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1.
Design and synthesis of 4th generation EGFR inhibitors against human triple (Del19/T790M/C797S) mutation.
Eur J Med Chem
; 261: 115840, 2023 Dec 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-37783102
2.
Targeting HIF-1α/NOTCH1 pathway eliminates CD44+ cancer stem-like cell phenotypes, malignancy, and resistance to therapy in head and neck squamous cell carcinoma.
Oncogene
; 41(9): 1352-1363, 2022 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-35013621
3.
Triterpenoid pristimerin synergizes with taxol to induce cervical cancer cell death through reactive oxygen species-mediated mitochondrial dysfunction.
Anticancer Drugs
; 22(8): 763-73, 2011 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-21642840
4.
Target modulation and pharmacokinetics/pharmacodynamics translation of the BTK inhibitor poseltinib for model-informed phase II dose selection.
Sci Rep
; 11(1): 18671, 2021 09 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-34548595
5.
Activation of p38 mitogen-activated protein kinase is required for death receptor-independent caspase-8 activation and cell death in response to sphingosine.
Mol Cancer Res
; 7(3): 361-70, 2009 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-19276187
6.
Reactive oxygen species-dependent activation of Bax and poly(ADP-ribose) polymerase-1 is required for mitochondrial cell death induced by triterpenoid pristimerin in human cervical cancer cells.
Mol Pharmacol
; 76(4): 734-44, 2009 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-19574249
7.
The Rac1/MKK7/JNK pathway signals upregulation of Atg5 and subsequent autophagic cell death in response to oncogenic Ras.
Carcinogenesis
; 30(11): 1880-8, 2009 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-19783847
8.
c-Src-p38 mitogen-activated protein kinase signaling is required for Akt activation in response to ionizing radiation.
Mol Cancer Res
; 6(12): 1872-80, 2008 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-19074832
9.
Activation of Lck is critically required for sphingosine-induced conformational activation of Bak and mitochondrial cell death.
Biochem Biophys Res Commun
; 370(2): 353-8, 2008 May 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-18371298
10.
HM71224, a selective Bruton's tyrosine kinase inhibitor, attenuates the development of murine lupus.
Arthritis Res Ther
; 19(1): 211, 2017 09 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-28950886
11.
HM71224, a novel Bruton's tyrosine kinase inhibitor, suppresses B cell and monocyte activation and ameliorates arthritis in a mouse model: a potential drug for rheumatoid arthritis.
Arthritis Res Ther
; 18: 91, 2016 Apr 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-27090981
12.
Synthesis and biological evaluation of pyrimidine-based dual inhibitors of human epidermal growth factor receptor 1 (HER-1) and HER-2 tyrosine kinases.
J Med Chem
; 55(6): 2846-57, 2012 Mar 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-22372864
13.
Oncogenic Ras signals through activation of both phosphoinositide 3-kinase and Rac1 to induce c-Jun NH2-terminal kinase-mediated, caspase-independent cell death.
Mol Cancer Res
; 7(9): 1534-42, 2009 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-19723872
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