Detalles de la búsqueda
1.
BET inhibition blocks inflammation-induced cardiac dysfunction and SARS-CoV-2 infection.
Cell
; 184(8): 2167-2182.e22, 2021 04 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-33811809
2.
Pharmacologic epigenetic modulators of alkaline phosphatase in chronic kidney disease.
Curr Opin Nephrol Hypertens
; 29(1): 4-15, 2020 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31725015
3.
RVX-297, a BET Bromodomain Inhibitor, Has Therapeutic Effects in Preclinical Models of Acute Inflammation and Autoimmune Disease.
Mol Pharmacol
; 92(6): 694-706, 2017 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-28974538
4.
Apabetalone, a Clinical-Stage, Selective BET Inhibitor, Opposes DUX4 Target Gene Expression in Primary Human FSHD Muscle Cells.
Biomedicines
; 11(10)2023 Sep 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-37893058
5.
Epigenetic BET reader inhibitor apabetalone (RVX-208) counters proinflammatory aortic gene expression in a diet induced obesity mouse model and in human endothelial cells.
Atherosclerosis
; 364: 10-19, 2023 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-36455344
6.
Dual mechanism: Epigenetic inhibitor apabetalone reduces SARS-CoV-2 Delta and Omicron variant spike binding and attenuates SARS-CoV-2 RNA induced inflammation.
Int Immunopharmacol
; 117: 109929, 2023 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-36857935
7.
Apabetalone Downregulates Fibrotic, Inflammatory and Calcific Processes in Renal Mesangial Cells and Patients with Renal Impairment.
Biomedicines
; 11(6)2023 Jun 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-37371758
8.
The BET inhibitor apabetalone decreases neuroendothelial proinflammatory activation in vitro and in a mouse model of systemic inflammation.
Transl Neurosci
; 14(1): 20220332, 2023 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-38222824
9.
Breaking boundaries: Pan BETi disrupt 3D chromatin structure, BD2-selective BETi are strictly epigenetic transcriptional regulators.
Biomed Pharmacother
; 152: 113230, 2022 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-35687908
10.
Bromodomain and Extraterminal Protein Inhibitor, Apabetalone (RVX-208), Reduces ACE2 Expression and Attenuates SARS-Cov-2 Infection In Vitro.
Biomedicines
; 9(4)2021 Apr 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-33919584
11.
Adipocyte LDL receptor-related protein-1 expression modulates postprandial lipid transport and glucose homeostasis in mice.
J Clin Invest
; 117(11): 3271-82, 2007 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-17948131
12.
Epigenetic Modulation by Apabetalone Counters Cytokine-Driven Acute Phase Response In Vitro, in Mice and in Patients with Cardiovascular Disease.
Cardiovasc Ther
; 2020: 9397109, 2020.
Artículo
en Inglés
| MEDLINE | ID: mdl-32821285
13.
Apabetalone downregulates factors and pathways associated with vascular calcification.
Atherosclerosis
; 280: 75-84, 2019 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30476723
14.
Apabetalone (RVX-208) reduces vascular inflammation in vitro and in CVD patients by a BET-dependent epigenetic mechanism.
Clin Epigenetics
; 11(1): 102, 2019 07 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-31300040
15.
Triacylglycerol hydrolase is localized to the endoplasmic reticulum by an unusual retrieval sequence where it participates in VLDL assembly without utilizing VLDL lipids as substrates.
Mol Biol Cell
; 16(2): 984-96, 2005 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-15601899
16.
Benefit of Apabetalone on Plasma Proteins in Renal Disease.
Kidney Int Rep
; 3(3): 711-721, 2018 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-29854980
17.
Downregulation of the Complement Cascade In Vitro, in Mice and in Patients with Cardiovascular Disease by the BET Protein Inhibitor Apabetalone (RVX-208).
J Cardiovasc Transl Res
; 10(4): 337-347, 2017 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-28567671
18.
Insulin, glucagon and fatty acid treatment of hepatocytes does not result in phosphorylation or changes in activity of triacylglycerol hydrolase.
Biochim Biophys Acta
; 1736(3): 189-99, 2005 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-16168708
19.
RVX-208, a BET-inhibitor for treating atherosclerotic cardiovascular disease, raises ApoA-I/HDL and represses pathways that contribute to cardiovascular disease.
Atherosclerosis
; 247: 48-57, 2016 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-26868508
20.
Data on gene and protein expression changes induced by apabetalone (RVX-208) in ex vivo treated human whole blood and primary hepatocytes.
Data Brief
; 8: 1280-8, 2016 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-27570805