3): 1078-101, 2016 Feb 11.
Article
in English
| MEDLINE | ID: mdl-26796641
18.
Assessing the mechanism and therapeutic potential of modulators of the human Mediator complex-associated protein kinases.
Elife
; 52016 12 09.
Article
in English
| MEDLINE | ID: mdl-27935476
19.
Endosialin (TEM1, CD248) is a marker of stromal fibroblasts and is not selectively expressed on tumour endothelium.
FEBS Lett
; 579(12): 2569-75, 2005 May 09.
Article
in English
| MEDLINE | ID: mdl-15862292
20.
Discovery of potent, orally bioavailable, small-molecule inhibitors of WNT signaling from a cell-based pathway screen.
J Med Chem
; 58(4): 1717-35, 2015 Feb 26.
Article
in English
| MEDLINE | ID: mdl-25680029