Búsqueda | Biblioteca Virtual en Salud

1.

Cathepsin S Contributes to Lung Inflammation in Acute Respiratory Distress Syndrome.

McKelvey, Michael C; Abladey, Anthony A; Small, Donna M; Doherty, Declan F; Williams, Richard; Scott, Aaron; Spek, C Arnold; Borensztajn, Keren S; Holsinger, Leslie; Booth, Robert; O'Kane, Cecilia M; McAuley, Daniel F; Taggart, Clifford C; Weldon, Sinéad.

Am J Respir Crit Care Med ; 205(7): 769-782, 2022 04 01.

Artículo en Inglés | MEDLINE | ID: mdl-35073247

2.

Therapeutic Inhibition of Cathepsin S Reduces Inflammation and Mucus Plugging in Adult ßENaC-Tg Mice.

Brown, Ryan; Small, Donna M; Doherty, Declan F; Holsinger, Leslie; Booth, Robert; Williams, Richard; Ingram, Rebecca J; Elborn, J Stuart; Mall, Marcus A; Taggart, Clifford C; Weldon, Sinéad.

Mediators Inflamm ; 2021: 6682657, 2021.

Artículo en Inglés | MEDLINE | ID: mdl-33828414

3.

Targeting of cathepsin S reduces cystic fibrosis-like lung disease.

Small, Donna M; Brown, Ryan R; Doherty, Declan F; Abladey, Anthony; Zhou-Suckow, Zhe; Delaney, Rebecca J; Kerrigan, Lauren; Dougan, Caoifa M; Borensztajn, Keren S; Holsinger, Leslie; Booth, Robert; Scott, Christopher J; López-Campos, Guillermo; Elborn, J Stuart; Mall, Marcus A; Weldon, Sinéad; Taggart, Clifford C.

Eur Respir J ; 53(3)2019 03.

Artículo en Inglés | MEDLINE | ID: mdl-30655278

4.

Extracellular domain dependence of PTPalpha transforming activity.

Tremper-Wells, Barbara; Resnick, Ross J; Zheng, Xinmin; Holsinger, Leslie J; Shalloway, David.

Genes Cells ; 15(7): 711-724, 2010 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-20545765

5.

Alzheimer's Disease-Like Neurodegeneration in Porphyromonas gingivalis Infected Neurons with Persistent Expression of Active Gingipains.

Haditsch, Ursula; Roth, Theresa; Rodriguez, Leo; Hancock, Sandy; Cecere, Thomas; Nguyen, Mai; Arastu-Kapur, Shirin; Broce, Sean; Raha, Debasish; Lynch, Casey C; Holsinger, Leslie J; Dominy, Stephen S; Ermini, Florian.

J Alzheimers Dis ; 75(4): 1361-1376, 2020.

Artículo en Inglés | MEDLINE | ID: mdl-32390638

6.

Treatment of Porphyromonas gulae infection and downstream pathology in the aged dog by lysine-gingipain inhibitor COR388.

Arastu-Kapur, Shirin; Nguyen, Mai; Raha, Debasish; Ermini, Florian; Haditsch, Ursula; Araujo, Joseph; De Lannoy, Ines A M; Ryder, Mark I; Dominy, Stephen S; Lynch, Casey; Holsinger, Leslie J.

Pharmacol Res Perspect ; 8(1): e00562, 2020 02.

Artículo en Inglés | MEDLINE | ID: mdl-31999052

7.

Porphyromonas gingivalis in Alzheimer's disease brains: Evidence for disease causation and treatment with small-molecule inhibitors.

Dominy, Stephen S; Lynch, Casey; Ermini, Florian; Benedyk, Malgorzata; Marczyk, Agata; Konradi, Andrei; Nguyen, Mai; Haditsch, Ursula; Raha, Debasish; Griffin, Christina; Holsinger, Leslie J; Arastu-Kapur, Shirin; Kaba, Samer; Lee, Alexander; Ryder, Mark I; Potempa, Barbara; Mydel, Piotr; Hellvard, Annelie; Adamowicz, Karina; Hasturk, Hatice; Walker, Glenn D; Reynolds, Eric C; Faull, Richard L M; Curtis, Maurice A; Dragunow, Mike; Potempa, Jan.

Sci Adv ; 5(1): eaau3333, 2019 01.

Artículo en Inglés | MEDLINE | ID: mdl-30746447

8.

The transmembrane receptor protein tyrosine phosphatase DEP1 interacts with p120(ctn).

Holsinger, Leslie J; Ward, Kevin; Duffield, Bill; Zachwieja, Joseph; Jallal, Bahija.

Oncogene ; 21(46): 7067-76, 2002 Oct 10.

Artículo en Inglés | MEDLINE | ID: mdl-12370829

9.

Analysis of tumour- and stroma-supplied proteolytic networks reveals a brain-metastasis-promoting role for cathepsin S.

Sevenich, Lisa; Bowman, Robert L; Mason, Steven D; Quail, Daniela F; Rapaport, Franck; Elie, Benelita T; Brogi, Edi; Brastianos, Priscilla K; Hahn, William C; Holsinger, Leslie J; Massagué, Joan; Leslie, Christina S; Joyce, Johanna A.

Nat Cell Biol ; 16(9): 876-88, 2014 Sep.

Artículo en Inglés | MEDLINE | ID: mdl-25086747

10.

Identification and pre-clinical testing of a reversible cathepsin protease inhibitor reveals anti-tumor efficacy in a pancreatic cancer model.

Elie, Benelita Tina; Gocheva, Vasilena; Shree, Tanaya; Dalrymple, Stacie A; Holsinger, Leslie J; Joyce, Johanna A.

Biochimie ; 92(11): 1618-24, 2010 Nov.

Artículo en Inglés | MEDLINE | ID: mdl-20447439

11.

The minimal essential core of a cysteine-based protein-tyrosine phosphatase revealed by a novel 16-kDa VH1-like phosphatase, VHZ.

Alonso, Andres; Burkhalter, Stephen; Sasin, Joanna; Tautz, Lutz; Bogetz, Jori; Huynh, Huong; Bremer, Meire C D; Holsinger, Leslie J; Godzik, Adam; Mustelin, Tomas.

J Biol Chem ; 279(34): 35768-74, 2004 Aug 20.

Artículo en Inglés | MEDLINE | ID: mdl-15201283

12.

The oxidative mechanism of action of ortho-quinone inhibitors of protein-tyrosine phosphatase alpha is mediated by hydrogen peroxide.

Bova, Michael P; Mattson, Matthew N; Vasile, Stefan; Tam, Danny; Holsinger, Leslie; Bremer, Meire; Hui, Terence; McMahon, Gerald; Rice, Audie; Fukuto, Jon M.

Arch Biochem Biophys ; 429(1): 30-41, 2004 Sep 01.

Artículo en Inglés | MEDLINE | ID: mdl-15288807

13.

VHY, a novel myristoylated testis-restricted dual specificity protein phosphatase related to VHX.

Alonso, Andres; Narisawa, Sonoko; Bogetz, Jori; Tautz, Lutz; Hadzic, Radinka; Huynh, Huong; Williams, Scott; Gjörloff-Wingren, Anette; Bremer, Meire C D; Holsinger, Leslie J; Millan, José L; Mustelin, Tomas.

J Biol Chem ; 279(31): 32586-91, 2004 Jul 30.

Artículo en Inglés | MEDLINE | ID: mdl-15138252

14.

A battle with my skin.

Holsinger, Leslie.

J Am Acad Dermatol ; 51(1 Suppl): S41-2, 2004 Jul.

Artículo en Inglés | MEDLINE | ID: mdl-15243506

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