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1.
An open label trial of nemiralisib, an inhaled PI3 kinase delta inhibitor for the treatment of Activated PI3 kinase Delta Syndrome.
Pulm Pharmacol Ther
; 79: 102201, 2023 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-36841351
2.
Evaluation of Dynamic Contrast-Enhanced MRI Measures of Lung Congestion and Endothelial Permeability in Heart Failure: A Prospective Method Validation Study.
J Magn Reson Imaging
; 56(2): 450-461, 2022 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-35343008
3.
Assessment of the safety, pharmacokinetics and pharmacodynamics of GSK3335065, an inhibitor of kynurenine monooxygenase, in a randomised placebo-controlled first-in-human study in healthy volunteers.
Br J Clin Pharmacol
; 88(2): 865-870, 2022 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-34327739
4.
A randomized study of the safety and pharmacokinetics of GSK3358699, a mononuclear myeloid-targeted bromodomain and extra-terminal domain inhibitor.
Br J Clin Pharmacol
; 88(5): 2140-2155, 2022 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-34773923
5.
Translation of Inhaled Drug Optimization Strategies into Clinical Pharmacokinetics and Pharmacodynamics Using GSK2292767A, a Novel Inhaled Phosphoinositide 3-Kinase δ Inhibitor.
J Pharmacol Exp Ther
; 369(3): 443-453, 2019 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-30940692
6.
Anti-IL-7 receptor α monoclonal antibody (GSK2618960) in healthy subjects - a randomized, double-blind, placebo-controlled study.
Br J Clin Pharmacol
; 85(2): 304-315, 2019 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-30161291
7.
In vivo affinity and target engagement in skin and blood in a first-time-in-human study of an anti-oncostatin M monoclonal antibody.
Br J Clin Pharmacol
; 84(10): 2280-2291, 2018 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-29900565
8.
CCL20 neutralization by a monoclonal antibody in healthy subjects selectively inhibits recruitment of CCR6+ cells in an experimental suction blister.
Br J Clin Pharmacol
; 83(9): 1976-1990, 2017 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-28295451
9.
Characterisation of the clinical and activated T cell response to repeat delayed-type hypersensitivity skin challenges in human subjects, with KLH and PPD, as a potential model to test T cell-targeted therapies.
Inflamm Res
; 65(5): 389-404, 2016 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-26969026
10.
Tafenoquine co-administered with dihydroartemisinin-piperaquine for the radical cure of Plasmodium vivax malaria (INSPECTOR): a randomised, placebo-controlled, efficacy and safety study.
Lancet Infect Dis
; 23(10): 1153-1163, 2023 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-37236221
11.
Identification, preclinical profile, and clinical proof of concept of an orally bioavailable pro-drug of miridesap.
Br J Pharmacol
; 177(8): 1853-1864, 2020 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-31877231
12.
Phase I evaluation of the safety, tolerability, and pharmacokinetics of GSK3640254, a next-generation HIV-1 maturation inhibitor.
Pharmacol Res Perspect
; 8(6): e00671, 2020 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-33200887
13.
Clinical Pharmacokinetics, Safety, and Tolerability of a Novel, First-in-Class TRPV4 Ion Channel Inhibitor, GSK2798745, in Healthy and Heart Failure Subjects.
Am J Cardiovasc Drugs
; 19(3): 335-342, 2019 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-30637626
14.
Quantifying disease activity in rheumatoid arthritis with the TSPO PET ligand 18F-GE-180 and comparison with 18F-FDG and DCE-MRI.
EJNMMI Res
; 9(1): 113, 2019 Dec 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-31858293
15.
Opioid Antagonists and the A118G Polymorphism in the µ-Opioid Receptor Gene: Effects of GSK1521498 and Naltrexone in Healthy Drinkers Stratified by OPRM1 Genotype.
Neuropsychopharmacology
; 43(4): 927, 2018 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-29422496
16.
Safety, Tolerability and Pharmacokinetics of Single Doses of Oxytocin Administered via an Inhaled Route in Healthy Females: Randomized, Single-blind, Phase 1 Study.
EBioMedicine
; 22: 249-255, 2017 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-28781129
17.
Opioid Antagonists and the A118G Polymorphism in the µ-Opioid Receptor Gene: Effects of GSK1521498 and Naltrexone in Healthy Drinkers Stratified by OPRM1 Genotype.
Neuropsychopharmacology
; 41(11): 2647-57, 2016 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-27109624
18.
The effect of a combination of gabapentin and donepezil in an experimental pain model in healthy volunteers: Results of a randomized controlled trial.
Pain
; 155(12): 2510-2516, 2014 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-25218827
19.
A randomised trial evaluating the effects of the TRPV1 antagonist SB705498 on pruritus induced by histamine, and cowhage challenge in healthy volunteers.
PLoS One
; 9(7): e100610, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-25047038
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