Detalles de la búsqueda
1.
Clinical activity of CC-90011, an oral, potent, and reversible LSD1 inhibitor, in advanced malignancies.
Cancer
; 128(17): 3185-3195, 2022 09 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-35737639
2.
Cooperative antiproliferative signaling by aspirin and indole-3-carbinol targets microphthalmia-associated transcription factor gene expression and promoter activity in human melanoma cells.
Cell Biol Toxicol
; 32(2): 103-19, 2016 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-27055402
3.
2-Amino-7-substituted benzoxazole analogs as potent RSK2 inhibitors.
Bioorg Med Chem Lett
; 24(6): 1592-6, 2014 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-24534486
4.
Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers.
Cancer Discov
; : OF1-OF24, 2024 Apr 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-38593348
5.
Trotabresib, an oral potent bromodomain and extraterminal inhibitor, in patients with high-grade gliomas: A phase I, "window-of-opportunity" study.
Neuro Oncol
; 25(6): 1113-1122, 2023 06 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-36455228
6.
BET inhibitor trotabresib in heavily pretreated patients with solid tumors and diffuse large B-cell lymphomas.
Nat Commun
; 14(1): 1359, 2023 03 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-36914652
7.
Target protein interactions of indole-3-carbinol and the highly potent derivative 1-benzyl-I3C with the C-terminal domain of human elastase uncouples cell cycle arrest from apoptotic signaling.
Mol Carcinog
; 51(11): 881-94, 2012 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-22012859
8.
Trotabresib (CC-90010) in combination with adjuvant temozolomide or concomitant temozolomide plus radiotherapy in patients with newly diagnosed glioblastoma.
Neurooncol Adv
; 4(1): vdac146, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-36382109
9.
The dietary phytochemical indole-3-carbinol is a natural elastase enzymatic inhibitor that disrupts cyclin E protein processing.
Proc Natl Acad Sci U S A
; 105(50): 19750-5, 2008 Dec 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-19064917
10.
Phase I Study of Lysine-Specific Demethylase 1 Inhibitor, CC-90011, in Patients with Advanced Solid Tumors and Relapsed/Refractory Non-Hodgkin Lymphoma.
Clin Cancer Res
; 27(2): 438-446, 2021 01 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-33046517
11.
Indole-3-carbinol inhibits MDA-MB-231 breast cancer cell motility and induces stress fibers and focal adhesion formation by activation of Rho kinase activity.
Int J Cancer
; 124(10): 2294-302, 2009 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19173291
12.
DEVD-NucView488: a novel class of enzyme substrates for real-time detection of caspase-3 activity in live cells.
FASEB J
; 22(7): 2243-52, 2008 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-18263700
13.
Efficacy of a Covalent ERK1/2 Inhibitor, CC-90003, in KRAS-Mutant Cancer Models Reveals Novel Mechanisms of Response and Resistance.
Mol Cancer Res
; 17(2): 642-654, 2019 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-30275173
14.
Indole-3-carbinol (I3C) analogues are potent small molecule inhibitors of NEDD4-1 ubiquitin ligase activity that disrupt proliferation of human melanoma cells.
Biochem Pharmacol
; 127: 13-27, 2017 03 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27979631
15.
Actin reorganization is abnormal and cellular ATP is decreased in Hailey-Hailey keratinocytes.
J Invest Dermatol
; 121(4): 681-7, 2003 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-14632182
16.
Human keratinocyte ATP2C1 localizes to the Golgi and controls Golgi Ca2+ stores.
J Invest Dermatol
; 121(4): 688-94, 2003 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-14632183
17.
Neonatal development of the stratum corneum pH gradient: localization and mechanisms leading to emergence of optimal barrier function.
J Invest Dermatol
; 120(6): 998-1006, 2003 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-12787127
18.
The antiproliferative response of indole-3-carbinol in human melanoma cells is triggered by an interaction with NEDD4-1 and disruption of wild-type PTEN degradation.
Mol Cancer Res
; 12(11): 1621-1634, 2014 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-25009292
19.
Novel potent and selective inhibitors of p90 ribosomal S6 kinase reveal the heterogeneity of RSK function in MAPK-driven cancers.
Mol Cancer Res
; 12(5): 803-12, 2014 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-24554780
20.
Direct inhibition of elastase activity by indole-3-carbinol triggers a CD40-TRAF regulatory cascade that disrupts NF-kappaB transcriptional activity in human breast cancer cells.
Cancer Res
; 70(12): 4961-71, 2010 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20530686